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Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery.
Int J Nanomedicine. 2013; 8:1269-83.IJ

Abstract

In this systematic and comprehensive study, inhalation powders of the polypeptide immunosuppressant drug - cyclosporine A - for lung delivery as dry powder inhalers (DPIs) were successfully designed, developed, and optimized. Several spray drying pump rates were rationally chosen. Comprehensive physicochemical characterization and imaging was carried out using scanning electron microscopy, hot-stage microscopy, differential scanning calorimetry, powder X-ray diffraction, Karl Fischer titration, laser size diffraction, and gravimetric vapor sorption. Aerosol dispersion performance was conducted using a next generation impactor with a Food and Drug Administration-approved DPI device. These DPIs displayed excellent aerosol dispersion performance with high values in emitted dose, respirable fraction, and fine particle fraction. In addition, novel multifunctional inhalation aerosol powder formulations of cyclosporine A with lung surfactant-mimic phospholipids were also successfully designed and developed by advanced organic solution cospray drying in closed mode. The lung surfactantmimic phospholipids were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-snglycero- 3-(phosphor-rac-1-glycerol). These cyclosporine A lung surfactant-mimic aerosol powder formulations were comprehensively characterized. Powder X-ray diffraction and differential scanning calorimetry confirmed that the phospholipid bilayer structure in the solid state was preserved following advanced organic solution spray drying in closed mode. These novel multifunctional inhalation powders were optimized for DPI delivery with excellent aerosol dispersion performance and high aerosol performance parameters.

Authors+Show Affiliations

Department of Pharmaceutical Sciences - Drug Development Division, University of Kentucky, Lexington, KY 40536-0596 , USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23569375

Citation

Wu, Xiao, et al. "Physicochemical Characterization and Aerosol Dispersion Performance of Organic Solution Advanced Spray-dried Cyclosporine a Multifunctional Particles for Dry Powder Inhalation Aerosol Delivery." International Journal of Nanomedicine, vol. 8, 2013, pp. 1269-83.
Wu X, Zhang W, Hayes D, et al. Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery. Int J Nanomedicine. 2013;8:1269-83.
Wu, X., Zhang, W., Hayes, D., & Mansour, H. M. (2013). Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery. International Journal of Nanomedicine, 8, 1269-83. https://doi.org/10.2147/IJN.S40904
Wu X, et al. Physicochemical Characterization and Aerosol Dispersion Performance of Organic Solution Advanced Spray-dried Cyclosporine a Multifunctional Particles for Dry Powder Inhalation Aerosol Delivery. Int J Nanomedicine. 2013;8:1269-83. PubMed PMID: 23569375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery. AU - Wu,Xiao, AU - Zhang,Weifen, AU - Hayes,Don,Jr AU - Mansour,Heidi M, Y1 - 2013/03/24/ PY - 2013/4/10/entrez PY - 2013/4/10/pubmed PY - 2014/1/31/medline KW - calcineurin inhibitor KW - dipalmitoylphosphatidylcholine (DPPC) KW - dipalmitoylphosphatidylglycerol (DPPG) KW - dry powder inhaler (DPI) KW - lung immunosuppression KW - lung surfactant KW - polypeptide drug KW - targeted lung immunosuppression SP - 1269 EP - 83 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 8 N2 - In this systematic and comprehensive study, inhalation powders of the polypeptide immunosuppressant drug - cyclosporine A - for lung delivery as dry powder inhalers (DPIs) were successfully designed, developed, and optimized. Several spray drying pump rates were rationally chosen. Comprehensive physicochemical characterization and imaging was carried out using scanning electron microscopy, hot-stage microscopy, differential scanning calorimetry, powder X-ray diffraction, Karl Fischer titration, laser size diffraction, and gravimetric vapor sorption. Aerosol dispersion performance was conducted using a next generation impactor with a Food and Drug Administration-approved DPI device. These DPIs displayed excellent aerosol dispersion performance with high values in emitted dose, respirable fraction, and fine particle fraction. In addition, novel multifunctional inhalation aerosol powder formulations of cyclosporine A with lung surfactant-mimic phospholipids were also successfully designed and developed by advanced organic solution cospray drying in closed mode. The lung surfactantmimic phospholipids were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-snglycero- 3-(phosphor-rac-1-glycerol). These cyclosporine A lung surfactant-mimic aerosol powder formulations were comprehensively characterized. Powder X-ray diffraction and differential scanning calorimetry confirmed that the phospholipid bilayer structure in the solid state was preserved following advanced organic solution spray drying in closed mode. These novel multifunctional inhalation powders were optimized for DPI delivery with excellent aerosol dispersion performance and high aerosol performance parameters. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/23569375/Physicochemical_characterization_and_aerosol_dispersion_performance_of_organic_solution_advanced_spray_dried_cyclosporine_A_multifunctional_particles_for_dry_powder_inhalation_aerosol_delivery_ L2 - https://dx.doi.org/10.2147/IJN.S40904 DB - PRIME DP - Unbound Medicine ER -