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Analysis of 4-MEC in biological and non-biological material--three case reports.
Forensic Sci Int. 2013 May 10; 228(1-3):e11-5.FS

Abstract

4-Methylethcathinone (4-MEC) is a designer drug that is structurally similar to mephedrone. This substance was identified in many drug seizures analyzed in the Institute of Forensic Research (IFR). This paper describes three of the first cases in which both powders and biological material were secured at the same time and delivered to the IFR for toxicological analysis. The first case concerned a man who died in a car crash. The second case describes a death associated with multiple-drug intake, including 4-MEC. In this case, however, the death was the result of an overdose of para-methoxyamphetamine (PMA). In the third case, the man was arrested for possession of illicit drugs. Analysis of powders was carried out using gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography with diode array detection (HPLC-DAD). The purity of 4-MEC found in powder samples was 51% and 78%. Analyses of biological material were carried out using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 4-MEC was found in blood samples at concentrations of 46, 56 and 152 ng/mL.

Authors+Show Affiliations

Institute of Forensic Research, Westerplatte 9, 31-033 Krakow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23562144

Citation

Gil, Dominika, et al. "Analysis of 4-MEC in Biological and Non-biological Material--three Case Reports." Forensic Science International, vol. 228, no. 1-3, 2013, pp. e11-5.
Gil D, Adamowicz P, Skulska A, et al. Analysis of 4-MEC in biological and non-biological material--three case reports. Forensic Sci Int. 2013;228(1-3):e11-5.
Gil, D., Adamowicz, P., Skulska, A., Tokarczyk, B., & Stanaszek, R. (2013). Analysis of 4-MEC in biological and non-biological material--three case reports. Forensic Science International, 228(1-3), e11-5. https://doi.org/10.1016/j.forsciint.2013.03.011
Gil D, et al. Analysis of 4-MEC in Biological and Non-biological Material--three Case Reports. Forensic Sci Int. 2013 May 10;228(1-3):e11-5. PubMed PMID: 23562144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of 4-MEC in biological and non-biological material--three case reports. AU - Gil,Dominika, AU - Adamowicz,Piotr, AU - Skulska,Agnieszka, AU - Tokarczyk,Bogdan, AU - Stanaszek,Roman, Y1 - 2013/04/03/ PY - 2012/12/20/received PY - 2013/03/01/revised PY - 2013/03/09/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2013/12/25/medline SP - e11 EP - 5 JF - Forensic science international JO - Forensic Sci. Int. VL - 228 IS - 1-3 N2 - 4-Methylethcathinone (4-MEC) is a designer drug that is structurally similar to mephedrone. This substance was identified in many drug seizures analyzed in the Institute of Forensic Research (IFR). This paper describes three of the first cases in which both powders and biological material were secured at the same time and delivered to the IFR for toxicological analysis. The first case concerned a man who died in a car crash. The second case describes a death associated with multiple-drug intake, including 4-MEC. In this case, however, the death was the result of an overdose of para-methoxyamphetamine (PMA). In the third case, the man was arrested for possession of illicit drugs. Analysis of powders was carried out using gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography with diode array detection (HPLC-DAD). The purity of 4-MEC found in powder samples was 51% and 78%. Analyses of biological material were carried out using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 4-MEC was found in blood samples at concentrations of 46, 56 and 152 ng/mL. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/23562144/Analysis_of_4_MEC_in_biological_and_non_biological_material__three_case_reports_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(13)00164-3 DB - PRIME DP - Unbound Medicine ER -