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Asymmetric one-pot sequential Mannich/hydroamination reaction by organo- and gold catalysts: synthesis of spiro[pyrrolidin-3,2'-oxindole] derivatives.
Org Lett. 2013 Apr 19; 15(8):1846-9.OL

Abstract

An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chen X
School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, 22 Hankou Road, Nanjing 210093, PR China.
Chen H
No affiliation info available
Ji X
No affiliation info available
Jiang H
No affiliation info available
Yao ZJ
No affiliation info available
Liu H
No affiliation info available

MeSH

CatalysisGoldIndolesMolecular StructureOxindolesSpiro CompoundsStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23560725

Citation

Chen, Xianjie, et al. "Asymmetric One-pot Sequential Mannich/hydroamination Reaction By Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2'-oxindole] Derivatives." Organic Letters, vol. 15, no. 8, 2013, pp. 1846-9.
Chen X, Chen H, Ji X, et al. Asymmetric one-pot sequential Mannich/hydroamination reaction by organo- and gold catalysts: synthesis of spiro[pyrrolidin-3,2'-oxindole] derivatives. Org Lett. 2013;15(8):1846-9.
Chen, X., Chen, H., Ji, X., Jiang, H., Yao, Z. J., & Liu, H. (2013). Asymmetric one-pot sequential Mannich/hydroamination reaction by organo- and gold catalysts: synthesis of spiro[pyrrolidin-3,2'-oxindole] derivatives. Organic Letters, 15(8), 1846-9. https://doi.org/10.1021/ol4004542
Chen X, et al. Asymmetric One-pot Sequential Mannich/hydroamination Reaction By Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2'-oxindole] Derivatives. Org Lett. 2013 Apr 19;15(8):1846-9. PubMed PMID: 23560725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetric one-pot sequential Mannich/hydroamination reaction by organo- and gold catalysts: synthesis of spiro[pyrrolidin-3,2'-oxindole] derivatives. AU - Chen,Xianjie, AU - Chen,Hui, AU - Ji,Xun, AU - Jiang,Hualiang, AU - Yao,Zhu-Jun, AU - Liu,Hong, Y1 - 2013/04/05/ PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2013/8/31/medline SP - 1846 EP - 9 JF - Organic letters JO - Org Lett VL - 15 IS - 8 N2 - An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee). SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/23560725/Asymmetric_one_pot_sequential_Mannich/hydroamination_reaction_by_organo__and_gold_catalysts:_synthesis_of_spiro[pyrrolidin_32'_oxindole]_derivatives_ L2 - https://doi.org/10.1021/ol4004542 DB - PRIME DP - Unbound Medicine ER -