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Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer.

Abstract

AIM

Obesity is an established risk factor for endometrial cancer. Associations tend to be stronger for the endometrioid subtype. The role of adult weight change and weight cycling is uncertain. Our study aimed to determine whether there is an association between different adult weight trajectories, weight cycling and risk of endometrial cancer overall, and by subtype.

METHODS

We analysed data from the Australian National Endometrial Cancer study, a population-based case-control study that collected self-reported information on height, weight at three time points (age 20, maximum and 1 year prior to diagnosis [recent]), intentional weight loss/regain (weight cycling) from 1398 women with endometrial cancer and 1538 controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression analysis.

RESULTS

Relative to women who maintained a stable weight during adulthood, greater weight gain after the age of 20 was associated with increased risk of endometrial cancer (OR for gain 40+kg all subtypes 5.3, 95% CI 3.9-7.3; endometrioid 6.5, 95% CI 4.7-9.0). The strongest associations were observed among women who were continually overweight from the age of 20 (all subtypes OR 3.6, 95% CI 2.6-5.0). Weight cycling was associated with increased risk, particularly among women who had ever been obese (OR 2.9 95% CI 1.8-4.7), with ~3-fold risks seen for both endometrioid and non-endometrioid tumour subtypes. Women who had intentionally lost weight and maintained that weight loss were not at increased risk.

CONCLUSION

These results suggest that higher adult weight gain, and perhaps weight cycling, independently increase the risk of endometrial cancer, however women who lost weight and kept that weight off were not at increased risk.

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  • Authors+Show Affiliations

    ,

    Population Health Department, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia. Christina.Nagle@qimr.edu.au

    , , , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Australia
    Body Mass Index
    Body Weight
    Case-Control Studies
    Comorbidity
    Endometrial Neoplasms
    Female
    Humans
    Logistic Models
    Middle Aged
    Multivariate Analysis
    Obesity
    Risk Assessment
    Risk Factors
    Weight Gain
    Weight Loss
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23583438

    Citation

    Nagle, C M., et al. "Impact of Weight Change and Weight Cycling On Risk of Different Subtypes of Endometrial Cancer." European Journal of Cancer (Oxford, England : 1990), vol. 49, no. 12, 2013, pp. 2717-26.
    Nagle CM, Marquart L, Bain CJ, et al. Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer. Eur J Cancer. 2013;49(12):2717-26.
    Nagle, C. M., Marquart, L., Bain, C. J., O'Brien, S., Lahmann, P. H., Quinn, M., ... Webb, P. M. (2013). Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer. European Journal of Cancer (Oxford, England : 1990), 49(12), pp. 2717-26. doi:10.1016/j.ejca.2013.03.015.
    Nagle CM, et al. Impact of Weight Change and Weight Cycling On Risk of Different Subtypes of Endometrial Cancer. Eur J Cancer. 2013;49(12):2717-26. PubMed PMID: 23583438.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer. AU - Nagle,C M, AU - Marquart,L, AU - Bain,C J, AU - O'Brien,S, AU - Lahmann,P H, AU - Quinn,M, AU - Oehler,M K, AU - Obermair,A, AU - Spurdle,A B, AU - Webb,P M, AU - ,, Y1 - 2013/04/11/ PY - 2012/11/22/received PY - 2013/03/05/revised PY - 2013/03/07/accepted PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2013/9/17/medline KW - Body mass index KW - Endometrial cancer KW - Histologic subtype KW - Obesity KW - Weight change KW - Weight cycling SP - 2717 EP - 26 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 49 IS - 12 N2 - AIM: Obesity is an established risk factor for endometrial cancer. Associations tend to be stronger for the endometrioid subtype. The role of adult weight change and weight cycling is uncertain. Our study aimed to determine whether there is an association between different adult weight trajectories, weight cycling and risk of endometrial cancer overall, and by subtype. METHODS: We analysed data from the Australian National Endometrial Cancer study, a population-based case-control study that collected self-reported information on height, weight at three time points (age 20, maximum and 1 year prior to diagnosis [recent]), intentional weight loss/regain (weight cycling) from 1398 women with endometrial cancer and 1538 controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression analysis. RESULTS: Relative to women who maintained a stable weight during adulthood, greater weight gain after the age of 20 was associated with increased risk of endometrial cancer (OR for gain 40+kg all subtypes 5.3, 95% CI 3.9-7.3; endometrioid 6.5, 95% CI 4.7-9.0). The strongest associations were observed among women who were continually overweight from the age of 20 (all subtypes OR 3.6, 95% CI 2.6-5.0). Weight cycling was associated with increased risk, particularly among women who had ever been obese (OR 2.9 95% CI 1.8-4.7), with ~3-fold risks seen for both endometrioid and non-endometrioid tumour subtypes. Women who had intentionally lost weight and maintained that weight loss were not at increased risk. CONCLUSION: These results suggest that higher adult weight gain, and perhaps weight cycling, independently increase the risk of endometrial cancer, however women who lost weight and kept that weight off were not at increased risk. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/23583438/Impact_of_weight_change_and_weight_cycling_on_risk_of_different_subtypes_of_endometrial_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(13)00218-9 DB - PRIME DP - Unbound Medicine ER -