TY - JOUR T1 - Increased recognition of non-O157 Shiga toxin-producing Escherichia coli infections in the United States during 2000-2010: epidemiologic features and comparison with E. coli O157 infections. AU - Gould,L Hannah, AU - Mody,Rajal K, AU - Ong,Kanyin L, AU - Clogher,Paula, AU - Cronquist,Alicia B, AU - Garman,Katie N, AU - Lathrop,Sarah, AU - Medus,Carlota, AU - Spina,Nancy L, AU - Webb,Tameka H, AU - White,Patricia L, AU - Wymore,Katie, AU - Gierke,Ruth E, AU - Mahon,Barbara E, AU - Griffin,Patricia M, AU - ,, Y1 - 2013/04/06/ PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2015/3/31/medline SP - 453 EP - 60 JF - Foodborne pathogens and disease JO - Foodborne Pathog Dis VL - 10 IS - 5 N2 - BACKGROUND: Shiga toxin-producing Escherichia coli (STEC) are an important cause of diarrhea and the major cause of postdiarrheal hemolytic uremic syndrome. Non-O157 STEC infections are being recognized with greater frequency because of changing laboratory practices. METHODS: Foodborne Diseases Active Surveillance Network (FoodNet) site staff conducted active, population-based surveillance for laboratory-confirmed STEC infections. We assessed frequency and incidence of STEC infections by serogroup and examined and compared demographic factors, clinical characteristics, and frequency of international travel among patients. RESULTS: During 2000-2010, FoodNet sites reported 2006 cases of non-O157 STEC infection and 5688 cases of O157 STEC infections. The number of reported non-O157 STEC infections increased from an incidence of 0.12 per 100,000 population in 2000 to 0.95 per 100,000 in 2010; while the rate of O157 STEC infections decreased from 2.17 to 0.95 per 100,000. Among non-O157 STEC, six serogroups were most commonly reported: O26 (26%), O103 (22%), O111 (19%), O121 (6%), O45 (5%), and O145 (4%). Non-O157 STEC infections were more common among Hispanics, and infections were less severe than those caused by O157 STEC, but this varied by serogroup. Fewer non-O157 STEC infections were associated with outbreaks (7% versus 20% for O157), while more were associated with international travel (14% versus 3% for O157). CONCLUSIONS: Improved understanding of the epidemiologic features of non-O157 STEC infections can inform food safety and other prevention efforts. To detect both O157 and non-O157 STEC infections, clinical laboratories should routinely and simultaneously test all stool specimens submitted for diagnosis of acute community-acquired diarrhea for O157 STEC and for Shiga toxin and ensure that isolates are sent to a public health laboratory for serotyping and subtyping. SN - 1556-7125 UR - https://www.unboundmedicine.com/medline/citation/23560425/Increased_recognition_of_non_O157_Shiga_toxin_producing_Escherichia_coli_infections_in_the_United_States_during_2000_2010:_epidemiologic_features_and_comparison_with_E__coli_O157_infections_ L2 - https://www.liebertpub.com/doi/10.1089/fpd.2012.1401?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -