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Hepatitis E virus infection in immunosuppressed patients: natural history and therapy.
Semin Liver Dis. 2013 Feb; 33(1):62-70.SL

Abstract

Interest in hepatitis E virus (HEV) infection has increased over the last few years since chronic HEV infection was first reported in transplant patients. Chronic genotype-3 HEV infections have been now reported in patients with a solid-organ transplant, hematology disease, and in those who are human immunodeficiency virus-positive. Cases of HEV-related cirrhosis have been also reported. Furthermore, HEV associated extrahepatic manifestations, including neurologic symptoms, kidney injuries, and hematological disorders, have been reported. Antiviral therapies, such as pegylated-interferon and ribavirin, have been found to be efficient in treating HEV infection. The aim of this review is to summarize the incidence, natural history, risk factors, and treatment of HEV infections in immunosuppressed patients. HEV-induced extrahepatic manifestations are described.

Authors+Show Affiliations

Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France. kamar.n@chu-toulouse.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23564390

Citation

Kamar, Nassim, et al. "Hepatitis E Virus Infection in Immunosuppressed Patients: Natural History and Therapy." Seminars in Liver Disease, vol. 33, no. 1, 2013, pp. 62-70.
Kamar N, Rostaing L, Izopet J. Hepatitis E virus infection in immunosuppressed patients: natural history and therapy. Semin Liver Dis. 2013;33(1):62-70.
Kamar, N., Rostaing, L., & Izopet, J. (2013). Hepatitis E virus infection in immunosuppressed patients: natural history and therapy. Seminars in Liver Disease, 33(1), 62-70. https://doi.org/10.1055/s-0033-1338115
Kamar N, Rostaing L, Izopet J. Hepatitis E Virus Infection in Immunosuppressed Patients: Natural History and Therapy. Semin Liver Dis. 2013;33(1):62-70. PubMed PMID: 23564390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus infection in immunosuppressed patients: natural history and therapy. AU - Kamar,Nassim, AU - Rostaing,Lionel, AU - Izopet,Jacques, Y1 - 2013/04/05/ PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2013/11/1/medline SP - 62 EP - 70 JF - Seminars in liver disease JO - Semin Liver Dis VL - 33 IS - 1 N2 - Interest in hepatitis E virus (HEV) infection has increased over the last few years since chronic HEV infection was first reported in transplant patients. Chronic genotype-3 HEV infections have been now reported in patients with a solid-organ transplant, hematology disease, and in those who are human immunodeficiency virus-positive. Cases of HEV-related cirrhosis have been also reported. Furthermore, HEV associated extrahepatic manifestations, including neurologic symptoms, kidney injuries, and hematological disorders, have been reported. Antiviral therapies, such as pegylated-interferon and ribavirin, have been found to be efficient in treating HEV infection. The aim of this review is to summarize the incidence, natural history, risk factors, and treatment of HEV infections in immunosuppressed patients. HEV-induced extrahepatic manifestations are described. SN - 1098-8971 UR - https://www.unboundmedicine.com/medline/citation/23564390/Hepatitis_E_virus_infection_in_immunosuppressed_patients:_natural_history_and_therapy_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1338115 DB - PRIME DP - Unbound Medicine ER -