TY - JOUR T1 - Multicenter, double-blind, parallel group study investigating the non-inferiority of efficacy and safety of a 2% miconazole nitrate shampoo in comparison with a 2% ketoconazole shampoo in the treatment of seborrhoeic dermatitis of the scalp. A1 - Buechner,Stanislaw A, Y1 - 2013/05/21/ PY - 2013/4/6/entrez PY - 2013/4/6/pubmed PY - 2014/4/2/medline SP - 226 EP - 31 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 25 IS - 3 N2 - OBJECTIVES: This study investigated the non-inferiority of efficacy and tolerance of 2% miconazole nitrate shampoo in comparison with 2% ketoconazole shampoo in the treatment of scalp seborrheic dermatitis. METHODS: A randomized, double-blind, comparative, parallel group, multicenter study was done. A total of 274 patients (145 miconazole, 129 ketoconazole) were enrolled. Treatment was twice-weekly for 4 weeks. Safety and efficacy assessments were made at baseline and at weeks 2 and 4. Assessments included symptoms of erythema, itching, scaling ['Symptom Scale of Seborrhoeic Dermatitis' (SSSD)], disease severity and global change [Clinical Global Impressions (CGIs) and Patient Global Impressions (PGIs)]. CONCLUSIONS: Miconazole shampoo is at least as effective and safe as ketoconazole shampoo in treating scalp seborrheic dermatitis scalp. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/23557492/Multicenter_double_blind_parallel_group_study_investigating_the_non_inferiority_of_efficacy_and_safety_of_a_2_miconazole_nitrate_shampoo_in_comparison_with_a_2_ketoconazole_shampoo_in_the_treatment_of_seborrhoeic_dermatitis_of_the_scalp_ DB - PRIME DP - Unbound Medicine ER -