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Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats.
Neurosci Lett. 2013 May 24; 543:115-20.NL

Abstract

Xanthoceraside, a triterpenoid saponin extracted from the fruit husks of Xanthoceras sorbifolia Bunge, has been shown to reverse the cognitive deficits observed in several Alzheimer's disease (AD) animal models. Increasing evidence suggests the involvement of the insulin signaling pathway in neurodegenerative disorders such as AD. Thus, we used an AD animal model of cognitive impairment induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) to test the effects of xanthoceraside on behavioral impairments and insulin signaling mechanisms. In our present study, memory impairment was assessed using the Morris water maze test. The expression of IR, IGF-1R and Raf-1/ERK/CREB was tested by western blotting. The STZ group showed memory deficits in the Morris water maze test and significant decreases in IR and IGF-1R protein levels in the hippocampus. Xanthoceraside treatment significantly rescued memory deficits, as well as IR and IGF-1R protein expression levels. STZ inhibited the Ras/ERK signaling cascade and decreased the phosphorylation of CREB; these effects were also attenuated by xanthoceraside treatment. These results suggest the potential use of xanthoceraside for the treatment of neurodegenerative disorders in which brain insulin signaling may be involved.

Authors+Show Affiliations

Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang 110016, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23562514

Citation

Liu, Peng, et al. "Xanthoceraside Attenuates Learning and Memory Deficits Via Improving Insulin Signaling in STZ-induced AD Rats." Neuroscience Letters, vol. 543, 2013, pp. 115-20.
Liu P, Zou L, Jiao Q, et al. Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. Neurosci Lett. 2013;543:115-20.
Liu, P., Zou, L., Jiao, Q., Chi, T., Ji, X., Qi, Y., Xu, Q., & Wang, L. (2013). Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. Neuroscience Letters, 543, 115-20. https://doi.org/10.1016/j.neulet.2013.02.065
Liu P, et al. Xanthoceraside Attenuates Learning and Memory Deficits Via Improving Insulin Signaling in STZ-induced AD Rats. Neurosci Lett. 2013 May 24;543:115-20. PubMed PMID: 23562514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. AU - Liu,Peng, AU - Zou,Libo, AU - Jiao,Qing, AU - Chi,Tianyan, AU - Ji,Xuefei, AU - Qi,Yue, AU - Xu,Qian, AU - Wang,Lihua, Y1 - 2013/04/03/ PY - 2012/12/29/received PY - 2013/02/07/revised PY - 2013/02/24/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2013/9/7/medline SP - 115 EP - 20 JF - Neuroscience letters JO - Neurosci. Lett. VL - 543 N2 - Xanthoceraside, a triterpenoid saponin extracted from the fruit husks of Xanthoceras sorbifolia Bunge, has been shown to reverse the cognitive deficits observed in several Alzheimer's disease (AD) animal models. Increasing evidence suggests the involvement of the insulin signaling pathway in neurodegenerative disorders such as AD. Thus, we used an AD animal model of cognitive impairment induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) to test the effects of xanthoceraside on behavioral impairments and insulin signaling mechanisms. In our present study, memory impairment was assessed using the Morris water maze test. The expression of IR, IGF-1R and Raf-1/ERK/CREB was tested by western blotting. The STZ group showed memory deficits in the Morris water maze test and significant decreases in IR and IGF-1R protein levels in the hippocampus. Xanthoceraside treatment significantly rescued memory deficits, as well as IR and IGF-1R protein expression levels. STZ inhibited the Ras/ERK signaling cascade and decreased the phosphorylation of CREB; these effects were also attenuated by xanthoceraside treatment. These results suggest the potential use of xanthoceraside for the treatment of neurodegenerative disorders in which brain insulin signaling may be involved. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/23562514/Xanthoceraside_attenuates_learning_and_memory_deficits_via_improving_insulin_signaling_in_STZ_induced_AD_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(13)00259-0 DB - PRIME DP - Unbound Medicine ER -