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Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case.
Spine J. 2013 Aug; 13(8):e49-54.SJ

Abstract

BACKGROUND CONTEXT

Ependymoma associated with multiple endocrine neoplasia type 1 (MEN-1) is an extremely rare clinical entity. To the best of our knowledge, only five cases of ependymoma associated with MEN-1 have been previously described. Furthermore, there has been no case of tanycytic ependymoma of the filum terminale associated with MEN-1.

PURPOSE

The present case report illustrates a 53-year-old man with tanycytic ependymoma of the filum terminale associated with MEN-1. We review the literature on ependymoma with MEN-1 and tanycytic ependymoma of the cauda equina region and also discuss the risk of recurrence.

STUDY DESIGN

A case report.

METHODS

The patient presented with complaints of nocturnal pain in the lower back, accompanied by numbness around the anus and intermittent claudication for approximately 1 year. Magnetic resonance imaging (MRI) identified an intradural-enhancing, large mass lesion at the level from Th12 to L2 vertebrae, with a cranial cystic lesion.

RESULTS

Open-door laminoplasty of the Th12, L1, and L2 and en bloc tumor resection with thickened filum terminale were performed. Histopathologic examination of the tumor specimens showed tanycytic ependymoma (World Health Organization Classification Grade II). At the time of the 2-year and 8-month follow-up examination, MRI did not show tumor recurrence.

CONCLUSIONS

This is the first reported case of this clinical entity. A careful follow-up of patients with this unusual tumor is strongly recommended.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. funatoru3@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23562332

Citation

Funayama, Toru, et al. "Tanycytic Ependymoma of the Filum Terminale Associated With Multiple Endocrine Neoplasia Type 1: First Reported Case." The Spine Journal : Official Journal of the North American Spine Society, vol. 13, no. 8, 2013, pp. e49-54.
Funayama T, Sakane M, Yoshizawa T, et al. Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. Spine J. 2013;13(8):e49-54.
Funayama, T., Sakane, M., Yoshizawa, T., Takeuchi, Y., & Ochiai, N. (2013). Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. The Spine Journal : Official Journal of the North American Spine Society, 13(8), e49-54. https://doi.org/10.1016/j.spinee.2013.02.066
Funayama T, et al. Tanycytic Ependymoma of the Filum Terminale Associated With Multiple Endocrine Neoplasia Type 1: First Reported Case. Spine J. 2013;13(8):e49-54. PubMed PMID: 23562332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. AU - Funayama,Toru, AU - Sakane,Masataka, AU - Yoshizawa,Tomohiro, AU - Takeuchi,Yousuke, AU - Ochiai,Naoyuki, Y1 - 2013/04/03/ PY - 2012/03/21/received PY - 2013/02/25/revised PY - 2013/02/25/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2014/3/22/medline KW - Conus medullaris KW - Filum terminale KW - Multiple endocrine neoplasia type 1 KW - Tanycytic ependymoma SP - e49 EP - 54 JF - The spine journal : official journal of the North American Spine Society JO - Spine J VL - 13 IS - 8 N2 - BACKGROUND CONTEXT: Ependymoma associated with multiple endocrine neoplasia type 1 (MEN-1) is an extremely rare clinical entity. To the best of our knowledge, only five cases of ependymoma associated with MEN-1 have been previously described. Furthermore, there has been no case of tanycytic ependymoma of the filum terminale associated with MEN-1. PURPOSE: The present case report illustrates a 53-year-old man with tanycytic ependymoma of the filum terminale associated with MEN-1. We review the literature on ependymoma with MEN-1 and tanycytic ependymoma of the cauda equina region and also discuss the risk of recurrence. STUDY DESIGN: A case report. METHODS: The patient presented with complaints of nocturnal pain in the lower back, accompanied by numbness around the anus and intermittent claudication for approximately 1 year. Magnetic resonance imaging (MRI) identified an intradural-enhancing, large mass lesion at the level from Th12 to L2 vertebrae, with a cranial cystic lesion. RESULTS: Open-door laminoplasty of the Th12, L1, and L2 and en bloc tumor resection with thickened filum terminale were performed. Histopathologic examination of the tumor specimens showed tanycytic ependymoma (World Health Organization Classification Grade II). At the time of the 2-year and 8-month follow-up examination, MRI did not show tumor recurrence. CONCLUSIONS: This is the first reported case of this clinical entity. A careful follow-up of patients with this unusual tumor is strongly recommended. SN - 1878-1632 UR - https://www.unboundmedicine.com/medline/citation/23562332/Tanycytic_ependymoma_of_the_filum_terminale_associated_with_multiple_endocrine_neoplasia_type_1:_first_reported_case_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1529-9430(13)00266-0 DB - PRIME DP - Unbound Medicine ER -