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Weight change at 12 months in users of three progestin-only contraceptive methods.
Contraception 2013; 88(4):503-8C

Abstract

BACKGROUND

Concerns about weight gain may influence contraceptive use. We compared the change in body weight over the first 12 months of use between women using the etonogestrel (ENG) implant, the levonorgestrel intrauterine system (LNG-IUS) or depot medroxyprogesterone acetate (DMPA) with women using the copper intrauterine device (IUD).

STUDY DESIGN

This was a substudy of the Contraceptive CHOICE Project, a prospective cohort study of 9256 women provided no-cost contraception. Women who had been using the ENG implant, LNG-IUS, DMPA or copper IUD continuously for at least 11 months were eligible for participation. We obtained body weight at enrollment and at 12 months and compared the weight change for each progestin-only method to the copper IUD.

RESULTS

We enrolled a total of 427 women: 130 ENG implant users, 130 LNG-IUS users, 67 DMPA users and 100 copper IUD users. The mean weight change (in kilograms) over 12 months was 2.1 for ENG implant users [standard deviation (SD)=6.7]; 1.0 for LNG-IUS users (SD=5.3); 2.2 for DMPA users (SD=4.9) and 0.2 for copper IUD users (SD=5.1). The range of weight change was broad across all contraceptive methods. In the unadjusted linear regression model, ENG implant and DMPA use were associated with weight gain compared to the copper IUD. However, in the adjusted model, no difference in weight gain with the ENG implant, LNG-IUS or DMPA was observed. Only Black race was associated with significant weight gain (1.3 kg, 95% confidence interval=0.2-2.4) when compared to other racial groups.

CONCLUSIONS

Weight change was variable among women using progestin-only contraceptives. Black race was a significant predictor of weight gain among contraceptive users.

Authors+Show Affiliations

Riverbend Medical Group, Agawam, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23582238

Citation

Vickery, Zevidah, et al. "Weight Change at 12 Months in Users of Three Progestin-only Contraceptive Methods." Contraception, vol. 88, no. 4, 2013, pp. 503-8.
Vickery Z, Madden T, Zhao Q, et al. Weight change at 12 months in users of three progestin-only contraceptive methods. Contraception. 2013;88(4):503-8.
Vickery, Z., Madden, T., Zhao, Q., Secura, G. M., Allsworth, J. E., & Peipert, J. F. (2013). Weight change at 12 months in users of three progestin-only contraceptive methods. Contraception, 88(4), pp. 503-8. doi:10.1016/j.contraception.2013.03.004.
Vickery Z, et al. Weight Change at 12 Months in Users of Three Progestin-only Contraceptive Methods. Contraception. 2013;88(4):503-8. PubMed PMID: 23582238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight change at 12 months in users of three progestin-only contraceptive methods. AU - Vickery,Zevidah, AU - Madden,Tessa, AU - Zhao,Qiuhong, AU - Secura,Gina M, AU - Allsworth,Jenifer E, AU - Peipert,Jeffrey F, Y1 - 2013/03/18/ PY - 2012/11/12/received PY - 2013/03/06/revised PY - 2013/03/11/accepted PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2014/4/18/medline KW - Contraception KW - Copper intrauterine device KW - Etonogestrel implant KW - Levonorgestrel intrauterine system KW - Weight change SP - 503 EP - 8 JF - Contraception JO - Contraception VL - 88 IS - 4 N2 - BACKGROUND: Concerns about weight gain may influence contraceptive use. We compared the change in body weight over the first 12 months of use between women using the etonogestrel (ENG) implant, the levonorgestrel intrauterine system (LNG-IUS) or depot medroxyprogesterone acetate (DMPA) with women using the copper intrauterine device (IUD). STUDY DESIGN: This was a substudy of the Contraceptive CHOICE Project, a prospective cohort study of 9256 women provided no-cost contraception. Women who had been using the ENG implant, LNG-IUS, DMPA or copper IUD continuously for at least 11 months were eligible for participation. We obtained body weight at enrollment and at 12 months and compared the weight change for each progestin-only method to the copper IUD. RESULTS: We enrolled a total of 427 women: 130 ENG implant users, 130 LNG-IUS users, 67 DMPA users and 100 copper IUD users. The mean weight change (in kilograms) over 12 months was 2.1 for ENG implant users [standard deviation (SD)=6.7]; 1.0 for LNG-IUS users (SD=5.3); 2.2 for DMPA users (SD=4.9) and 0.2 for copper IUD users (SD=5.1). The range of weight change was broad across all contraceptive methods. In the unadjusted linear regression model, ENG implant and DMPA use were associated with weight gain compared to the copper IUD. However, in the adjusted model, no difference in weight gain with the ENG implant, LNG-IUS or DMPA was observed. Only Black race was associated with significant weight gain (1.3 kg, 95% confidence interval=0.2-2.4) when compared to other racial groups. CONCLUSIONS: Weight change was variable among women using progestin-only contraceptives. Black race was a significant predictor of weight gain among contraceptive users. SN - 1879-0518 UR - https://www.unboundmedicine.com/medline/citation/23582238/Weight_change_at_12_months_in_users_of_three_progestin_only_contraceptive_methods_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(13)00090-5 DB - PRIME DP - Unbound Medicine ER -