Tags

Type your tag names separated by a space and hit enter

Analysis of induced sputum in the diagnosis of Pneumocystis carinii pneumonia.
Am J Med Sci. 1990 Jun; 299(6):386-91.AJ

Abstract

Sixty-two patients with possible AIDS-associated Pneumocystis carinii pneumonia (PCP) were studied to determine the diagnostic usefulness of sputum analysis and whether or not the results of sputum analysis are related to severity of disease. Induced sputum was stained with Gomori Methenamine silver and modified Wright Giemsa stains. Indicators of disease severity were: extent of chest roentgenographic infiltrate, serum lactic dehydrogenase activity, alveolar-arterial oxygen tension difference, and total blood lymphocyte count. All patients with sputum negative for Pneumocystis underwent bronchoscopy with bronchoalveolar lavage. Sputum analysis was 71% sensitive and 100% specific for the diagnosis of PCP. The negative predictive value of sputum analysis was 48%. There was no relationship between sputum results and the severity of PCP. This study led to the conclusions that sputum analysis is a sensitive, specific, rapid, and low-cost technique for the diagnosis of PCP, and that the sensitivity of sputum analysis for the detection of PCP is not affected by the severity of PCP.

Authors+Show Affiliations

Kirsch CM
Division of Respiratory Medicine, Santa Clara Valley Medical Center, San Jose, California 95128.
Azzi RL
No affiliation info available
Yenokida GG
No affiliation info available
Jensen WA
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultAgedBronchoalveolar Lavage FluidHumansL-Lactate DehydrogenaseLeukocyte CountMaleMiddle AgedPneumocystisPneumonia, PneumocystisPredictive Value of TestsReproducibility of ResultsSputum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2356852

Citation

Kirsch, C M., et al. "Analysis of Induced Sputum in the Diagnosis of Pneumocystis Carinii Pneumonia." The American Journal of the Medical Sciences, vol. 299, no. 6, 1990, pp. 386-91.
Kirsch CM, Azzi RL, Yenokida GG, et al. Analysis of induced sputum in the diagnosis of Pneumocystis carinii pneumonia. Am J Med Sci. 1990;299(6):386-91.
Kirsch, C. M., Azzi, R. L., Yenokida, G. G., & Jensen, W. A. (1990). Analysis of induced sputum in the diagnosis of Pneumocystis carinii pneumonia. The American Journal of the Medical Sciences, 299(6), 386-91.
Kirsch CM, et al. Analysis of Induced Sputum in the Diagnosis of Pneumocystis Carinii Pneumonia. Am J Med Sci. 1990;299(6):386-91. PubMed PMID: 2356852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of induced sputum in the diagnosis of Pneumocystis carinii pneumonia. AU - Kirsch,C M, AU - Azzi,R L, AU - Yenokida,G G, AU - Jensen,W A, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 386 EP - 91 JF - The American journal of the medical sciences JO - Am J Med Sci VL - 299 IS - 6 N2 - Sixty-two patients with possible AIDS-associated Pneumocystis carinii pneumonia (PCP) were studied to determine the diagnostic usefulness of sputum analysis and whether or not the results of sputum analysis are related to severity of disease. Induced sputum was stained with Gomori Methenamine silver and modified Wright Giemsa stains. Indicators of disease severity were: extent of chest roentgenographic infiltrate, serum lactic dehydrogenase activity, alveolar-arterial oxygen tension difference, and total blood lymphocyte count. All patients with sputum negative for Pneumocystis underwent bronchoscopy with bronchoalveolar lavage. Sputum analysis was 71% sensitive and 100% specific for the diagnosis of PCP. The negative predictive value of sputum analysis was 48%. There was no relationship between sputum results and the severity of PCP. This study led to the conclusions that sputum analysis is a sensitive, specific, rapid, and low-cost technique for the diagnosis of PCP, and that the sensitivity of sputum analysis for the detection of PCP is not affected by the severity of PCP. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/2356852/Analysis_of_induced_sputum_in_the_diagnosis_of_Pneumocystis_carinii_pneumonia_ DB - PRIME DP - Unbound Medicine ER -