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Development of a portable mass spectrometer characterized by discontinuous sample gas introduction, a low-pressure dielectric barrier discharge ionization source, and a vacuumed headspace technique.
Anal Chem. 2013 May 21; 85(10):5033-9.AC

Abstract

The present study has attempted to downscale a mass spectrometer in order to make it portable and enable onsite analysis with it. The development of a small mass spectrometer required the use of a compact pump whose displacement was small, decreasing the sensitivity of that spectrometer. To get high sensitivity with a small mass spectrometer, we have integrated novel techniques: a highly sensitive ionization source and efficient extraction of sample vapor. The low-pressure dielectric barrier discharge ionization (LP-DBDI) source made it possible to increase the conductance between the source and the mass analyzer, compared with ambient ionization sources, enhancing the efficiency of the ion transfer from the ionization source to the mass analyzer. We have also developed a vacuumed headspace method efficiently transporting the sample vapor to the ionization source. The sensitivity was further enhanced by also using a discontinuous sample gas introduction technique. A prototype portable mass spectrometer using those novel techniques was found to be sensitive enough to detect 0.1 ppm methamphetamine, 1 ppm amphetamine, 1 ppm 3,4-methylenedioxymethamphetamine, and 10 ppm cocaine in liquid.

Authors+Show Affiliations

Hitachi, Ltd., Central Research Laboratory, Kokubunji, Japan. shun.kumano.xe@hitachi.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23577896

Citation

Kumano, Shun, et al. "Development of a Portable Mass Spectrometer Characterized By Discontinuous Sample Gas Introduction, a Low-pressure Dielectric Barrier Discharge Ionization Source, and a Vacuumed Headspace Technique." Analytical Chemistry, vol. 85, no. 10, 2013, pp. 5033-9.
Kumano S, Sugiyama M, Yamada M, et al. Development of a portable mass spectrometer characterized by discontinuous sample gas introduction, a low-pressure dielectric barrier discharge ionization source, and a vacuumed headspace technique. Anal Chem. 2013;85(10):5033-9.
Kumano, S., Sugiyama, M., Yamada, M., Nishimura, K., Hasegawa, H., Morokuma, H., Inoue, H., & Hashimoto, Y. (2013). Development of a portable mass spectrometer characterized by discontinuous sample gas introduction, a low-pressure dielectric barrier discharge ionization source, and a vacuumed headspace technique. Analytical Chemistry, 85(10), 5033-9. https://doi.org/10.1021/ac4002904
Kumano S, et al. Development of a Portable Mass Spectrometer Characterized By Discontinuous Sample Gas Introduction, a Low-pressure Dielectric Barrier Discharge Ionization Source, and a Vacuumed Headspace Technique. Anal Chem. 2013 May 21;85(10):5033-9. PubMed PMID: 23577896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a portable mass spectrometer characterized by discontinuous sample gas introduction, a low-pressure dielectric barrier discharge ionization source, and a vacuumed headspace technique. AU - Kumano,Shun, AU - Sugiyama,Masuyuki, AU - Yamada,Masuyoshi, AU - Nishimura,Kazushige, AU - Hasegawa,Hideki, AU - Morokuma,Hidetoshi, AU - Inoue,Hiroyuki, AU - Hashimoto,Yuichiro, Y1 - 2013/05/07/ PY - 2013/4/13/entrez PY - 2013/4/13/pubmed PY - 2013/12/16/medline SP - 5033 EP - 9 JF - Analytical chemistry JO - Anal. Chem. VL - 85 IS - 10 N2 - The present study has attempted to downscale a mass spectrometer in order to make it portable and enable onsite analysis with it. The development of a small mass spectrometer required the use of a compact pump whose displacement was small, decreasing the sensitivity of that spectrometer. To get high sensitivity with a small mass spectrometer, we have integrated novel techniques: a highly sensitive ionization source and efficient extraction of sample vapor. The low-pressure dielectric barrier discharge ionization (LP-DBDI) source made it possible to increase the conductance between the source and the mass analyzer, compared with ambient ionization sources, enhancing the efficiency of the ion transfer from the ionization source to the mass analyzer. We have also developed a vacuumed headspace method efficiently transporting the sample vapor to the ionization source. The sensitivity was further enhanced by also using a discontinuous sample gas introduction technique. A prototype portable mass spectrometer using those novel techniques was found to be sensitive enough to detect 0.1 ppm methamphetamine, 1 ppm amphetamine, 1 ppm 3,4-methylenedioxymethamphetamine, and 10 ppm cocaine in liquid. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/23577896/Development_of_a_portable_mass_spectrometer_characterized_by_discontinuous_sample_gas_introduction_a_low_pressure_dielectric_barrier_discharge_ionization_source_and_a_vacuumed_headspace_technique_ L2 - https://dx.doi.org/10.1021/ac4002904 DB - PRIME DP - Unbound Medicine ER -