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A review of numerical methods for red blood cell flow simulation.

Abstract

In this review, we provide an overview of the simulation techniques employed for modelling the flow of red blood cells (RBCs) in blood plasma. The scope of this review omits the fluid modelling aspect while focusing on other key components in the RBC-plasma model such as (1) describing the RBC deformation with shell-based and spring-based RBC models, (2) constitutive models for RBC aggregation based on bridging theory and depletion theory and (3) additional strategies required for completing the RBC-plasma flow model. These include topics such as modelling fluid-structure interaction with the immersed boundary method and boundary integral method, and updating the variations in multiphase fluid property through the employment of index field methods. Lastly, we summarily discuss the current state and aims of RBC modelling and suggest some research directions for the further development of this field of modelling.

Authors+Show Affiliations

a Department of Bioengineering , National University of Singapore , Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23582050

Citation

Ju, Meongkeun, et al. "A Review of Numerical Methods for Red Blood Cell Flow Simulation." Computer Methods in Biomechanics and Biomedical Engineering, vol. 18, no. 2, 2015, pp. 130-40.
Ju M, Ye SS, Namgung B, et al. A review of numerical methods for red blood cell flow simulation. Comput Methods Biomech Biomed Engin. 2015;18(2):130-40.
Ju, M., Ye, S. S., Namgung, B., Cho, S., Low, H. T., Leo, H. L., & Kim, S. (2015). A review of numerical methods for red blood cell flow simulation. Computer Methods in Biomechanics and Biomedical Engineering, 18(2), pp. 130-40. doi:10.1080/10255842.2013.783574.
Ju M, et al. A Review of Numerical Methods for Red Blood Cell Flow Simulation. Comput Methods Biomech Biomed Engin. 2015;18(2):130-40. PubMed PMID: 23582050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of numerical methods for red blood cell flow simulation. AU - Ju,Meongkeun, AU - Ye,Swe Soe, AU - Namgung,Bumseok, AU - Cho,Seungkwan, AU - Low,Hong Tong, AU - Leo,Hwa Liang, AU - Kim,Sangho, Y1 - 2013/04/14/ PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2015/12/29/medline KW - RBC aggregation modelling KW - RBC deformation modelling KW - blood rheology KW - haemodynamics SP - 130 EP - 40 JF - Computer methods in biomechanics and biomedical engineering JO - Comput Methods Biomech Biomed Engin VL - 18 IS - 2 N2 - In this review, we provide an overview of the simulation techniques employed for modelling the flow of red blood cells (RBCs) in blood plasma. The scope of this review omits the fluid modelling aspect while focusing on other key components in the RBC-plasma model such as (1) describing the RBC deformation with shell-based and spring-based RBC models, (2) constitutive models for RBC aggregation based on bridging theory and depletion theory and (3) additional strategies required for completing the RBC-plasma flow model. These include topics such as modelling fluid-structure interaction with the immersed boundary method and boundary integral method, and updating the variations in multiphase fluid property through the employment of index field methods. Lastly, we summarily discuss the current state and aims of RBC modelling and suggest some research directions for the further development of this field of modelling. SN - 1476-8259 UR - https://www.unboundmedicine.com/medline/citation/23582050/A_review_of_numerical_methods_for_red_blood_cell_flow_simulation_ L2 - http://www.tandfonline.com/doi/full/10.1080/10255842.2013.783574 DB - PRIME DP - Unbound Medicine ER -