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Neurologic melioidosis in an imported pigtail macaque (Macaca nemestrina).
Vet Pathol. 2013 Nov; 50(6):1139-44.VP

Abstract

Burkholderia pseudomallei is the cause of melioidosis in humans and other animals. Disease occurs predominately in Asia and Australia. It is rare in North America, and affected people and animals typically have a history of travel to (in human cases) or importation from (in animal cases) endemic areas. We describe the gross and histopathologic features and the microbiologic, molecular, and immunohistochemical diagnoses of a case of acute meningoencephalomyelitis and focal pneumonia caused by B. pseudomallei infection in a pigtail macaque that was imported from Indonesia to the United States for research purposes. This bacterium has been classified as a Tier 1 overlap select agent and toxin; therefore, recognition of pathologic features, along with accurate and timely confirmatory diagnostic testing, in naturally infected research animals is imperative to protect animals and personnel in the laboratory animal setting.

Authors+Show Affiliations

Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G 32, Atlanta, GA 30333, USA. Email: jritter@cdc.gov.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23576240

Citation

Ritter, J M., et al. "Neurologic Melioidosis in an Imported Pigtail Macaque (Macaca Nemestrina)." Veterinary Pathology, vol. 50, no. 6, 2013, pp. 1139-44.
Ritter JM, Sanchez S, Jones TL, et al. Neurologic melioidosis in an imported pigtail macaque (Macaca nemestrina). Vet Pathol. 2013;50(6):1139-44.
Ritter, J. M., Sanchez, S., Jones, T. L., Zaki, S. R., & Drew, C. P. (2013). Neurologic melioidosis in an imported pigtail macaque (Macaca nemestrina). Veterinary Pathology, 50(6), 1139-44. https://doi.org/10.1177/0300985813485249
Ritter JM, et al. Neurologic Melioidosis in an Imported Pigtail Macaque (Macaca Nemestrina). Vet Pathol. 2013;50(6):1139-44. PubMed PMID: 23576240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurologic melioidosis in an imported pigtail macaque (Macaca nemestrina). AU - Ritter,J M, AU - Sanchez,S, AU - Jones,T L, AU - Zaki,S R, AU - Drew,C P, Y1 - 2013/04/10/ PY - 2013/4/12/entrez PY - 2013/4/12/pubmed PY - 2015/5/13/medline KW - Burkholderia pseudomallei KW - PCR KW - immunohistochemistry KW - macaque KW - melioidosis KW - meningoencephalomyelitis KW - neurologic SP - 1139 EP - 44 JF - Veterinary pathology JO - Vet Pathol VL - 50 IS - 6 N2 - Burkholderia pseudomallei is the cause of melioidosis in humans and other animals. Disease occurs predominately in Asia and Australia. It is rare in North America, and affected people and animals typically have a history of travel to (in human cases) or importation from (in animal cases) endemic areas. We describe the gross and histopathologic features and the microbiologic, molecular, and immunohistochemical diagnoses of a case of acute meningoencephalomyelitis and focal pneumonia caused by B. pseudomallei infection in a pigtail macaque that was imported from Indonesia to the United States for research purposes. This bacterium has been classified as a Tier 1 overlap select agent and toxin; therefore, recognition of pathologic features, along with accurate and timely confirmatory diagnostic testing, in naturally infected research animals is imperative to protect animals and personnel in the laboratory animal setting. SN - 1544-2217 UR - https://www.unboundmedicine.com/medline/citation/23576240/Neurologic_melioidosis_in_an_imported_pigtail_macaque__Macaca_nemestrina__ L2 - https://journals.sagepub.com/doi/10.1177/0300985813485249?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -