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[Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)].
Dongwuxue Yanjiu. 2013 Apr; 34(2):89-96.DY

Abstract

The pig-tailed macaque is an important non-human primate experimental animal model that has been widely used in the research of AIDS and other diseases. Pig-tailed macaques include Mentawai macaques (Macaca pagensis), Sunda pig-tailed macaques (M. nemestrina) and northern pig-tailed macaques (M. leonina). Northern pig-tailed macaques inhabit China and surrounding Southeast Asia countries. To our knowledge, no reports have been published regarding the hematology and blood chemistry parameters of northern pig-tailed macaques, which are important for the objective evaluation of experimental results. We measured and analyzed 18 hematology parameters and 13 blood chemistry parameters in juvenile (aged 2-4 years) and adult (aged 5-10 years) northern pig-tailed macaques. We found that red blood cells, hemoglobin and alkaline phosphatase values were lower in female macaques than male macaques in both juvenile and adult groups. White blood cells, lymphocyte, monocytes, platelet distribution width, cholesterol, aspartate aminotransferase and alkaline phosphatase values were higher in juvenile macaques than adult macaques, while creatinine and triglycerides values were lower in juvenile macaques. Mean corpuscular hemoglobin and creatinine values were positively correlated with weight in juvenile groups. In adult groups, mean corpuscular hemoglobin, percentage of granulocyte, hemoglobin and creatinine were also positively correlated with weight, and lymphocyte, percentage of lymphocyte, red cell distribution width, aspartate aminotransferase and cholesterol values were negatively correlated with weight. The results suggest that age, gender and weight of northern pig-tailed macaques affected their hematology and blood chemistry parameters. This hematological and blood chemistry study has great significance in biomedical research and animal models using northern pig-tailed macaque as an experimental animal.

Authors+Show Affiliations

Chinese Academy of Sciences, Kunming, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

chi

PubMed ID

23572357

Citation

Pang, Wei, et al. "[Measurement and Analysis of Hematology and Blood Chemistry Parameters in Northern Pig-tailed Macaques (Macaca Leonina)]." Dong Wu Xue Yan Jiu = Zoological Research, vol. 34, no. 2, 2013, pp. 89-96.
Pang W, Lü LB, Wang Y, et al. [Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)]. Zool Res. 2013;34(2):89-96.
Pang, W., Lü, L. B., Wang, Y., Li, G., Huang, D. T., Lei, A. H., Zhang, G. H., & Zheng, Y. T. (2013). [Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)]. Dong Wu Xue Yan Jiu = Zoological Research, 34(2), 89-96. https://doi.org/10.3724/SP.J.1141.2013.02089
Pang W, et al. [Measurement and Analysis of Hematology and Blood Chemistry Parameters in Northern Pig-tailed Macaques (Macaca Leonina)]. Zool Res. 2013;34(2):89-96. PubMed PMID: 23572357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)]. AU - Pang,Wei, AU - Lü,Long-Bao, AU - Wang,Yun, AU - Li,Gui, AU - Huang,Dong-Ti, AU - Lei,Ai-Hua, AU - Zhang,Gao-Hong, AU - Zheng,Yong-Tang, PY - 2013/4/11/entrez PY - 2013/4/11/pubmed PY - 2013/9/18/medline KW - Blood chemistry KW - Experimental animal KW - Hematology KW - Northern pig-tailed macaque (Macaca leonina) KW - Parameters KW - Primates SP - 89 EP - 96 JF - Dong wu xue yan jiu = Zoological research JO - Zool. Res. VL - 34 IS - 2 N2 - The pig-tailed macaque is an important non-human primate experimental animal model that has been widely used in the research of AIDS and other diseases. Pig-tailed macaques include Mentawai macaques (Macaca pagensis), Sunda pig-tailed macaques (M. nemestrina) and northern pig-tailed macaques (M. leonina). Northern pig-tailed macaques inhabit China and surrounding Southeast Asia countries. To our knowledge, no reports have been published regarding the hematology and blood chemistry parameters of northern pig-tailed macaques, which are important for the objective evaluation of experimental results. We measured and analyzed 18 hematology parameters and 13 blood chemistry parameters in juvenile (aged 2-4 years) and adult (aged 5-10 years) northern pig-tailed macaques. We found that red blood cells, hemoglobin and alkaline phosphatase values were lower in female macaques than male macaques in both juvenile and adult groups. White blood cells, lymphocyte, monocytes, platelet distribution width, cholesterol, aspartate aminotransferase and alkaline phosphatase values were higher in juvenile macaques than adult macaques, while creatinine and triglycerides values were lower in juvenile macaques. Mean corpuscular hemoglobin and creatinine values were positively correlated with weight in juvenile groups. In adult groups, mean corpuscular hemoglobin, percentage of granulocyte, hemoglobin and creatinine were also positively correlated with weight, and lymphocyte, percentage of lymphocyte, red cell distribution width, aspartate aminotransferase and cholesterol values were negatively correlated with weight. The results suggest that age, gender and weight of northern pig-tailed macaques affected their hematology and blood chemistry parameters. This hematological and blood chemistry study has great significance in biomedical research and animal models using northern pig-tailed macaque as an experimental animal. SN - 0254-5853 UR - https://www.unboundmedicine.com/medline/citation/23572357/[Measurement_and_analysis_of_hematology_and_blood_chemistry_parameters_in_northern_pig_tailed_macaques__Macaca_leonina_]_ L2 - http://www.zoores.ac.cn/EN/abstract/abstract3309.shtml DB - PRIME DP - Unbound Medicine ER -