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Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
Hepatology 2013; 58(3):966-75Hep

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an obesity-related condition affecting over 50% of individuals in some populations and is expected to become the number one cause of liver disease worldwide by 2020. Common, robustly associated genetic variants in/near five genes were identified for hepatic steatosis, a quantifiable component of NAFLD, in European ancestry individuals. Here we tested whether these variants were associated with hepatic steatosis in African- and/or Hispanic-Americans and fine-mapped the observed association signals. We measured hepatic steatosis using computed tomography in five African American (n = 3,124) and one Hispanic American (n = 849) cohorts. All analyses controlled for variation in age, age(2) , gender, alcoholic drinks, and population substructure. Heritability of hepatic steatosis was estimated in three cohorts. Variants in/near PNPLA3, NCAN, LYPLAL1, GCKR, and PPP1R3B were tested for association with hepatic steatosis using a regression framework in each cohort and meta-analyzed. Fine-mapping across African American cohorts was conducted using meta-analysis. African- and Hispanic-American cohorts were 33.9/37.5% male, with average age of 58.6/42.6 years and body mass index of 31.8/28.9 kg/m(2) , respectively. Hepatic steatosis was 0.20-0.34 heritable in African- and Hispanic-American families (P < 0.02 in each cohort). Variants in or near PNPLA3, NCAN, GCKR, PPP1R3B in African Americans and PNPLA3 and PPP1R3B in Hispanic Americans were significantly associated with hepatic steatosis; however, allele frequency and effect size varied across ancestries. Fine-mapping in African Americans highlighted missense variants at PNPLA3 and GCKR and redefined the association region at LYPLAL1.

CONCLUSION

Multiple genetic variants are associated with hepatic steatosis across ancestries. This explains a substantial proportion of the genetic predisposition in African- and Hispanic-Americans. Missense variants in PNPLA3 and GCKR are likely functional across multiple ancestries.

Authors+Show Affiliations

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis

Language

eng

PubMed ID

23564467

Citation

Palmer, Nicholette D., et al. "Characterization of European Ancestry Nonalcoholic Fatty Liver Disease-associated Variants in Individuals of African and Hispanic Descent." Hepatology (Baltimore, Md.), vol. 58, no. 3, 2013, pp. 966-75.
Palmer ND, Musani SK, Yerges-Armstrong LM, et al. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology. 2013;58(3):966-75.
Palmer, N. D., Musani, S. K., Yerges-Armstrong, L. M., Feitosa, M. F., Bielak, L. F., Hernaez, R., ... Speliotes, E. K. (2013). Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology (Baltimore, Md.), 58(3), pp. 966-75. doi:10.1002/hep.26440.
Palmer ND, et al. Characterization of European Ancestry Nonalcoholic Fatty Liver Disease-associated Variants in Individuals of African and Hispanic Descent. Hepatology. 2013;58(3):966-75. PubMed PMID: 23564467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. AU - Palmer,Nicholette D, AU - Musani,Solomon K, AU - Yerges-Armstrong,Laura M, AU - Feitosa,Mary F, AU - Bielak,Lawrence F, AU - Hernaez,Ruben, AU - Kahali,Bratati, AU - Carr,J Jeffrey, AU - Harris,Tamara B, AU - Jhun,Min A, AU - Kardia,Sharon L R, AU - Langefeld,Carl D, AU - Mosley,Thomas H,Jr AU - Norris,Jill M, AU - Smith,Albert V, AU - Taylor,Herman A, AU - Wagenknecht,Lynne E, AU - Liu,Jiankang, AU - Borecki,Ingrid B, AU - Peyser,Patricia A, AU - Speliotes,Elizabeth K, Y1 - 2013/07/16/ PY - 2012/11/21/received PY - 2013/04/03/accepted PY - 2013/4/9/entrez PY - 2013/4/9/pubmed PY - 2014/2/14/medline SP - 966 EP - 75 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 58 IS - 3 N2 - UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is an obesity-related condition affecting over 50% of individuals in some populations and is expected to become the number one cause of liver disease worldwide by 2020. Common, robustly associated genetic variants in/near five genes were identified for hepatic steatosis, a quantifiable component of NAFLD, in European ancestry individuals. Here we tested whether these variants were associated with hepatic steatosis in African- and/or Hispanic-Americans and fine-mapped the observed association signals. We measured hepatic steatosis using computed tomography in five African American (n = 3,124) and one Hispanic American (n = 849) cohorts. All analyses controlled for variation in age, age(2) , gender, alcoholic drinks, and population substructure. Heritability of hepatic steatosis was estimated in three cohorts. Variants in/near PNPLA3, NCAN, LYPLAL1, GCKR, and PPP1R3B were tested for association with hepatic steatosis using a regression framework in each cohort and meta-analyzed. Fine-mapping across African American cohorts was conducted using meta-analysis. African- and Hispanic-American cohorts were 33.9/37.5% male, with average age of 58.6/42.6 years and body mass index of 31.8/28.9 kg/m(2) , respectively. Hepatic steatosis was 0.20-0.34 heritable in African- and Hispanic-American families (P < 0.02 in each cohort). Variants in or near PNPLA3, NCAN, GCKR, PPP1R3B in African Americans and PNPLA3 and PPP1R3B in Hispanic Americans were significantly associated with hepatic steatosis; however, allele frequency and effect size varied across ancestries. Fine-mapping in African Americans highlighted missense variants at PNPLA3 and GCKR and redefined the association region at LYPLAL1. CONCLUSION: Multiple genetic variants are associated with hepatic steatosis across ancestries. This explains a substantial proportion of the genetic predisposition in African- and Hispanic-Americans. Missense variants in PNPLA3 and GCKR are likely functional across multiple ancestries. SN - 1527-3350 UR - https://www.unboundmedicine.com/medline/citation/23564467/Characterization_of_European_ancestry_nonalcoholic_fatty_liver_disease_associated_variants_in_individuals_of_African_and_Hispanic_descent_ L2 - https://doi.org/10.1002/hep.26440 DB - PRIME DP - Unbound Medicine ER -