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Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan.
Int J Clin Pharm. 2013 Jun; 35(3):339-43.IJ

Abstract

BACKGROUND

Due to their favorable toxicity profile and lack of interactions, benzodiazepines have been proposed as prophylaxis of busulfan induced seizures. Although they are broadly used in pediatric patients, the experience in adults is limited.

OBJECTIVE

To describe the effectivity for seizure prophylaxis of the fixed 1 mg every 8 h (q8h) i.v. clonazepam dosing in adult patients receiving high dose i.v busulfan, as part of the hematopoietic progenitors transplant conditioning regimen.

METHODS

Retrospective, observational study, from January 2008 to June 2012. Patients over 15 years old that had received high dose busulfan and prophylaxis with 1 mg q8h i.v. clonazepam from 12 h before the first dose of busulfan to 24 h after the last one were selected. The primary endpoint was the occurrence of seizures until 72 h after finishing conditioning.

RESULTS

Thirty-three patients, 13 female and 20 male, median age 48, were included. Autologous transplant was performed in 17 patients and allogeneic in 16. Busulfan dose was 3.2 mg/kg every 24 h with a variable duration of 2-4 days. No seizures were recorded.

CONCLUSION

The 1 mg q8h i.v. clonazepam fixed schedule is easily administered and is effective for the prevention of high dose busulfan induced seizures in adult patients.

Authors+Show Affiliations

Hospital Pharmacy Department, Virgen de la Arrixaca Hospital, Murcia, Spain. msacramento.diaz@carm.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23575621

Citation

Diaz-Carrasco, Maria Sacramento, et al. "Clonazepam for Seizure Prophylaxis in Adult Patients Treated With High Dose Busulfan." International Journal of Clinical Pharmacy, vol. 35, no. 3, 2013, pp. 339-43.
Diaz-Carrasco MS, Olmos R, Blanquer M, et al. Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan. Int J Clin Pharm. 2013;35(3):339-43.
Diaz-Carrasco, M. S., Olmos, R., Blanquer, M., Velasco, J., Sánchez-Salinas, A., & Moraleda, J. M. (2013). Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan. International Journal of Clinical Pharmacy, 35(3), 339-43. https://doi.org/10.1007/s11096-013-9768-x
Diaz-Carrasco MS, et al. Clonazepam for Seizure Prophylaxis in Adult Patients Treated With High Dose Busulfan. Int J Clin Pharm. 2013;35(3):339-43. PubMed PMID: 23575621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan. AU - Diaz-Carrasco,Maria Sacramento, AU - Olmos,Raquel, AU - Blanquer,Miguel, AU - Velasco,Javier, AU - Sánchez-Salinas,Andrés, AU - Moraleda,José María, Y1 - 2013/04/11/ PY - 2012/11/19/received PY - 2013/04/01/accepted PY - 2013/4/12/entrez PY - 2013/4/12/pubmed PY - 2013/12/16/medline SP - 339 EP - 43 JF - International journal of clinical pharmacy JO - Int J Clin Pharm VL - 35 IS - 3 N2 - BACKGROUND: Due to their favorable toxicity profile and lack of interactions, benzodiazepines have been proposed as prophylaxis of busulfan induced seizures. Although they are broadly used in pediatric patients, the experience in adults is limited. OBJECTIVE: To describe the effectivity for seizure prophylaxis of the fixed 1 mg every 8 h (q8h) i.v. clonazepam dosing in adult patients receiving high dose i.v busulfan, as part of the hematopoietic progenitors transplant conditioning regimen. METHODS: Retrospective, observational study, from January 2008 to June 2012. Patients over 15 years old that had received high dose busulfan and prophylaxis with 1 mg q8h i.v. clonazepam from 12 h before the first dose of busulfan to 24 h after the last one were selected. The primary endpoint was the occurrence of seizures until 72 h after finishing conditioning. RESULTS: Thirty-three patients, 13 female and 20 male, median age 48, were included. Autologous transplant was performed in 17 patients and allogeneic in 16. Busulfan dose was 3.2 mg/kg every 24 h with a variable duration of 2-4 days. No seizures were recorded. CONCLUSION: The 1 mg q8h i.v. clonazepam fixed schedule is easily administered and is effective for the prevention of high dose busulfan induced seizures in adult patients. SN - 2210-7711 UR - https://www.unboundmedicine.com/medline/citation/23575621/Clonazepam_for_seizure_prophylaxis_in_adult_patients_treated_with_high_dose_busulfan_ L2 - https://dx.doi.org/10.1007/s11096-013-9768-x DB - PRIME DP - Unbound Medicine ER -