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The effect of atropine and vagotomy on the secretion of gastric intrinsic factor (IF) in man.
Scand J Gastroenterol. 1975; 10(1):59-64.SJ

Abstract

The gastric secretion of IF, acid, and pepsin during basal conditions and stimulation by pentagastrin decreased significantly in 8 unoperated duodenal ulcer patients following administration of atropine. The basal concentrations of acid and pepsin decreased, whereas that of IF remained unchanged. An increase of plasma gastrin concentration from the basal value was observed after injection of atropine alone. The secretions of IF and acid decreased significantly from the pre-operative values after proximal gastric vagotomy in 7 duodenal ulcer patients. The basal IF output decreased by 19.8 per cent and the stimulated output by 41.4 per cent. The basal and stimulated secretions of acid decreased by 50.0 and 44.1 per cent, respectively. It is suggested that the smaller reduction of IF than of acid may be of importance for the vitamin B12 absorption after vagotomy. The decreased secretion of IF was secondary to the reduction of volume both after'medical' and surgical vagotomy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

235785

Citation

Vatn, M H., et al. "The Effect of Atropine and Vagotomy On the Secretion of Gastric Intrinsic Factor (IF) in Man." Scandinavian Journal of Gastroenterology, vol. 10, no. 1, 1975, pp. 59-64.
Vatn MH, Semb LS, Schrumpf E. The effect of atropine and vagotomy on the secretion of gastric intrinsic factor (IF) in man. Scand J Gastroenterol. 1975;10(1):59-64.
Vatn, M. H., Semb, L. S., & Schrumpf, E. (1975). The effect of atropine and vagotomy on the secretion of gastric intrinsic factor (IF) in man. Scandinavian Journal of Gastroenterology, 10(1), 59-64.
Vatn MH, Semb LS, Schrumpf E. The Effect of Atropine and Vagotomy On the Secretion of Gastric Intrinsic Factor (IF) in Man. Scand J Gastroenterol. 1975;10(1):59-64. PubMed PMID: 235785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of atropine and vagotomy on the secretion of gastric intrinsic factor (IF) in man. AU - Vatn,M H, AU - Semb,L S, AU - Schrumpf,E, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 59 EP - 64 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 10 IS - 1 N2 - The gastric secretion of IF, acid, and pepsin during basal conditions and stimulation by pentagastrin decreased significantly in 8 unoperated duodenal ulcer patients following administration of atropine. The basal concentrations of acid and pepsin decreased, whereas that of IF remained unchanged. An increase of plasma gastrin concentration from the basal value was observed after injection of atropine alone. The secretions of IF and acid decreased significantly from the pre-operative values after proximal gastric vagotomy in 7 duodenal ulcer patients. The basal IF output decreased by 19.8 per cent and the stimulated output by 41.4 per cent. The basal and stimulated secretions of acid decreased by 50.0 and 44.1 per cent, respectively. It is suggested that the smaller reduction of IF than of acid may be of importance for the vitamin B12 absorption after vagotomy. The decreased secretion of IF was secondary to the reduction of volume both after'medical' and surgical vagotomy. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/235785/The_effect_of_atropine_and_vagotomy_on_the_secretion_of_gastric_intrinsic_factor__IF__in_man_ DB - PRIME DP - Unbound Medicine ER -