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Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction.
J Neural Transm (Vienna). 2013 Oct; 120(10):1479-89.JN

Abstract

The risk of cerebral infarction (CI) is contributed to the combination of environmental influences and genetic factors. The Apolipoprotein E (APOE) gene polymorphism as a risk factor in CI has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. The purpose of this study was to identify association between the APOE ε2/ε3/ε4 polymorphism and the development of CI. Published relevant case-control studies were collected from electronic databases. Data were combined using odds ratio (OR) with 95% confidence interval (CI). Totally, 29 studies published from 1997 to 2012, involving 2,737 CI cases and 2,689 controls in Chinese population were subjected to final analysis. The pooled results suggested that CI subjects carrying ε4 allele had an increased risk for CI (ε4 vs. ε3: OR = 2.50, 95% CI 1.98-3.16, P < 0.001, ε4 carriers vs. E3E3 genotype: OR = 2.82, 95% CI 2.16-3.67, P < 0.001), compared with those carrying ε3 allele. However, carriers of APOE ε2 allele had no significant increased risk for CI, compared with those carrying ε3 allele. Potential publication bias was observed in the genetic model of ε4 versus ε3, but the results might not be affected deeply by the publication bias. Using the trim and fill method, the adjusted risk estimate for ε4 allele versus ε3 allele was attenuated but remained significant (OR = 2.00, 95% CI 1.59-2.53, P < 0.001), suggesting the stability of our results. Taken together, our study suggests that APOE ε4 allele is associated with an increased risk of developing CI in Chinese population.

Authors+Show Affiliations

Department of Neurology, Anhui Provincial Hospital Affiliated to Anhui Medical University, No. 17 LuJiang Road, Hefei, 230001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23571734

Citation

Wang, Qian-you, et al. "Meta-analysis of APOE Ε2/ε3/ε4 Polymorphism and Cerebral Infarction." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 120, no. 10, 2013, pp. 1479-89.
Wang QY, Wang WJ, Wu L, et al. Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction. J Neural Transm (Vienna). 2013;120(10):1479-89.
Wang, Q. Y., Wang, W. J., Wu, L., Liu, L., & Han, L. Z. (2013). Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction. Journal of Neural Transmission (Vienna, Austria : 1996), 120(10), 1479-89. https://doi.org/10.1007/s00702-013-1019-8
Wang QY, et al. Meta-analysis of APOE Ε2/ε3/ε4 Polymorphism and Cerebral Infarction. J Neural Transm (Vienna). 2013;120(10):1479-89. PubMed PMID: 23571734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction. AU - Wang,Qian-you, AU - Wang,Wen-jing, AU - Wu,Lei, AU - Liu,Liang, AU - Han,Li-zhu, Y1 - 2013/04/10/ PY - 2012/12/05/received PY - 2013/03/29/accepted PY - 2013/4/11/entrez PY - 2013/4/11/pubmed PY - 2014/4/24/medline SP - 1479 EP - 89 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 120 IS - 10 N2 - The risk of cerebral infarction (CI) is contributed to the combination of environmental influences and genetic factors. The Apolipoprotein E (APOE) gene polymorphism as a risk factor in CI has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. The purpose of this study was to identify association between the APOE ε2/ε3/ε4 polymorphism and the development of CI. Published relevant case-control studies were collected from electronic databases. Data were combined using odds ratio (OR) with 95% confidence interval (CI). Totally, 29 studies published from 1997 to 2012, involving 2,737 CI cases and 2,689 controls in Chinese population were subjected to final analysis. The pooled results suggested that CI subjects carrying ε4 allele had an increased risk for CI (ε4 vs. ε3: OR = 2.50, 95% CI 1.98-3.16, P < 0.001, ε4 carriers vs. E3E3 genotype: OR = 2.82, 95% CI 2.16-3.67, P < 0.001), compared with those carrying ε3 allele. However, carriers of APOE ε2 allele had no significant increased risk for CI, compared with those carrying ε3 allele. Potential publication bias was observed in the genetic model of ε4 versus ε3, but the results might not be affected deeply by the publication bias. Using the trim and fill method, the adjusted risk estimate for ε4 allele versus ε3 allele was attenuated but remained significant (OR = 2.00, 95% CI 1.59-2.53, P < 0.001), suggesting the stability of our results. Taken together, our study suggests that APOE ε4 allele is associated with an increased risk of developing CI in Chinese population. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/23571734/Meta_analysis_of_APOE_��2/��3/��4_polymorphism_and_cerebral_infarction_ L2 - https://doi.org/10.1007/s00702-013-1019-8 DB - PRIME DP - Unbound Medicine ER -