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Infectious adaptation: potential host range of a defensive endosymbiont in Drosophila.
Evolution 2013; 67(4):934-45E

Abstract

Maternally transmitted symbionts persist over macroevolutionary timescales by undergoing occasional lateral transfer to new host species. To invade a new species, a symbiont must survive and reproduce in the new host, undergo maternal transmission, and confer a selective benefit sufficient to overcome losses due to imperfect maternal transmission. Drosophila neotestacea is naturally infected with a strain of Spiroplasma that restores fertility to nematode-parasitized females, which are otherwise sterilized by parasitism. We experimentally transferred Spiroplasma from D. neotestacea to four other species of mycophagous Drosophila that vary in their ability to resist and/or tolerate nematode parasitism. In all four species, Spiroplasma achieved within-host densities and experienced rates of maternal transmission similar to that in D. neotestacea. Spiroplasma restored fertility to nematode-parasitized females in one of these novel host species. Based on estimates of maternal transmission fidelity and the expected benefit of Spiroplasma infection in the wild, we conclude that Spiroplasma has the potential to spread and become abundant within Drosophila putrida, which is broadly sympatric with D. neotestacea and in which females are rendered completely sterile by nematode parasitism. Thus, a major adaptation within D. putrida could arise via lateral transmission of a heritable symbiont from D. neotestacea.

Authors+Show Affiliations

Department of Biology, University of Rochester, Rochester, New York, 14627, USA. thaselko@z.rochester.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23550746

Citation

Haselkorn, Tamara S., et al. "Infectious Adaptation: Potential Host Range of a Defensive Endosymbiont in Drosophila." Evolution; International Journal of Organic Evolution, vol. 67, no. 4, 2013, pp. 934-45.
Haselkorn TS, Cockburn SN, Hamilton PT, et al. Infectious adaptation: potential host range of a defensive endosymbiont in Drosophila. Evolution. 2013;67(4):934-45.
Haselkorn, T. S., Cockburn, S. N., Hamilton, P. T., Perlman, S. J., & Jaenike, J. (2013). Infectious adaptation: potential host range of a defensive endosymbiont in Drosophila. Evolution; International Journal of Organic Evolution, 67(4), pp. 934-45. doi:10.1111/evo.12020.
Haselkorn TS, et al. Infectious Adaptation: Potential Host Range of a Defensive Endosymbiont in Drosophila. Evolution. 2013;67(4):934-45. PubMed PMID: 23550746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infectious adaptation: potential host range of a defensive endosymbiont in Drosophila. AU - Haselkorn,Tamara S, AU - Cockburn,Sarah N, AU - Hamilton,Phineas T, AU - Perlman,Steve J, AU - Jaenike,John, Y1 - 2012/12/24/ PY - 2013/4/5/entrez PY - 2013/4/5/pubmed PY - 2013/9/24/medline SP - 934 EP - 45 JF - Evolution; international journal of organic evolution JO - Evolution VL - 67 IS - 4 N2 - Maternally transmitted symbionts persist over macroevolutionary timescales by undergoing occasional lateral transfer to new host species. To invade a new species, a symbiont must survive and reproduce in the new host, undergo maternal transmission, and confer a selective benefit sufficient to overcome losses due to imperfect maternal transmission. Drosophila neotestacea is naturally infected with a strain of Spiroplasma that restores fertility to nematode-parasitized females, which are otherwise sterilized by parasitism. We experimentally transferred Spiroplasma from D. neotestacea to four other species of mycophagous Drosophila that vary in their ability to resist and/or tolerate nematode parasitism. In all four species, Spiroplasma achieved within-host densities and experienced rates of maternal transmission similar to that in D. neotestacea. Spiroplasma restored fertility to nematode-parasitized females in one of these novel host species. Based on estimates of maternal transmission fidelity and the expected benefit of Spiroplasma infection in the wild, we conclude that Spiroplasma has the potential to spread and become abundant within Drosophila putrida, which is broadly sympatric with D. neotestacea and in which females are rendered completely sterile by nematode parasitism. Thus, a major adaptation within D. putrida could arise via lateral transmission of a heritable symbiont from D. neotestacea. SN - 1558-5646 UR - https://www.unboundmedicine.com/medline/citation/23550746/Infectious_adaptation:_potential_host_range_of_a_defensive_endosymbiont_in_Drosophila_ L2 - https://doi.org/10.1111/evo.12020 DB - PRIME DP - Unbound Medicine ER -