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Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations.
Antimicrob Agents Chemother. 2013 Jun; 57(6):2882-6.AA

Abstract

Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.

Authors+Show Affiliations

Department of Microbiology, University College Cork, Cork, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23571539

Citation

Mathur, Harsh, et al. "Analysis of anti-Clostridium Difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, Both Singly and in Paired Combinations." Antimicrobial Agents and Chemotherapy, vol. 57, no. 6, 2013, pp. 2882-6.
Mathur H, O'Connor PM, Hill C, et al. Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations. Antimicrob Agents Chemother. 2013;57(6):2882-6.
Mathur, H., O'Connor, P. M., Hill, C., Cotter, P. D., & Ross, R. P. (2013). Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations. Antimicrobial Agents and Chemotherapy, 57(6), 2882-6. https://doi.org/10.1128/AAC.00261-13
Mathur H, et al. Analysis of anti-Clostridium Difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, Both Singly and in Paired Combinations. Antimicrob Agents Chemother. 2013;57(6):2882-6. PubMed PMID: 23571539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations. AU - Mathur,Harsh, AU - O'Connor,Paula M, AU - Hill,Colin, AU - Cotter,Paul D, AU - Ross,R Paul, Y1 - 2013/04/09/ PY - 2013/4/11/entrez PY - 2013/4/11/pubmed PY - 2013/10/26/medline SP - 2882 EP - 6 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 57 IS - 6 N2 - Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/23571539/Analysis_of_anti_Clostridium_difficile_activity_of_thuricin_CD_vancomycin_metronidazole_ramoplanin_and_actagardine_both_singly_and_in_paired_combinations_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=23571539 DB - PRIME DP - Unbound Medicine ER -