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Hydrogen sulfide signaling in the gastrointestinal tract.
Antioxid Redox Signal 2014; 20(5):818-30AR

Abstract

SIGNIFICANCE

The current literature regarding the effects of the gaseous signal molecule hydrogen sulfide (H2S) in the gastrointestinal system is reviewed. Bacterial, host and pharmaceutical-derived H2S are all considered and presented according to the physiological or pathophysiological effects of the gaseous signal molecule. These subjects include the toxicology of intestinal H2S with emphasis on bacterial-derived H2S, especially from sulfate-reducing bacteria, the role of endogenous and exogenous H2S in intestinal inflammation, and the roles of H2S in gastrointestinal motility, secretion and nociception.

RECENT ADVANCES

While its pro- and anti-inflammatory, smooth muscle relaxant, prosecretory, and pro- and antinociceptive actions continue to remain the major effects of H2S in this system; recent findings have expanded the potential molecular targets for H2S in the gastrointestinal tract.

CRITICAL ISSUES

Numerous discrepancies remain in the literature, and definitive molecular targets in this system have not been supported by the use of competitive antagonism.

FUTURE DIRECTIONS

Future work will hopefully resolve discrepancies in the literature and identify molecular targets and mechanisms of action for H2S. It is clear from the current literature that the long-appreciated relationship between H2S and the gastrointestinal tract continues to be strong as we endeavor to unravel its mysteries.

Authors+Show Affiliations

Enteric NeuroScience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine , Rochester, Minnesota.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

23582008

Citation

Linden, David R.. "Hydrogen Sulfide Signaling in the Gastrointestinal Tract." Antioxidants & Redox Signaling, vol. 20, no. 5, 2014, pp. 818-30.
Linden DR. Hydrogen sulfide signaling in the gastrointestinal tract. Antioxid Redox Signal. 2014;20(5):818-30.
Linden, D. R. (2014). Hydrogen sulfide signaling in the gastrointestinal tract. Antioxidants & Redox Signaling, 20(5), pp. 818-30. doi:10.1089/ars.2013.5312.
Linden DR. Hydrogen Sulfide Signaling in the Gastrointestinal Tract. Antioxid Redox Signal. 2014 Feb 10;20(5):818-30. PubMed PMID: 23582008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide signaling in the gastrointestinal tract. A1 - Linden,David R, Y1 - 2013/05/19/ PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2014/9/17/medline SP - 818 EP - 30 JF - Antioxidants & redox signaling JO - Antioxid. Redox Signal. VL - 20 IS - 5 N2 - SIGNIFICANCE: The current literature regarding the effects of the gaseous signal molecule hydrogen sulfide (H2S) in the gastrointestinal system is reviewed. Bacterial, host and pharmaceutical-derived H2S are all considered and presented according to the physiological or pathophysiological effects of the gaseous signal molecule. These subjects include the toxicology of intestinal H2S with emphasis on bacterial-derived H2S, especially from sulfate-reducing bacteria, the role of endogenous and exogenous H2S in intestinal inflammation, and the roles of H2S in gastrointestinal motility, secretion and nociception. RECENT ADVANCES: While its pro- and anti-inflammatory, smooth muscle relaxant, prosecretory, and pro- and antinociceptive actions continue to remain the major effects of H2S in this system; recent findings have expanded the potential molecular targets for H2S in the gastrointestinal tract. CRITICAL ISSUES: Numerous discrepancies remain in the literature, and definitive molecular targets in this system have not been supported by the use of competitive antagonism. FUTURE DIRECTIONS: Future work will hopefully resolve discrepancies in the literature and identify molecular targets and mechanisms of action for H2S. It is clear from the current literature that the long-appreciated relationship between H2S and the gastrointestinal tract continues to be strong as we endeavor to unravel its mysteries. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/23582008/Hydrogen_sulfide_signaling_in_the_gastrointestinal_tract_ L2 - https://www.liebertpub.com/doi/full/10.1089/ars.2013.5312?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -