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[Effectiveness of influenza vaccination in preventing hospital admission due to exacerbations of chronic obstructive pulmonary disease].
Enferm Infecc Microbiol Clin 2014; 32(2):70-5EI

Abstract

INTRODUCTION

The main objective was to determine the effectiveness of influenza vaccination in preventing hospitalization due to exacerbation of chronic obstructive pulmonary disease (COPD). One secondary objective was to estimate the prevalence of vaccination, and to describe the factors that were associated with being vaccinated.

METHODS

A retrospective cohort study was conducted that included 1,323 patients diagnosed with COPD in the Health Centre of the Pla d'Urgell (Lleida, Spain). They were classified into two cohorts: cohort1, patients vaccinated against seasonal influenza (campaign 2011/12), and cohort2, non-vaccinated. The number of patients in both cohorts requiring hospital admission for exacerbation of the disease between the 12/01/2011 and the 03/15/2012 was quantified. Information about the variables of interest was recorded for each patient. A univariate and multivariate analysis was performed. The effectiveness of vaccination was calculated with the formula: E=(1-OR)×100. The ORs and their 95% confidence interval (95%CI) were determined by multivariate logistic regression models.

RESULTS

Just over half (55.3%) of the patients had been vaccinated. Vaccinated patients were older and had more associated comorbidity. At the same time, they were less hospitalized (3.0% versus 8.9%; P=.001). The crude and adjusted effectiveness of influenza vaccination in this population subgroup was 68.4% (95%CI: 47.5-81.0) and 90.8 (95%CI: 96.8-88.2), respectively.

CONCLUSION

Influenza vaccination is effective in preventing hospitalization due to acute exacerbations in COPD patients. However, immunization coverage is not as high as desired. Designing programs to increase the rate of vaccination in this population would reduce the number of hospital admissions for COPD exacerbation.

Authors+Show Affiliations

Área Básica de Salud del Pla d'Urgell, CAP Mollerussa, Institut Català de la Salut, Mollerussa, Lleida, España. Electronic address: jmontser@alumni.unav.es.Institut de Recerca Biomèdica de Lleida, Facultad de Medicina, Universidad de Lleida, CIBER de Epidemiología y Salud Pública, Lleida, España.Unitat de Suport a la Recerca Lleida-Pirineus, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Institut Català de la Salut, Lleida, España; Unidad de Epidemiología, Servicio de Cardiología, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, España.Unitat de Suport a la Recerca Lleida-Pirineus, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Institut Català de la Salut, Lleida, España.Dirección del Servicio de Atención Primaria, Institut Català de la Salut, Lleida, España.

Pub Type(s)

Evaluation Studies
Journal Article

Language

spa

PubMed ID

23582192

Citation

Montserrat-Capdevila, Josep, et al. "[Effectiveness of Influenza Vaccination in Preventing Hospital Admission Due to Exacerbations of Chronic Obstructive Pulmonary Disease]." Enfermedades Infecciosas Y Microbiologia Clinica, vol. 32, no. 2, 2014, pp. 70-5.
Montserrat-Capdevila J, Godoy P, Marsal JR, et al. [Effectiveness of influenza vaccination in preventing hospital admission due to exacerbations of chronic obstructive pulmonary disease]. Enferm Infecc Microbiol Clin. 2014;32(2):70-5.
Montserrat-Capdevila, J., Godoy, P., Marsal, J. R., Cruz, I., & Solanes, M. (2014). [Effectiveness of influenza vaccination in preventing hospital admission due to exacerbations of chronic obstructive pulmonary disease]. Enfermedades Infecciosas Y Microbiologia Clinica, 32(2), pp. 70-5. doi:10.1016/j.eimc.2013.02.009.
Montserrat-Capdevila J, et al. [Effectiveness of Influenza Vaccination in Preventing Hospital Admission Due to Exacerbations of Chronic Obstructive Pulmonary Disease]. Enferm Infecc Microbiol Clin. 2014;32(2):70-5. PubMed PMID: 23582192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effectiveness of influenza vaccination in preventing hospital admission due to exacerbations of chronic obstructive pulmonary disease]. AU - Montserrat-Capdevila,Josep, AU - Godoy,Pere, AU - Marsal,Josep-Ramon, AU - Cruz,Inés, AU - Solanes,Mònica, Y1 - 2013/04/11/ PY - 2012/12/02/received PY - 2013/02/14/revised PY - 2013/02/17/accepted PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2015/4/14/medline KW - Chronic obstructive pulmonary disease KW - Enfermedad pulmonar obstructiva crónica KW - Influenza vaccines KW - Prevención primaria KW - Primary prevention KW - Vacunación antigripal SP - 70 EP - 5 JF - Enfermedades infecciosas y microbiologia clinica JO - Enferm. Infecc. Microbiol. Clin. VL - 32 IS - 2 N2 - INTRODUCTION: The main objective was to determine the effectiveness of influenza vaccination in preventing hospitalization due to exacerbation of chronic obstructive pulmonary disease (COPD). One secondary objective was to estimate the prevalence of vaccination, and to describe the factors that were associated with being vaccinated. METHODS: A retrospective cohort study was conducted that included 1,323 patients diagnosed with COPD in the Health Centre of the Pla d'Urgell (Lleida, Spain). They were classified into two cohorts: cohort1, patients vaccinated against seasonal influenza (campaign 2011/12), and cohort2, non-vaccinated. The number of patients in both cohorts requiring hospital admission for exacerbation of the disease between the 12/01/2011 and the 03/15/2012 was quantified. Information about the variables of interest was recorded for each patient. A univariate and multivariate analysis was performed. The effectiveness of vaccination was calculated with the formula: E=(1-OR)×100. The ORs and their 95% confidence interval (95%CI) were determined by multivariate logistic regression models. RESULTS: Just over half (55.3%) of the patients had been vaccinated. Vaccinated patients were older and had more associated comorbidity. At the same time, they were less hospitalized (3.0% versus 8.9%; P=.001). The crude and adjusted effectiveness of influenza vaccination in this population subgroup was 68.4% (95%CI: 47.5-81.0) and 90.8 (95%CI: 96.8-88.2), respectively. CONCLUSION: Influenza vaccination is effective in preventing hospitalization due to acute exacerbations in COPD patients. However, immunization coverage is not as high as desired. Designing programs to increase the rate of vaccination in this population would reduce the number of hospital admissions for COPD exacerbation. SN - 1578-1852 UR - https://www.unboundmedicine.com/medline/citation/23582192/[Effectiveness_of_influenza_vaccination_in_preventing_hospital_admission_due_to_exacerbations_of_chronic_obstructive_pulmonary_disease]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0213-005X(13)00054-2 DB - PRIME DP - Unbound Medicine ER -