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Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction.
J Neurol Sci. 2013 Jun 15; 329(1-2):23-8.JN

Abstract

BACKGROUND

Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex.

METHODS

The authors evaluated the relationship between frontostriatal dopaminergic function and cognitive performance, especially cognitive processing speed by performing [(18)F]fluorodopa PET and computerized tests of automatic and controlled cognitive processing speed (CogniSpeed) in 23 newly diagnosed and unmedicated PD patients and 14 controls.

RESULTS

PD patients were slower than the controls in all the CogniSpeed measures studied. The Fdopa uptake in caudate nucleus correlated negatively with slowing on all the tests. Slower performance in relatively automatic processes measured by choice reaction tasks as well as in more controlled processes measured by a calculation task was related to reduced Fdopa uptake in the anterior cingulate gyrus. The reduced dopaminergic function in the thalamus was associated with the slower performance in the subtraction test.

CONCLUSION

Our study indicates that dopaminergic dysfunction within neural networks linking striatum to prefrontal cortex is involved in the slowing of both automatic and controlled cognitive processing in PD patients.

Authors+Show Affiliations

Turku PET Centre, Turku University Hospital, Turku, Finland. peanjo@utu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23561982

Citation

Jokinen, Pekka, et al. "Cognitive Slowing in Parkinson's Disease Is Related to Frontostriatal Dopaminergic Dysfunction." Journal of the Neurological Sciences, vol. 329, no. 1-2, 2013, pp. 23-8.
Jokinen P, Karrasch M, Brück A, et al. Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction. J Neurol Sci. 2013;329(1-2):23-8.
Jokinen, P., Karrasch, M., Brück, A., Johansson, J., Bergman, J., & Rinne, J. O. (2013). Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction. Journal of the Neurological Sciences, 329(1-2), 23-8. https://doi.org/10.1016/j.jns.2013.03.006
Jokinen P, et al. Cognitive Slowing in Parkinson's Disease Is Related to Frontostriatal Dopaminergic Dysfunction. J Neurol Sci. 2013 Jun 15;329(1-2):23-8. PubMed PMID: 23561982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction. AU - Jokinen,Pekka, AU - Karrasch,Mira, AU - Brück,Anna, AU - Johansson,Jarkko, AU - Bergman,Jörgen, AU - Rinne,Juha O, Y1 - 2013/04/03/ PY - 2012/08/29/received PY - 2013/02/07/revised PY - 2013/03/06/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2013/11/10/medline SP - 23 EP - 8 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 329 IS - 1-2 N2 - BACKGROUND: Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex. METHODS: The authors evaluated the relationship between frontostriatal dopaminergic function and cognitive performance, especially cognitive processing speed by performing [(18)F]fluorodopa PET and computerized tests of automatic and controlled cognitive processing speed (CogniSpeed) in 23 newly diagnosed and unmedicated PD patients and 14 controls. RESULTS: PD patients were slower than the controls in all the CogniSpeed measures studied. The Fdopa uptake in caudate nucleus correlated negatively with slowing on all the tests. Slower performance in relatively automatic processes measured by choice reaction tasks as well as in more controlled processes measured by a calculation task was related to reduced Fdopa uptake in the anterior cingulate gyrus. The reduced dopaminergic function in the thalamus was associated with the slower performance in the subtraction test. CONCLUSION: Our study indicates that dopaminergic dysfunction within neural networks linking striatum to prefrontal cortex is involved in the slowing of both automatic and controlled cognitive processing in PD patients. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/23561982/Cognitive_slowing_in_Parkinson's_disease_is_related_to_frontostriatal_dopaminergic_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(13)00127-5 DB - PRIME DP - Unbound Medicine ER -