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Associations of prenatal exposure to phenols with birth outcomes.
Environ Pollut. 2013 Jul; 178:115-20.EP

Abstract

Many phenols are known to mimic or antagonize hormonal activities and may adversely affect fetal growth. A study of 567 pregnant women was conducted to investigate the relationship between prenatal phenol exposure and birth outcomes, including birth weight, length, and gestational age. We measured the concentrations of bisphenol A, benzophenone-3, 4-n-octylphenol and 4-n-nonylphenol in maternal urine and examine their association with birth outcomes. Categories of urinary benzophenone-3 concentration were associated with decreased gestational age in all infants (p for trend = 0.03). Between middle and low exposure groups, we also found bisphenol A was negatively associated with gestational duration (βadjusted = -0.48 week; 95% confidence interval: -0.91, -0.05). After stratification by gender, we found the consistent results in infant boys with those in all infants, but we did not observe significant association for girls. In conclusion, we found prenatal phenol exposure was sex-specifically related to birth outcomes.

Authors+Show Affiliations

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23562958

Citation

Tang, Rong, et al. "Associations of Prenatal Exposure to Phenols With Birth Outcomes." Environmental Pollution (Barking, Essex : 1987), vol. 178, 2013, pp. 115-20.
Tang R, Chen MJ, Ding GD, et al. Associations of prenatal exposure to phenols with birth outcomes. Environ Pollut. 2013;178:115-20.
Tang, R., Chen, M. J., Ding, G. D., Chen, X. J., Han, X. M., Zhou, K., Chen, L. M., Xia, Y. K., Tian, Y., & Wang, X. R. (2013). Associations of prenatal exposure to phenols with birth outcomes. Environmental Pollution (Barking, Essex : 1987), 178, 115-20. https://doi.org/10.1016/j.envpol.2013.03.023
Tang R, et al. Associations of Prenatal Exposure to Phenols With Birth Outcomes. Environ Pollut. 2013;178:115-20. PubMed PMID: 23562958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of prenatal exposure to phenols with birth outcomes. AU - Tang,Rong, AU - Chen,Min-Jian, AU - Ding,Guo-Dong, AU - Chen,Xiao-Jiao, AU - Han,Xiu-Mei, AU - Zhou,Kun, AU - Chen,Li-Mei, AU - Xia,Yan-Kai, AU - Tian,Ying, AU - Wang,Xin-Ru, Y1 - 2013/04/03/ PY - 2012/12/19/received PY - 2013/03/09/revised PY - 2013/03/12/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2013/8/31/medline SP - 115 EP - 20 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 178 N2 - Many phenols are known to mimic or antagonize hormonal activities and may adversely affect fetal growth. A study of 567 pregnant women was conducted to investigate the relationship between prenatal phenol exposure and birth outcomes, including birth weight, length, and gestational age. We measured the concentrations of bisphenol A, benzophenone-3, 4-n-octylphenol and 4-n-nonylphenol in maternal urine and examine their association with birth outcomes. Categories of urinary benzophenone-3 concentration were associated with decreased gestational age in all infants (p for trend = 0.03). Between middle and low exposure groups, we also found bisphenol A was negatively associated with gestational duration (βadjusted = -0.48 week; 95% confidence interval: -0.91, -0.05). After stratification by gender, we found the consistent results in infant boys with those in all infants, but we did not observe significant association for girls. In conclusion, we found prenatal phenol exposure was sex-specifically related to birth outcomes. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/23562958/Associations_of_prenatal_exposure_to_phenols_with_birth_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(13)00142-5 DB - PRIME DP - Unbound Medicine ER -