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[Influence of leukoaraiosis on the cognition of patients with Parkinson disease].
Zhonghua Yi Xue Za Zhi 2013; 93(3):177-81ZY

Abstract

OBJECTIVE

To explore the role of leukoaraiosis (LA) on the cognitive function in patients with Parkinson disease (PD).

METHODS

The cohort for this study included 63 patients with PD, whom were divided into 3 groups according to cognitive status:with intact cognition (PD-IC, n = 23), with mild cognitive impairment (PD-MCI, n = 23) and with dementia (PDD, n = 17). All the patients were recruited from the Department of Neurology, First Affiliated Hospital, Anhui Medical University between September 2011 and July 2012. The cognitive functions were evaluated by mini-metal state examination (MMSE), the Cambridge cognitive examination-Chinese version (CAMCOG-C), clinical dementia rating (CDR), clock drawing task (CDT) and verbal fluency test, etc. Depression symptoms were assessed by the geriatric depression scale (GDS) while motor symptoms by the Unified Parkinson's Disease Rating Scale-motor (UPDRS-motor) and the Hoehn and Yahr scale (HY). All the patients underwent magnetic resonance imaging (MRI) with a 3.0-T system. LA was rated using the semiquantitative visual rating system proposed by scheltens et al.

RESULTS

Both the PD-IC (2.43 ± 2.79) and PD-MCI (4.48 ± 4.33) groups showed significantly lower deep hyperintensities (DHs) scores than the PDD group (7.88 ± 6.69, P = 0.004 and 0.040, respectively), especially in frontal (1.09 ± 1.31; 1.83 ± 1.90; 3.24 ± 2.64, P < 0.05) and parietal areas (0.09 ± 0.29; 0.65 ± 1.03; 1.53 ± 2.32, P < 0.05). There were no significant differences in periventricular (1.57 ± 1.75; 2.52 ± 2.37; 3.24 ± 2.64, P > 0.05), basal ganglia (0.09 ± 0.42; 0.30 ± 0.77; 0.53 ± 1.33, P > 0.05) and infratentorial white matter hyperintensities scores (--; 0.13 ± 0.63; 0.18 ± 0.73, P > 0.05) among three groups. The DHs showed a significant correlation with age (P = 0.003), MMSE (P = 0.009), verbal fluency test (P = 0.009), orientation (P = 0.047) and executive function (P = 0.027) in CAMCOG-C. The multiple regression analysis showed that the MMSE scores were associated significantly with education (P < 0.001, β = 0.600), DHs (P = 0.001, β = -0.678) and HY (P = 0.035, β = -0.480). DHs were the most significantly associated with MMSE scores.

CONCLUSION

There was a significant correlation between DHs and multiple domain cognitive impairment in PD, especially in executive function. DHs, which were the most significantly variable associated with MMSE scores, may contribute to cognitive impairment in PD.

Authors+Show Affiliations

Department of Neurology, Anhui Medical University, Hefei, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23570589

Citation

Wang, Li, et al. "[Influence of Leukoaraiosis On the Cognition of Patients With Parkinson Disease]." Zhonghua Yi Xue Za Zhi, vol. 93, no. 3, 2013, pp. 177-81.
Wang L, Zhu XQ, Jiang CJ, et al. [Influence of leukoaraiosis on the cognition of patients with Parkinson disease]. Zhonghua Yi Xue Za Zhi. 2013;93(3):177-81.
Wang, L., Zhu, X. Q., Jiang, C. J., Chen, X. W., & Sun, Z. W. (2013). [Influence of leukoaraiosis on the cognition of patients with Parkinson disease]. Zhonghua Yi Xue Za Zhi, 93(3), pp. 177-81.
Wang L, et al. [Influence of Leukoaraiosis On the Cognition of Patients With Parkinson Disease]. Zhonghua Yi Xue Za Zhi. 2013 Jan 15;93(3):177-81. PubMed PMID: 23570589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of leukoaraiosis on the cognition of patients with Parkinson disease]. AU - Wang,Li, AU - Zhu,Xiao-qun, AU - Jiang,Chan-juan, AU - Chen,Xian-wen, AU - Sun,Zhong-wu, PY - 2013/4/11/entrez PY - 2013/4/11/pubmed PY - 2014/8/5/medline SP - 177 EP - 81 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 93 IS - 3 N2 - OBJECTIVE: To explore the role of leukoaraiosis (LA) on the cognitive function in patients with Parkinson disease (PD). METHODS: The cohort for this study included 63 patients with PD, whom were divided into 3 groups according to cognitive status:with intact cognition (PD-IC, n = 23), with mild cognitive impairment (PD-MCI, n = 23) and with dementia (PDD, n = 17). All the patients were recruited from the Department of Neurology, First Affiliated Hospital, Anhui Medical University between September 2011 and July 2012. The cognitive functions were evaluated by mini-metal state examination (MMSE), the Cambridge cognitive examination-Chinese version (CAMCOG-C), clinical dementia rating (CDR), clock drawing task (CDT) and verbal fluency test, etc. Depression symptoms were assessed by the geriatric depression scale (GDS) while motor symptoms by the Unified Parkinson's Disease Rating Scale-motor (UPDRS-motor) and the Hoehn and Yahr scale (HY). All the patients underwent magnetic resonance imaging (MRI) with a 3.0-T system. LA was rated using the semiquantitative visual rating system proposed by scheltens et al. RESULTS: Both the PD-IC (2.43 ± 2.79) and PD-MCI (4.48 ± 4.33) groups showed significantly lower deep hyperintensities (DHs) scores than the PDD group (7.88 ± 6.69, P = 0.004 and 0.040, respectively), especially in frontal (1.09 ± 1.31; 1.83 ± 1.90; 3.24 ± 2.64, P < 0.05) and parietal areas (0.09 ± 0.29; 0.65 ± 1.03; 1.53 ± 2.32, P < 0.05). There were no significant differences in periventricular (1.57 ± 1.75; 2.52 ± 2.37; 3.24 ± 2.64, P > 0.05), basal ganglia (0.09 ± 0.42; 0.30 ± 0.77; 0.53 ± 1.33, P > 0.05) and infratentorial white matter hyperintensities scores (--; 0.13 ± 0.63; 0.18 ± 0.73, P > 0.05) among three groups. The DHs showed a significant correlation with age (P = 0.003), MMSE (P = 0.009), verbal fluency test (P = 0.009), orientation (P = 0.047) and executive function (P = 0.027) in CAMCOG-C. The multiple regression analysis showed that the MMSE scores were associated significantly with education (P < 0.001, β = 0.600), DHs (P = 0.001, β = -0.678) and HY (P = 0.035, β = -0.480). DHs were the most significantly associated with MMSE scores. CONCLUSION: There was a significant correlation between DHs and multiple domain cognitive impairment in PD, especially in executive function. DHs, which were the most significantly variable associated with MMSE scores, may contribute to cognitive impairment in PD. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/23570589/[Influence_of_leukoaraiosis_on_the_cognition_of_patients_with_Parkinson_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2013&amp;vol=93&amp;issue=3&amp;fpage=177 DB - PRIME DP - Unbound Medicine ER -