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IgA subclass antibodies to gliadin in serum and intestinal juice of patients with coeliac disease.
Clin Exp Immunol. 1990 May; 80(2):192-5.CE

Abstract

Serum IgA anti-gliadin antibodies (AGA) were positive in 25 (68%) of 37 untreated adults with coeliac disease belonging mostly to IgA1 subclass (88%) and only in a few cases to IgA2 (12%). Antisecretory component IgA AGA were present in serum of seven patients (28%) by immunofluorescence and in nine (36%) by ELISA. The search for IgA AGA in jejunal juice of eight untreated children with coeliac disease was positive in seven cases (88%), with consistent finding of antisecretory component IgA AGA. These antibodies belonged with equal proportion to IgA1 and IgA2 subclasses. This study shows that in intestinal secretions of untreated coeliac disease cases the IgA immune response to gliadin is confined to polymeric anti-secretory component IgA with the same prevalence of IgA1 and IgA2 subclasses, while in serum IgA AGA are largely monomeric, more frequently of IgA1 than of IgA2 subclass, and with a lower proportion of polymeric anti-secretory component IgA (20-36%). The finding of secretory IgA AGA in serum of patients with coeliac disease could result from a spill-over from the intestinal mucosal synthesis into the circulation.

Authors+Show Affiliations

Istituto di Clinica Medica Generale e Terapia Medica, Cattedra di Semeiotica, Università di Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2357845

Citation

Volta, U, et al. "IgA Subclass Antibodies to Gliadin in Serum and Intestinal Juice of Patients With Coeliac Disease." Clinical and Experimental Immunology, vol. 80, no. 2, 1990, pp. 192-5.
Volta U, Molinaro N, Fratangelo D, et al. IgA subclass antibodies to gliadin in serum and intestinal juice of patients with coeliac disease. Clin Exp Immunol. 1990;80(2):192-5.
Volta, U., Molinaro, N., Fratangelo, D., & Bianchi, F. B. (1990). IgA subclass antibodies to gliadin in serum and intestinal juice of patients with coeliac disease. Clinical and Experimental Immunology, 80(2), 192-5.
Volta U, et al. IgA Subclass Antibodies to Gliadin in Serum and Intestinal Juice of Patients With Coeliac Disease. Clin Exp Immunol. 1990;80(2):192-5. PubMed PMID: 2357845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA subclass antibodies to gliadin in serum and intestinal juice of patients with coeliac disease. AU - Volta,U, AU - Molinaro,N, AU - Fratangelo,D, AU - Bianchi,F B, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 192 EP - 5 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 80 IS - 2 N2 - Serum IgA anti-gliadin antibodies (AGA) were positive in 25 (68%) of 37 untreated adults with coeliac disease belonging mostly to IgA1 subclass (88%) and only in a few cases to IgA2 (12%). Antisecretory component IgA AGA were present in serum of seven patients (28%) by immunofluorescence and in nine (36%) by ELISA. The search for IgA AGA in jejunal juice of eight untreated children with coeliac disease was positive in seven cases (88%), with consistent finding of antisecretory component IgA AGA. These antibodies belonged with equal proportion to IgA1 and IgA2 subclasses. This study shows that in intestinal secretions of untreated coeliac disease cases the IgA immune response to gliadin is confined to polymeric anti-secretory component IgA with the same prevalence of IgA1 and IgA2 subclasses, while in serum IgA AGA are largely monomeric, more frequently of IgA1 than of IgA2 subclass, and with a lower proportion of polymeric anti-secretory component IgA (20-36%). The finding of secretory IgA AGA in serum of patients with coeliac disease could result from a spill-over from the intestinal mucosal synthesis into the circulation. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/2357845/IgA_subclass_antibodies_to_gliadin_in_serum_and_intestinal_juice_of_patients_with_coeliac_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9104&date=1990&volume=80&issue=2&spage=192 DB - PRIME DP - Unbound Medicine ER -