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Rationale for the tinnitus retraining therapy trial.
Noise Health. 2013 Mar-Apr; 15(63):134-42.NH

Abstract

The Tinnitus Retraining Therapy Trial (TRTT) is a National Institutes of Health-sponsored, multi-centered, placebo-controlled, randomized trial evaluating the efficacy of tinnitus retraining therapy (TRT) and its component parts, directive counseling and sound therapy, as treatments for subjective debilitating tinnitus in the military. The TRTT will enroll 228 individuals at an allocation ratio of 1:1:1 to: (1) directive counseling and sound therapy using conventional sound generators; (2) directive counseling and placebo sound generators; or (3) standard of care as administered in the military. Study centers include a Study Chair's Office, a Data Coordinating Center, and six Military Clinical Centers with treatment and data collection standardized across all clinics. The primary outcome is change in Tinnitus Questionnaire (TQ) score assessed longitudinally at 3, 6, 12, and 18-month follow-up visits. Secondary outcomes include: Change in TQ sub-scales, Tinnitus Handicap Inventory, Tinnitus Functional Index, and TRT interview visual analog scale; audiometric and psychoacoustic measures; and change in quality of life. The TRTT will evaluate TRT efficacy by comparing TRT (directive counseling and conventional sound generators) with standard of care; directive counseling by comparing directive counseling plus placebo sound generators versus standard of care; and sound therapy by comparing conventional versus placebo sound generators. We hypothesize that full TRT will be more efficacious than standard of care, directive counseling and placebo sound generators more efficacious than standard of care, and conventional more efficacious than placebo sound generators in habituating the tinnitus awareness, annoyance, and impact on the study participant's life.

Authors+Show Affiliations

Department of Communicative Disorders, The University of Alabama, Box 870242, Tuscaloosa, AL 35487, USA. cformby@as.wa.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

23571304

Citation

Formby, Craig, et al. "Rationale for the Tinnitus Retraining Therapy Trial." Noise & Health, vol. 15, no. 63, 2013, pp. 134-42.
Formby C, Scherer R, TRTT Study Group. Rationale for the tinnitus retraining therapy trial. Noise Health. 2013;15(63):134-42.
Formby, C., & Scherer, R. (2013). Rationale for the tinnitus retraining therapy trial. Noise & Health, 15(63), 134-42. https://doi.org/10.4103/1463-1741.110299
Formby C, Scherer R, TRTT Study Group. Rationale for the Tinnitus Retraining Therapy Trial. Noise Health. 2013 Mar-Apr;15(63):134-42. PubMed PMID: 23571304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rationale for the tinnitus retraining therapy trial. AU - Formby,Craig, AU - Scherer,Roberta, AU - ,, PY - 2013/4/11/entrez PY - 2013/4/11/pubmed PY - 2013/7/26/medline SP - 134 EP - 42 JF - Noise & health JO - Noise Health VL - 15 IS - 63 N2 - The Tinnitus Retraining Therapy Trial (TRTT) is a National Institutes of Health-sponsored, multi-centered, placebo-controlled, randomized trial evaluating the efficacy of tinnitus retraining therapy (TRT) and its component parts, directive counseling and sound therapy, as treatments for subjective debilitating tinnitus in the military. The TRTT will enroll 228 individuals at an allocation ratio of 1:1:1 to: (1) directive counseling and sound therapy using conventional sound generators; (2) directive counseling and placebo sound generators; or (3) standard of care as administered in the military. Study centers include a Study Chair's Office, a Data Coordinating Center, and six Military Clinical Centers with treatment and data collection standardized across all clinics. The primary outcome is change in Tinnitus Questionnaire (TQ) score assessed longitudinally at 3, 6, 12, and 18-month follow-up visits. Secondary outcomes include: Change in TQ sub-scales, Tinnitus Handicap Inventory, Tinnitus Functional Index, and TRT interview visual analog scale; audiometric and psychoacoustic measures; and change in quality of life. The TRTT will evaluate TRT efficacy by comparing TRT (directive counseling and conventional sound generators) with standard of care; directive counseling by comparing directive counseling plus placebo sound generators versus standard of care; and sound therapy by comparing conventional versus placebo sound generators. We hypothesize that full TRT will be more efficacious than standard of care, directive counseling and placebo sound generators more efficacious than standard of care, and conventional more efficacious than placebo sound generators in habituating the tinnitus awareness, annoyance, and impact on the study participant's life. SN - 1463-1741 UR - https://www.unboundmedicine.com/medline/citation/23571304/Rationale_for_the_tinnitus_retraining_therapy_trial_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23571304/ DB - PRIME DP - Unbound Medicine ER -