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Atovaquone and proguanil hydrochloride for treatment of malaria.
J Travel Med. 1999 May; 6 Suppl 1:S18-20.JT

Abstract

BACKGROUND

Safe and effective new drugs are needed for treatment of malaria. Atovaquone and proguanil hydrochloride is a new antimalarial combination that has recently become available in many countries.

METHODS

Data from clinical trials evaluating atovaquone/proguanil for treatment of malaria were reviewed.

RESULTS

In 10 open-label clinical trials, treatment of uncomplicated falciparum malaria with 1000 mg atovaquone and 400 mg proguanil hydrochloride (or the equivalent based on body weight in patients < or = 40 kg) once daily for 3 days achieved cure in 514 of 521 (99%) evaluable patients. Treatment-limiting adverse events occurred in < 1% of patients (vomiting in four, anaphylaxis in one). Atovaquone/proguanil has been used to provide radical cure of asymptomatic Plasmodium falciparum infections prior to initiation of placebo-controlled trials of malaria prophylaxis. Recurrent parasitemia occurred within 28 days in 0 of 99 subjects who subsequently received prophylaxis with atovaquone/proguanil and 1 of 81 subjects who subsequently received placebo. Atovaquone/proguanil is also effective for treatment of malaria caused by the other three Plasmodium species that cause malaria in humans. For treatment of vivax malaria, therapy with primaquine in addition to atovaquone/proguanil is needed to prevent relapse from latent hepatic hypnozoites.

CONCLUSION

Atovaquone and proguanil hydrochloride is a safe and effective combination for treatment of malaria.

Authors+Show Affiliations

Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23573548

Citation

Kremsner, P G., et al. "Atovaquone and Proguanil Hydrochloride for Treatment of Malaria." Journal of Travel Medicine, vol. 6 Suppl 1, 1999, pp. S18-20.
Kremsner PG, Looareesuwan S, Chulay JD. Atovaquone and proguanil hydrochloride for treatment of malaria. J Travel Med. 1999;6 Suppl 1:S18-20.
Kremsner, P. G., Looareesuwan, S., & Chulay, J. D. (1999). Atovaquone and proguanil hydrochloride for treatment of malaria. Journal of Travel Medicine, 6 Suppl 1, S18-20.
Kremsner PG, Looareesuwan S, Chulay JD. Atovaquone and Proguanil Hydrochloride for Treatment of Malaria. J Travel Med. 1999;6 Suppl 1:S18-20. PubMed PMID: 23573548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atovaquone and proguanil hydrochloride for treatment of malaria. AU - Kremsner,P G, AU - Looareesuwan,S, AU - Chulay,J D, PY - 2013/4/11/entrez PY - 1999/5/1/pubmed PY - 2013/6/29/medline SP - S18 EP - 20 JF - Journal of travel medicine JO - J Travel Med VL - 6 Suppl 1 N2 - BACKGROUND: Safe and effective new drugs are needed for treatment of malaria. Atovaquone and proguanil hydrochloride is a new antimalarial combination that has recently become available in many countries. METHODS: Data from clinical trials evaluating atovaquone/proguanil for treatment of malaria were reviewed. RESULTS: In 10 open-label clinical trials, treatment of uncomplicated falciparum malaria with 1000 mg atovaquone and 400 mg proguanil hydrochloride (or the equivalent based on body weight in patients < or = 40 kg) once daily for 3 days achieved cure in 514 of 521 (99%) evaluable patients. Treatment-limiting adverse events occurred in < 1% of patients (vomiting in four, anaphylaxis in one). Atovaquone/proguanil has been used to provide radical cure of asymptomatic Plasmodium falciparum infections prior to initiation of placebo-controlled trials of malaria prophylaxis. Recurrent parasitemia occurred within 28 days in 0 of 99 subjects who subsequently received prophylaxis with atovaquone/proguanil and 1 of 81 subjects who subsequently received placebo. Atovaquone/proguanil is also effective for treatment of malaria caused by the other three Plasmodium species that cause malaria in humans. For treatment of vivax malaria, therapy with primaquine in addition to atovaquone/proguanil is needed to prevent relapse from latent hepatic hypnozoites. CONCLUSION: Atovaquone and proguanil hydrochloride is a safe and effective combination for treatment of malaria. SN - 1195-1982 UR - https://www.unboundmedicine.com/medline/citation/23573548/Atovaquone_and_proguanil_hydrochloride_for_treatment_of_malaria_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1195-1982&amp;date=1999&amp;volume=6&amp;issue=&amp;spage=S18 DB - PRIME DP - Unbound Medicine ER -