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Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies.
Cancer Causes Control 2013; 24(6):1175-83CC

Abstract

BACKGROUND

Epidemiologic findings concerning the associations between intakes of heme iron and zinc and colorectal cancer (CRC) incidence yielded conflicting results. We aimed to investigate the associations by performing a meta-analysis of prospective studies.

METHODS

We conducted a literature search on PubMed and EMBASE databases up to December 2012 to identify the prospective studies that investigated the relationships between heme iron or zinc intake and risk of CRC. We also reviewed the bibliographies of the retrieved articles to identify additional studies. We used a random-effects model to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs).

RESULTS

Eight studies on heme iron intake and six studies on zinc intake met the inclusion criteria. The summary RR of CRC for the highest versus the lowest intake was 1.14 (95 % CI = 1.04-1.24) for heme iron and 0.83 (95 % CI = 0.72-0.94) for zinc, respectively. The observed associations were not significantly modified by subsites within the colorectum, sex, geographic area, study duration, the number of cases, or the range of intakes. In the dose-response analyses, the summary RR of CRC was 1.11 (95 % CI = 1.03-1.18) for heme iron intake of 1 mg/day, and 0.86 (95 % CI = 0.78-0.96) for zinc intake of 5 mg/day, respectively. There was little evidence of publication bias.

CONCLUSION

This meta-analysis suggests a significant positive dose-response association of heme iron intake and a significant inverse dose-response association of zinc intake with risk of CRC.

Authors+Show Affiliations

Department of Colorectal Surgery and Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23568532

Citation

Qiao, Lei, and Yong Feng. "Intakes of Heme Iron and Zinc and Colorectal Cancer Incidence: a Meta-analysis of Prospective Studies." Cancer Causes & Control : CCC, vol. 24, no. 6, 2013, pp. 1175-83.
Qiao L, Feng Y. Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies. Cancer Causes Control. 2013;24(6):1175-83.
Qiao, L., & Feng, Y. (2013). Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies. Cancer Causes & Control : CCC, 24(6), pp. 1175-83. doi:10.1007/s10552-013-0197-x.
Qiao L, Feng Y. Intakes of Heme Iron and Zinc and Colorectal Cancer Incidence: a Meta-analysis of Prospective Studies. Cancer Causes Control. 2013;24(6):1175-83. PubMed PMID: 23568532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies. AU - Qiao,Lei, AU - Feng,Yong, Y1 - 2013/04/09/ PY - 2012/12/24/received PY - 2013/03/21/accepted PY - 2013/4/10/entrez PY - 2013/4/10/pubmed PY - 2014/5/6/medline SP - 1175 EP - 83 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 6 N2 - BACKGROUND: Epidemiologic findings concerning the associations between intakes of heme iron and zinc and colorectal cancer (CRC) incidence yielded conflicting results. We aimed to investigate the associations by performing a meta-analysis of prospective studies. METHODS: We conducted a literature search on PubMed and EMBASE databases up to December 2012 to identify the prospective studies that investigated the relationships between heme iron or zinc intake and risk of CRC. We also reviewed the bibliographies of the retrieved articles to identify additional studies. We used a random-effects model to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs). RESULTS: Eight studies on heme iron intake and six studies on zinc intake met the inclusion criteria. The summary RR of CRC for the highest versus the lowest intake was 1.14 (95 % CI = 1.04-1.24) for heme iron and 0.83 (95 % CI = 0.72-0.94) for zinc, respectively. The observed associations were not significantly modified by subsites within the colorectum, sex, geographic area, study duration, the number of cases, or the range of intakes. In the dose-response analyses, the summary RR of CRC was 1.11 (95 % CI = 1.03-1.18) for heme iron intake of 1 mg/day, and 0.86 (95 % CI = 0.78-0.96) for zinc intake of 5 mg/day, respectively. There was little evidence of publication bias. CONCLUSION: This meta-analysis suggests a significant positive dose-response association of heme iron intake and a significant inverse dose-response association of zinc intake with risk of CRC. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23568532/Intakes_of_heme_iron_and_zinc_and_colorectal_cancer_incidence:_a_meta_analysis_of_prospective_studies_ L2 - https://doi.org/10.1007/s10552-013-0197-x DB - PRIME DP - Unbound Medicine ER -