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Intestinal microbiota and its role in irritable bowel syndrome (IBS).
Curr Gastroenterol Rep. 2013 May; 15(5):323.CG

Abstract

Gut microbiota alterations are increasingly being recognized as an important factor in the pathogenesis and pathophysiology of Irritable bowel syndrome (IBS). The onset of IBS symptoms after a bout of gastroenteritis comprises one of the strongest indications for the importance of gut microbiota for IBS. Moreover, recent studies have identified several susceptibility genes for IBS involved in the innate immunity and recognition of bacteria but also maintaining the integrity of the intestinal barrier. During recent years, it has also been demonstrated that IBS patients, or subgroups thereof, may have an altered microbiota composition relative to healthy individuals, mainly based on the analysis of fecal microbiota. Moreover, a positive effect of treatment with non-absorbable antibiotics and probiotics in IBS provides further indirect support for the relevance of gut microbiota alterations in IBS.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23580243

Citation

Ohman, Lena, and Magnus Simrén. "Intestinal Microbiota and Its Role in Irritable Bowel Syndrome (IBS)." Current Gastroenterology Reports, vol. 15, no. 5, 2013, p. 323.
Ohman L, Simrén M. Intestinal microbiota and its role in irritable bowel syndrome (IBS). Curr Gastroenterol Rep. 2013;15(5):323.
Ohman, L., & Simrén, M. (2013). Intestinal microbiota and its role in irritable bowel syndrome (IBS). Current Gastroenterology Reports, 15(5), 323. https://doi.org/10.1007/s11894-013-0323-7
Ohman L, Simrén M. Intestinal Microbiota and Its Role in Irritable Bowel Syndrome (IBS). Curr Gastroenterol Rep. 2013;15(5):323. PubMed PMID: 23580243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal microbiota and its role in irritable bowel syndrome (IBS). AU - Ohman,Lena, AU - Simrén,Magnus, PY - 2013/4/13/entrez PY - 2013/4/13/pubmed PY - 2013/9/21/medline SP - 323 EP - 323 JF - Current gastroenterology reports JO - Curr Gastroenterol Rep VL - 15 IS - 5 N2 - Gut microbiota alterations are increasingly being recognized as an important factor in the pathogenesis and pathophysiology of Irritable bowel syndrome (IBS). The onset of IBS symptoms after a bout of gastroenteritis comprises one of the strongest indications for the importance of gut microbiota for IBS. Moreover, recent studies have identified several susceptibility genes for IBS involved in the innate immunity and recognition of bacteria but also maintaining the integrity of the intestinal barrier. During recent years, it has also been demonstrated that IBS patients, or subgroups thereof, may have an altered microbiota composition relative to healthy individuals, mainly based on the analysis of fecal microbiota. Moreover, a positive effect of treatment with non-absorbable antibiotics and probiotics in IBS provides further indirect support for the relevance of gut microbiota alterations in IBS. SN - 1534-312X UR - https://www.unboundmedicine.com/medline/citation/23580243/Intestinal_microbiota_and_its_role_in_irritable_bowel_syndrome__IBS__ L2 - https://dx.doi.org/10.1007/s11894-013-0323-7 DB - PRIME DP - Unbound Medicine ER -