Tags

Type your tag names separated by a space and hit enter

Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients.
Cytokine 2013; 62(2):286-9C

Abstract

Interleukin 18 (IL-18) is a cytokine that plays an important role in the Th1 response, by its ability to induce IFN-γ production in T cells and natural killer cells. Functional variants of IL18 gene has been reported as associated with type 1 diabetes (T1D). In the present study were analyzed three promoter single nucleotide polymorphisms (SNPs), at -656 (rs1946519), -607 (rs1946518) and -137 (rs187238) position, in 181 children and adolescents with T1D and 122 healthy individuals, both from metropolitan area of Recife, Northeast of Brazil. T1D patients were stratified according to the presence autoimmune thyroiditis and celiac disease. Allele and genotype frequencies of IL18 SNPs were Hardy-Weinberg equilibrium in patients and controls. The allele -137G and the haplotype -656G/-607C/-137G were more frequent in T1D patients (OR=1.82 and 1.97, respectively) then in healthy controls. However, those SNPs were not associated with the age of T1D onset as well as with the insurgence of AITD and/or CD in concomitant with T1D patients. Our findings suggest an association between IL18 promoter SNPs and susceptibility to T1D in Brazilian patients.

Authors+Show Affiliations

Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, Pernambuco, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23557801

Citation

Tavares, Nathália A C., et al. "Interleukin 18 (IL18) Gene Promoter Polymorphisms Are Associated With Type 1 Diabetes Mellitus in Brazilian Patients." Cytokine, vol. 62, no. 2, 2013, pp. 286-9.
Tavares NA, Santos MM, Moura R, et al. Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients. Cytokine. 2013;62(2):286-9.
Tavares, N. A., Santos, M. M., Moura, R., Araújo, J., Guimarães, R., Crovella, S., & Brandão, L. (2013). Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients. Cytokine, 62(2), pp. 286-9. doi:10.1016/j.cyto.2013.03.004.
Tavares NA, et al. Interleukin 18 (IL18) Gene Promoter Polymorphisms Are Associated With Type 1 Diabetes Mellitus in Brazilian Patients. Cytokine. 2013;62(2):286-9. PubMed PMID: 23557801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients. AU - Tavares,Nathália A C, AU - Santos,Manuella M S, AU - Moura,Ronald, AU - Araújo,Jacqueline, AU - Guimarães,Rafael, AU - Crovella,Sergio, AU - Brandão,Lucas, Y1 - 2013/04/02/ PY - 2012/09/10/received PY - 2013/03/08/revised PY - 2013/03/10/accepted PY - 2013/4/6/entrez PY - 2013/4/6/pubmed PY - 2014/1/30/medline SP - 286 EP - 9 JF - Cytokine JO - Cytokine VL - 62 IS - 2 N2 - Interleukin 18 (IL-18) is a cytokine that plays an important role in the Th1 response, by its ability to induce IFN-γ production in T cells and natural killer cells. Functional variants of IL18 gene has been reported as associated with type 1 diabetes (T1D). In the present study were analyzed three promoter single nucleotide polymorphisms (SNPs), at -656 (rs1946519), -607 (rs1946518) and -137 (rs187238) position, in 181 children and adolescents with T1D and 122 healthy individuals, both from metropolitan area of Recife, Northeast of Brazil. T1D patients were stratified according to the presence autoimmune thyroiditis and celiac disease. Allele and genotype frequencies of IL18 SNPs were Hardy-Weinberg equilibrium in patients and controls. The allele -137G and the haplotype -656G/-607C/-137G were more frequent in T1D patients (OR=1.82 and 1.97, respectively) then in healthy controls. However, those SNPs were not associated with the age of T1D onset as well as with the insurgence of AITD and/or CD in concomitant with T1D patients. Our findings suggest an association between IL18 promoter SNPs and susceptibility to T1D in Brazilian patients. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/23557801/Interleukin_18__IL18__gene_promoter_polymorphisms_are_associated_with_type_1_diabetes_mellitus_in_Brazilian_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(13)00106-3 DB - PRIME DP - Unbound Medicine ER -