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Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors.
Clin Chem. 1990 Jun; 36(6):846-8.CC

Abstract

Iron-depleted donors are at increased risk of developing anemia; if these donors could be identified by a screening test, iron supplementation or decreased donation frequency could be considered. Tests to determine serum ferritin, blood hemoglobin, and erythrocyte (Erc)-zinc protoporphyrin concentrations were examined in 679 consecutive female blood donors to identify donors with non-anemic iron deficiency. The test to determine serum ferritin is expensive and slow, whereas the two latter tests are rapid and less costly and could therefore be used for screening. Women in the fertile age groups had the lowest average serum ferritin values. In all, 93 women (13.7%) had depleted iron stores, as indicated by serum ferritin concentrations less than 14 micrograms/L. In these women, a much better correlation was found between Erc-zinc protoporphyrin and serum ferritin (rs = -0.49, P less than 0.001) than between blood hemoglobin and serum ferritin (rs = 0.31, P less than 0.01). These findings suggest that measurement of Erc-zinc protoporphyrin is superior to that of blood hemoglobin in identifying donors with non-anemic iron deficiency.

Authors+Show Affiliations

Department of Environmental Medicine, Odense University, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2357820

Citation

Jensen, B M., et al. "Screening With Zinc Protoporphyrin for Iron Deficiency in Non-anemic Female Blood Donors." Clinical Chemistry, vol. 36, no. 6, 1990, pp. 846-8.
Jensen BM, Sandø SH, Grandjean P, et al. Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors. Clin Chem. 1990;36(6):846-8.
Jensen, B. M., Sandø, S. H., Grandjean, P., Wiggers, P., & Dalhøj, J. (1990). Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors. Clinical Chemistry, 36(6), 846-8.
Jensen BM, et al. Screening With Zinc Protoporphyrin for Iron Deficiency in Non-anemic Female Blood Donors. Clin Chem. 1990;36(6):846-8. PubMed PMID: 2357820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors. AU - Jensen,B M, AU - Sandø,S H, AU - Grandjean,P, AU - Wiggers,P, AU - Dalhøj,J, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 846 EP - 8 JF - Clinical chemistry JO - Clin Chem VL - 36 IS - 6 N2 - Iron-depleted donors are at increased risk of developing anemia; if these donors could be identified by a screening test, iron supplementation or decreased donation frequency could be considered. Tests to determine serum ferritin, blood hemoglobin, and erythrocyte (Erc)-zinc protoporphyrin concentrations were examined in 679 consecutive female blood donors to identify donors with non-anemic iron deficiency. The test to determine serum ferritin is expensive and slow, whereas the two latter tests are rapid and less costly and could therefore be used for screening. Women in the fertile age groups had the lowest average serum ferritin values. In all, 93 women (13.7%) had depleted iron stores, as indicated by serum ferritin concentrations less than 14 micrograms/L. In these women, a much better correlation was found between Erc-zinc protoporphyrin and serum ferritin (rs = -0.49, P less than 0.001) than between blood hemoglobin and serum ferritin (rs = 0.31, P less than 0.01). These findings suggest that measurement of Erc-zinc protoporphyrin is superior to that of blood hemoglobin in identifying donors with non-anemic iron deficiency. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/2357820/Screening_with_zinc_protoporphyrin_for_iron_deficiency_in_non_anemic_female_blood_donors_ DB - PRIME DP - Unbound Medicine ER -