Tags

Type your tag names separated by a space and hit enter

Impaired glucose homeostasis in non-diabetic Greek hypertensives with diabetes family history. Effect of the obesity status.
J Am Soc Hypertens 2013 Jul-Aug; 7(4):294-304JA

Abstract

Arterial hypertension (AH) and diabetes mellitus (DM) are established cardiovascular risk factors. Impaired glucose homeostasis (IGH; impaired fasting glucose or/and impaired glucose tolerance) or pre-diabetes, obesity, and DM family history identify individuals at risk for type 2 DM in whom preventive interventions are necessary. The aim of this study was to determine the glycemic profile in non-diabetic Greek adult hypertensive men and women according to DM family history and the obesity status. Diabetes family history, obesity markers (waist-to-hip ratio, WHR; body mass index, BMI), glycemic parameters (fasting and 2-hour post-load plasma glucose, if necessary; glycated hemoglobin, HbA1c; fasting insulin), insulin resistance indices (homeostasis model assessment, HOMA; quantitative insulin sensitivity check index, QUICKI; Bennett; McAuley), and IGH prevalence were determined in a large cohort of 11,540 Greek hypertensives referred to our institutions. Positive DM family history was associated with elevated fasting glucose (98.6 ± 13.1 vs 96.5 ± 12.3 mg/dL), HbA1c (5.58% ± 0.49% vs 5.50% ± 0.46%), fasting insulin (9.74 ± 4.20 vs 9.21 ± 3.63 μU/mL) and HOMA (2.43 ± 1.19 vs 2.24 ± 1.01) values, lower QUICKI (0.342 ± 0.025 vs 0.345 ± 0.023), Bennett (0.285 ± 0.081 vs 0.292 ± 0.078) and McAuley (6.73 ± 3.43 vs 6.95 ± 3.44) values, and higher IGH prevalence (45.3% vs 38.7%); P < .01 for all comparisons. The difference in the prevalence of IGH according to DM family history was significant (P < .01) in both genders and every WHR and BMI subgroup (except for women with BMI <20 kg/m(2)). Non-diabetic hypertensives with positive DM family history present with higher IGH prevalence and worse glycemic indices levels compared with those with negative family history, especially in the higher WHR/BMI subgroups.

Authors+Show Affiliations

First Cardiology Department, University of Athens Medical School, Hippokration Hospital, 11527, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23562108

Citation

Vyssoulis, Gregory P., et al. "Impaired Glucose Homeostasis in Non-diabetic Greek Hypertensives With Diabetes Family History. Effect of the Obesity Status." Journal of the American Society of Hypertension : JASH, vol. 7, no. 4, 2013, pp. 294-304.
Vyssoulis GP, Liakos CI, Karpanou EA, et al. Impaired glucose homeostasis in non-diabetic Greek hypertensives with diabetes family history. Effect of the obesity status. J Am Soc Hypertens. 2013;7(4):294-304.
Vyssoulis, G. P., Liakos, C. I., Karpanou, E. A., Triantafyllou, A. I., Michaelides, A. P., Tzamou, V. E., ... Stefanadis, C. I. (2013). Impaired glucose homeostasis in non-diabetic Greek hypertensives with diabetes family history. Effect of the obesity status. Journal of the American Society of Hypertension : JASH, 7(4), pp. 294-304. doi:10.1016/j.jash.2013.02.007.
Vyssoulis GP, et al. Impaired Glucose Homeostasis in Non-diabetic Greek Hypertensives With Diabetes Family History. Effect of the Obesity Status. J Am Soc Hypertens. 2013;7(4):294-304. PubMed PMID: 23562108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired glucose homeostasis in non-diabetic Greek hypertensives with diabetes family history. Effect of the obesity status. AU - Vyssoulis,Gregory P, AU - Liakos,Charalampos I, AU - Karpanou,Eva A, AU - Triantafyllou,Athanasios I, AU - Michaelides,Andreas P, AU - Tzamou,Vanessa E, AU - Markou,Maria I, AU - Stefanadis,Christodoulos I, Y1 - 2013/04/03/ PY - 2013/01/30/received PY - 2013/02/14/revised PY - 2013/02/18/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2014/3/13/medline KW - Arterial hypertension KW - diabetes family history KW - impaired glucose homeostasis KW - obesity KW - pre-diabetes KW - type 2 diabetes SP - 294 EP - 304 JF - Journal of the American Society of Hypertension : JASH JO - J Am Soc Hypertens VL - 7 IS - 4 N2 - Arterial hypertension (AH) and diabetes mellitus (DM) are established cardiovascular risk factors. Impaired glucose homeostasis (IGH; impaired fasting glucose or/and impaired glucose tolerance) or pre-diabetes, obesity, and DM family history identify individuals at risk for type 2 DM in whom preventive interventions are necessary. The aim of this study was to determine the glycemic profile in non-diabetic Greek adult hypertensive men and women according to DM family history and the obesity status. Diabetes family history, obesity markers (waist-to-hip ratio, WHR; body mass index, BMI), glycemic parameters (fasting and 2-hour post-load plasma glucose, if necessary; glycated hemoglobin, HbA1c; fasting insulin), insulin resistance indices (homeostasis model assessment, HOMA; quantitative insulin sensitivity check index, QUICKI; Bennett; McAuley), and IGH prevalence were determined in a large cohort of 11,540 Greek hypertensives referred to our institutions. Positive DM family history was associated with elevated fasting glucose (98.6 ± 13.1 vs 96.5 ± 12.3 mg/dL), HbA1c (5.58% ± 0.49% vs 5.50% ± 0.46%), fasting insulin (9.74 ± 4.20 vs 9.21 ± 3.63 μU/mL) and HOMA (2.43 ± 1.19 vs 2.24 ± 1.01) values, lower QUICKI (0.342 ± 0.025 vs 0.345 ± 0.023), Bennett (0.285 ± 0.081 vs 0.292 ± 0.078) and McAuley (6.73 ± 3.43 vs 6.95 ± 3.44) values, and higher IGH prevalence (45.3% vs 38.7%); P < .01 for all comparisons. The difference in the prevalence of IGH according to DM family history was significant (P < .01) in both genders and every WHR and BMI subgroup (except for women with BMI <20 kg/m(2)). Non-diabetic hypertensives with positive DM family history present with higher IGH prevalence and worse glycemic indices levels compared with those with negative family history, especially in the higher WHR/BMI subgroups. SN - 1878-7436 UR - https://www.unboundmedicine.com/medline/citation/23562108/Impaired_glucose_homeostasis_in_non_diabetic_Greek_hypertensives_with_diabetes_family_history__Effect_of_the_obesity_status_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1933-1711(13)00018-1 DB - PRIME DP - Unbound Medicine ER -