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Effect of a preoperative gabapentin on postoperative analgesia in patients with inflammatory bowel disease following major bowel surgery: a randomized, placebo-controlled trial.
Pain Pract. 2014 Feb; 14(2):132-9.PP

Abstract

BACKGROUND

Postoperative pain management for patients with inflammatory bowel disease (IBD) can be challenging. These patients have a high tolerance to pain medication, and relative contraindications to the use of epidural analgesia, limiting the pain management options. We evaluated the effect of a single preoperative gabapentin dose on opioid consumption for patients with IBD undergoing abdominal surgery. Secondary outcomes were postoperative pain scores, opioid-related side effects, and patient's length of hospital stay.

METHODS

Following Research Ethics Board approval and informed written consent, patients were randomly allocated into 2 groups receiving either 600 mg of oral gabapentin or placebo 1 hour before the surgery. A blinded anesthesiologist recorded pain scores at rest and movement twice daily for 2 postoperative days. Also recorded were opioid consumption, time of return of bowel function, time to discharge, and opioid-related side effects on the opioid-related symptom distress scale (ORSDS).

RESULTS

Seventy-two patients completed the study. The difference in opioid consumption (P = 0.4169) and pain scores measured at rest and movement on all 4 postoperative visits was not statistically significant. There was no significant difference between gabapentin and placebo on all the 11 symptoms reported on the ORSDS. There was a slight increase in length of hospital stay in the placebo group, but the return of bowel function was similar between the groups.

CONCLUSIONS

This study examined the effect of a single preoperative administration of gabapentin in patients with IBD undergoing major bowel surgery. Our results suggest a single preoperative oral dose of gabapentin 600 mg does not reduce postoperative pain scores, opioid consumption, or opioid-related side effects.

Authors+Show Affiliations

Department of Anaesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23560500

Citation

Siddiqui, Naveed T., et al. "Effect of a Preoperative Gabapentin On Postoperative Analgesia in Patients With Inflammatory Bowel Disease Following Major Bowel Surgery: a Randomized, Placebo-controlled Trial." Pain Practice : the Official Journal of World Institute of Pain, vol. 14, no. 2, 2014, pp. 132-9.
Siddiqui NT, Fischer H, Guerina L, et al. Effect of a preoperative gabapentin on postoperative analgesia in patients with inflammatory bowel disease following major bowel surgery: a randomized, placebo-controlled trial. Pain Pract. 2014;14(2):132-9.
Siddiqui, N. T., Fischer, H., Guerina, L., & Friedman, Z. (2014). Effect of a preoperative gabapentin on postoperative analgesia in patients with inflammatory bowel disease following major bowel surgery: a randomized, placebo-controlled trial. Pain Practice : the Official Journal of World Institute of Pain, 14(2), 132-9. https://doi.org/10.1111/papr.12058
Siddiqui NT, et al. Effect of a Preoperative Gabapentin On Postoperative Analgesia in Patients With Inflammatory Bowel Disease Following Major Bowel Surgery: a Randomized, Placebo-controlled Trial. Pain Pract. 2014;14(2):132-9. PubMed PMID: 23560500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a preoperative gabapentin on postoperative analgesia in patients with inflammatory bowel disease following major bowel surgery: a randomized, placebo-controlled trial. AU - Siddiqui,Naveed T, AU - Fischer,Howard, AU - Guerina,Laarni, AU - Friedman,Zeev, Y1 - 2013/04/08/ PY - 2012/06/05/received PY - 2013/02/20/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2014/9/18/medline KW - abdominal surgery KW - acute pain service KW - gabapentin KW - pain KW - patient-controlled intravenous analgesia KW - postoperative KW - preoperative administration KW - randomized controlled trial SP - 132 EP - 9 JF - Pain practice : the official journal of World Institute of Pain JO - Pain Pract VL - 14 IS - 2 N2 - BACKGROUND: Postoperative pain management for patients with inflammatory bowel disease (IBD) can be challenging. These patients have a high tolerance to pain medication, and relative contraindications to the use of epidural analgesia, limiting the pain management options. We evaluated the effect of a single preoperative gabapentin dose on opioid consumption for patients with IBD undergoing abdominal surgery. Secondary outcomes were postoperative pain scores, opioid-related side effects, and patient's length of hospital stay. METHODS: Following Research Ethics Board approval and informed written consent, patients were randomly allocated into 2 groups receiving either 600 mg of oral gabapentin or placebo 1 hour before the surgery. A blinded anesthesiologist recorded pain scores at rest and movement twice daily for 2 postoperative days. Also recorded were opioid consumption, time of return of bowel function, time to discharge, and opioid-related side effects on the opioid-related symptom distress scale (ORSDS). RESULTS: Seventy-two patients completed the study. The difference in opioid consumption (P = 0.4169) and pain scores measured at rest and movement on all 4 postoperative visits was not statistically significant. There was no significant difference between gabapentin and placebo on all the 11 symptoms reported on the ORSDS. There was a slight increase in length of hospital stay in the placebo group, but the return of bowel function was similar between the groups. CONCLUSIONS: This study examined the effect of a single preoperative administration of gabapentin in patients with IBD undergoing major bowel surgery. Our results suggest a single preoperative oral dose of gabapentin 600 mg does not reduce postoperative pain scores, opioid consumption, or opioid-related side effects. SN - 1533-2500 UR - https://www.unboundmedicine.com/medline/citation/23560500/Effect_of_a_preoperative_gabapentin_on_postoperative_analgesia_in_patients_with_inflammatory_bowel_disease_following_major_bowel_surgery:_a_randomized_placebo_controlled_trial_ L2 - https://doi.org/10.1111/papr.12058 DB - PRIME DP - Unbound Medicine ER -