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Ellagic acid and derivatives from Cochlospermum angolensis Welw. Extracts: HPLC-DAD-ESI/MS(n) profiling, quantification and in vitro anti-depressant, anti-cholinesterase and anti-oxidant activities.
Phytochem Anal. 2013 Nov-Dec; 24(6):534-40.PA

Abstract

INTRODUCTION

Cochlospermum angolensis Welw. bark is a medicinal plant consumed for the treatment of hepatic diseases and for the prophylaxis of malaria. Nevertheless, there are few studies concerning its chemical composition and biological potential.

OBJECTIVE

Since phenolic compounds are described as powerful anti-oxidants and neuroprotective agents, the purpose of this study was to characterise the phenolic profile of this species and to extend the knowledge on its medicinal properties, namely its potential against oxidative stress, Alzheimer's disease and depression.

METHODS

The phenolic composition of aqueous and hydromethanolic extracts was characterised by HPLC-DAD-ESI/MS(n) . Anti-radical potential was tested against 2,2-diphenyl-1-picrylhdrazyl, superoxide anion and nitric oxide radicals, and neuroprotective effect was assessed against acetylcholinesterase, butyrylcholinesterase and monoamine oxidase A.

RESULTS

Eight compounds were characterised for the first time. Hydromethanolic extract was richer in methyl ellagic acid and its derivatives, while aqueous extract had higher amounts of ellagic acid and its derivatives. Methyl ellagic acid pentoside isomer and ellagic acid were the major compounds in the two extracts, respectively. Both extracts and ellagic acid revealed radical scavenging capacity stronger than that of ascorbic acid, but a weak effect on cholinesterases was observed. Their anti-depressant activity was also very strong.

CONCLUSION

The results provided evidence of the value of C. angolensis as a source of health-promoting anti-oxidants and anti-depressant compounds, with potential to be used as a raw product for food and pharmaceutical industries.

Authors+Show Affiliations

Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), Campus University Espinardo, P.O. Box 164, 30100, Murcia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23553958

Citation

Ferreres, Federico, et al. "Ellagic Acid and Derivatives From Cochlospermum Angolensis Welw. Extracts: HPLC-DAD-ESI/MS(n) Profiling, Quantification and in Vitro Anti-depressant, Anti-cholinesterase and Anti-oxidant Activities." Phytochemical Analysis : PCA, vol. 24, no. 6, 2013, pp. 534-40.
Ferreres F, Grosso C, Gil-Izquierdo A, et al. Ellagic acid and derivatives from Cochlospermum angolensis Welw. Extracts: HPLC-DAD-ESI/MS(n) profiling, quantification and in vitro anti-depressant, anti-cholinesterase and anti-oxidant activities. Phytochem Anal. 2013;24(6):534-40.
Ferreres, F., Grosso, C., Gil-Izquierdo, A., Valentão, P., & Andrade, P. B. (2013). Ellagic acid and derivatives from Cochlospermum angolensis Welw. Extracts: HPLC-DAD-ESI/MS(n) profiling, quantification and in vitro anti-depressant, anti-cholinesterase and anti-oxidant activities. Phytochemical Analysis : PCA, 24(6), 534-40. https://doi.org/10.1002/pca.2429
Ferreres F, et al. Ellagic Acid and Derivatives From Cochlospermum Angolensis Welw. Extracts: HPLC-DAD-ESI/MS(n) Profiling, Quantification and in Vitro Anti-depressant, Anti-cholinesterase and Anti-oxidant Activities. Phytochem Anal. 2013 Nov-Dec;24(6):534-40. PubMed PMID: 23553958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ellagic acid and derivatives from Cochlospermum angolensis Welw. Extracts: HPLC-DAD-ESI/MS(n) profiling, quantification and in vitro anti-depressant, anti-cholinesterase and anti-oxidant activities. AU - Ferreres,Federico, AU - Grosso,Clara, AU - Gil-Izquierdo,Angel, AU - Valentão,Patrícia, AU - Andrade,Paula B, Y1 - 2013/04/01/ PY - 2012/12/17/received PY - 2013/01/21/revised PY - 2013/01/28/accepted PY - 2013/4/5/entrez PY - 2013/4/5/pubmed PY - 2014/5/30/medline KW - Cochlospermum angolensis welw KW - HPLC-DAD-ESI/MSn KW - anti-depressant activity KW - anti-radical activity KW - ellagic acid derivatives SP - 534 EP - 40 JF - Phytochemical analysis : PCA JO - Phytochem Anal VL - 24 IS - 6 N2 - INTRODUCTION: Cochlospermum angolensis Welw. bark is a medicinal plant consumed for the treatment of hepatic diseases and for the prophylaxis of malaria. Nevertheless, there are few studies concerning its chemical composition and biological potential. OBJECTIVE: Since phenolic compounds are described as powerful anti-oxidants and neuroprotective agents, the purpose of this study was to characterise the phenolic profile of this species and to extend the knowledge on its medicinal properties, namely its potential against oxidative stress, Alzheimer's disease and depression. METHODS: The phenolic composition of aqueous and hydromethanolic extracts was characterised by HPLC-DAD-ESI/MS(n) . Anti-radical potential was tested against 2,2-diphenyl-1-picrylhdrazyl, superoxide anion and nitric oxide radicals, and neuroprotective effect was assessed against acetylcholinesterase, butyrylcholinesterase and monoamine oxidase A. RESULTS: Eight compounds were characterised for the first time. Hydromethanolic extract was richer in methyl ellagic acid and its derivatives, while aqueous extract had higher amounts of ellagic acid and its derivatives. Methyl ellagic acid pentoside isomer and ellagic acid were the major compounds in the two extracts, respectively. Both extracts and ellagic acid revealed radical scavenging capacity stronger than that of ascorbic acid, but a weak effect on cholinesterases was observed. Their anti-depressant activity was also very strong. CONCLUSION: The results provided evidence of the value of C. angolensis as a source of health-promoting anti-oxidants and anti-depressant compounds, with potential to be used as a raw product for food and pharmaceutical industries. SN - 1099-1565 UR - https://www.unboundmedicine.com/medline/citation/23553958/Ellagic_acid_and_derivatives_from_Cochlospermum_angolensis_Welw__Extracts:_HPLC_DAD_ESI/MS_n__profiling_quantification_and_in_vitro_anti_depressant_anti_cholinesterase_and_anti_oxidant_activities_ L2 - https://doi.org/10.1002/pca.2429 DB - PRIME DP - Unbound Medicine ER -