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Comparison of injection dose force, accuracy and precision among three growth hormone injection devices.
Expert Rev Med Devices 2013; 10(3):321-7ER

Abstract

Successful growth hormone (GH) therapy requires sustained treatment adherence, usually over long periods of time. However, adherence rates are often poor and this can lead to suboptimal clinical outcomes. Developments in GH injection devices aim to help improve adherence by making daily injections easier. Injection force is an important practical aspect for patients receiving daily GH injections, particularly for patients with small hands or reduced hand strength due to muscle weakness. Norditropin FlexPro (Novo Nordisk A/S, Bagsværd, Denmark) is an easy-to-use GH injection pen device, shown here to have reduced injection force, similar dose accuracy and greater dose precision compared with Norditropin NordiFlex (Novo Nordisk A/S) and Genotropin GoQuick (Pfizer Inc., NY, USA). Easier injections may enable patients to self-administer GH more readily and therefore potentially may help improve adherence and clinical outcome.

Authors+Show Affiliations

Novo Nordisk A/S, Vandtaarnsvej 114 Søborg, DK 2860, Denmark. amk@novonordisk.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23560872

Citation

Kappelgaard, Anne-Marie, and Niels-Åge Hansen. "Comparison of Injection Dose Force, Accuracy and Precision Among Three Growth Hormone Injection Devices." Expert Review of Medical Devices, vol. 10, no. 3, 2013, pp. 321-7.
Kappelgaard AM, Hansen NÅ. Comparison of injection dose force, accuracy and precision among three growth hormone injection devices. Expert Rev Med Devices. 2013;10(3):321-7.
Kappelgaard, A. M., & Hansen, N. Å. (2013). Comparison of injection dose force, accuracy and precision among three growth hormone injection devices. Expert Review of Medical Devices, 10(3), pp. 321-7. doi:10.1586/erd.13.12.
Kappelgaard AM, Hansen NÅ. Comparison of Injection Dose Force, Accuracy and Precision Among Three Growth Hormone Injection Devices. Expert Rev Med Devices. 2013;10(3):321-7. PubMed PMID: 23560872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of injection dose force, accuracy and precision among three growth hormone injection devices. AU - Kappelgaard,Anne-Marie, AU - Hansen,Niels-Åge, Y1 - 2013/04/08/ PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2014/2/22/medline SP - 321 EP - 7 JF - Expert review of medical devices JO - Expert Rev Med Devices VL - 10 IS - 3 N2 - Successful growth hormone (GH) therapy requires sustained treatment adherence, usually over long periods of time. However, adherence rates are often poor and this can lead to suboptimal clinical outcomes. Developments in GH injection devices aim to help improve adherence by making daily injections easier. Injection force is an important practical aspect for patients receiving daily GH injections, particularly for patients with small hands or reduced hand strength due to muscle weakness. Norditropin FlexPro (Novo Nordisk A/S, Bagsværd, Denmark) is an easy-to-use GH injection pen device, shown here to have reduced injection force, similar dose accuracy and greater dose precision compared with Norditropin NordiFlex (Novo Nordisk A/S) and Genotropin GoQuick (Pfizer Inc., NY, USA). Easier injections may enable patients to self-administer GH more readily and therefore potentially may help improve adherence and clinical outcome. SN - 1745-2422 UR - https://www.unboundmedicine.com/medline/citation/23560872/Comparison_of_injection_dose_force_accuracy_and_precision_among_three_growth_hormone_injection_devices_ L2 - http://www.tandfonline.com/doi/full/10.1586/erd.13.12 DB - PRIME DP - Unbound Medicine ER -