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Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin.
Obesity (Silver Spring). 2013 Jul; 21(7):1467-73.O

Abstract

OBJECTIVE

Previous epidemiological studies together with animal studies have suggested an association between adiponectin and oxidative stress and inflammation, but community-based studies are lacking. Our objective was to investigate the relative importance of oxidative stress and inflammatory markers, representing different pathways in relation to adiponectin.

DESIGN AND METHODS

In a cross-sectional sample of 929 70-year-old individuals (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors study, relations between serum adiponectin and oxidative stress [conjugated dienes (CD), homocysteine, total antioxidant capacity, oxidized low-density lipoprotein (OxLDL), OxLDL antibodies, baseline CD of LDL, glutathione (GSH), total glutathione (TGSH), glutathione disulfide], circulation interleukins (IL-6, IL-8), other cytokines [tumor necrosis factor α, monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor], cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, P-selectin, L-selectin), and systemic inflammatory markers [C-reactive protein (CRP), leukocyte count] in separate models were investigated.

RESULTS

In age- and sex-adjusted, as well as multivariable-adjusted models, adiponectin was significantly and positively associated with GSH, log TGSH, whereas an inverse association was observed for CD and log EGF. An inverse association between adiponectin and MCP-1, log E-selectin, and log CRP was significant in age- and sex-adjusted models, but not in multivariable-adjusted models.

CONCLUSIONS

Our results imply that higher levels of adiponectin are associated with a more beneficial oxidative stress profile, with higher levels of principal anti-oxidative GSH and total GSH together with lower levels of lipid peroxidation, possibly through shared pathways. Further studies are needed to investigate whether changes in the oxidative stress profile may be a mechanism linking adiponectin with type 2 diabetes and/or cardiovascular disease.

Authors+Show Affiliations

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. stefan.gustafsson@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23585283

Citation

Gustafsson, Stefan, et al. "Oxidative Stress and Inflammatory Markers in Relation to Circulating Levels of Adiponectin." Obesity (Silver Spring, Md.), vol. 21, no. 7, 2013, pp. 1467-73.
Gustafsson S, Lind L, Söderberg S, et al. Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin. Obesity (Silver Spring). 2013;21(7):1467-73.
Gustafsson, S., Lind, L., Söderberg, S., Zilmer, M., Hulthe, J., & Ingelsson, E. (2013). Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin. Obesity (Silver Spring, Md.), 21(7), 1467-73. https://doi.org/10.1002/oby.20097
Gustafsson S, et al. Oxidative Stress and Inflammatory Markers in Relation to Circulating Levels of Adiponectin. Obesity (Silver Spring). 2013;21(7):1467-73. PubMed PMID: 23585283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin. AU - Gustafsson,Stefan, AU - Lind,Lars, AU - Söderberg,Stefan, AU - Zilmer,Mihkel, AU - Hulthe,Johannes, AU - Ingelsson,Erik, Y1 - 2013/04/13/ PY - 2012/04/12/received PY - 2012/08/29/accepted PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2014/3/4/medline SP - 1467 EP - 73 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 21 IS - 7 N2 - OBJECTIVE: Previous epidemiological studies together with animal studies have suggested an association between adiponectin and oxidative stress and inflammation, but community-based studies are lacking. Our objective was to investigate the relative importance of oxidative stress and inflammatory markers, representing different pathways in relation to adiponectin. DESIGN AND METHODS: In a cross-sectional sample of 929 70-year-old individuals (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors study, relations between serum adiponectin and oxidative stress [conjugated dienes (CD), homocysteine, total antioxidant capacity, oxidized low-density lipoprotein (OxLDL), OxLDL antibodies, baseline CD of LDL, glutathione (GSH), total glutathione (TGSH), glutathione disulfide], circulation interleukins (IL-6, IL-8), other cytokines [tumor necrosis factor α, monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor], cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, P-selectin, L-selectin), and systemic inflammatory markers [C-reactive protein (CRP), leukocyte count] in separate models were investigated. RESULTS: In age- and sex-adjusted, as well as multivariable-adjusted models, adiponectin was significantly and positively associated with GSH, log TGSH, whereas an inverse association was observed for CD and log EGF. An inverse association between adiponectin and MCP-1, log E-selectin, and log CRP was significant in age- and sex-adjusted models, but not in multivariable-adjusted models. CONCLUSIONS: Our results imply that higher levels of adiponectin are associated with a more beneficial oxidative stress profile, with higher levels of principal anti-oxidative GSH and total GSH together with lower levels of lipid peroxidation, possibly through shared pathways. Further studies are needed to investigate whether changes in the oxidative stress profile may be a mechanism linking adiponectin with type 2 diabetes and/or cardiovascular disease. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/23585283/Oxidative_stress_and_inflammatory_markers_in_relation_to_circulating_levels_of_adiponectin_ L2 - https://doi.org/10.1002/oby.20097 DB - PRIME DP - Unbound Medicine ER -