Tags

Type your tag names separated by a space and hit enter

Vitamin D deficiency in children with a chronic illness-seasonal and age-related variations in serum 25-hydroxy Vitamin D concentrations.
PLoS One. 2013; 8(4):e60856.Plos

Abstract

INTRODUCTION

Children and adolescents with a chronic illness have potential risk factors for vitamin D deficiency. An optimal vitamin D status might have multiple health effects. This study evaluated vitamin D status and its association with age, gender, and season in a large cohort of chronically ill Finnish patients at a tertiary pediatric outpatient clinic. A cross-sectional register-based study was carried out, involving altogether 1351 children (51% boys, age range 0.2-18 years), who visited the outpatient clinic during 2007-2010 and had their vitamin D status (S-25-OHD) determined. A post-doc analysis was conducted to identify predisposing and preventing factors for vitamin D deficiency.

RESULTS

Almost half (47%) of the S-25-OHD values were consistent with subnormal vitamin D status (S-25-OHD <50 nmol/L) while only 12% were >80 nmol/L. Age and season were the most important determinants for S-25-OHD concentration. Mean S-25-OHD concentration differed between age groups (Kruskal-Wallis; p<0.001), adolescents being at highest risk for vitamin D insufficiency. Young age and vitamin D supplementation were preventive factors for deficiency, while non-Finnish ethnic background was a predisposing factor. S-25-OHD showed significant seasonal variation in children older than 6 years. In the whole cohort, S-25-OHD was on average 13 nmol/L higher in summer than in winter, and the prevalence of vitamin D deficiency (= S-25-OHD <37.5 nmol/l) varied from 11% in summer to 29% in winter.

CONCLUSIONS

The finding that almost half of the studied Finnish children with a chronic illness had suboptimal vitamin D status is alarming. Inferior vitamin D status was noted in adolescents compared with younger children, suggesting that imbalance between intake and requirement evolves with age. Although less common during summer, subnormal vitamin D status was still observed in 28% of those evaluated in summer. Clinicians should identify individuals at risk and actively recommend vitamin D supplementation.

Authors+Show Affiliations

Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23585857

Citation

Holmlund-Suila, Elisa, et al. "Vitamin D Deficiency in Children With a Chronic Illness-seasonal and Age-related Variations in Serum 25-hydroxy Vitamin D Concentrations." PloS One, vol. 8, no. 4, 2013, pp. e60856.
Holmlund-Suila E, Koskivirta P, Metso T, et al. Vitamin D deficiency in children with a chronic illness-seasonal and age-related variations in serum 25-hydroxy Vitamin D concentrations. PLoS ONE. 2013;8(4):e60856.
Holmlund-Suila, E., Koskivirta, P., Metso, T., Andersson, S., Mäkitie, O., & Viljakainen, H. T. (2013). Vitamin D deficiency in children with a chronic illness-seasonal and age-related variations in serum 25-hydroxy Vitamin D concentrations. PloS One, 8(4), e60856. https://doi.org/10.1371/journal.pone.0060856
Holmlund-Suila E, et al. Vitamin D Deficiency in Children With a Chronic Illness-seasonal and Age-related Variations in Serum 25-hydroxy Vitamin D Concentrations. PLoS ONE. 2013;8(4):e60856. PubMed PMID: 23585857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency in children with a chronic illness-seasonal and age-related variations in serum 25-hydroxy Vitamin D concentrations. AU - Holmlund-Suila,Elisa, AU - Koskivirta,Panu, AU - Metso,Tuula, AU - Andersson,Sture, AU - Mäkitie,Outi, AU - Viljakainen,Heli T, Y1 - 2013/04/09/ PY - 2012/07/18/received PY - 2013/03/04/accepted PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2013/10/23/medline SP - e60856 EP - e60856 JF - PloS one JO - PLoS ONE VL - 8 IS - 4 N2 - INTRODUCTION: Children and adolescents with a chronic illness have potential risk factors for vitamin D deficiency. An optimal vitamin D status might have multiple health effects. This study evaluated vitamin D status and its association with age, gender, and season in a large cohort of chronically ill Finnish patients at a tertiary pediatric outpatient clinic. A cross-sectional register-based study was carried out, involving altogether 1351 children (51% boys, age range 0.2-18 years), who visited the outpatient clinic during 2007-2010 and had their vitamin D status (S-25-OHD) determined. A post-doc analysis was conducted to identify predisposing and preventing factors for vitamin D deficiency. RESULTS: Almost half (47%) of the S-25-OHD values were consistent with subnormal vitamin D status (S-25-OHD <50 nmol/L) while only 12% were >80 nmol/L. Age and season were the most important determinants for S-25-OHD concentration. Mean S-25-OHD concentration differed between age groups (Kruskal-Wallis; p<0.001), adolescents being at highest risk for vitamin D insufficiency. Young age and vitamin D supplementation were preventive factors for deficiency, while non-Finnish ethnic background was a predisposing factor. S-25-OHD showed significant seasonal variation in children older than 6 years. In the whole cohort, S-25-OHD was on average 13 nmol/L higher in summer than in winter, and the prevalence of vitamin D deficiency (= S-25-OHD <37.5 nmol/l) varied from 11% in summer to 29% in winter. CONCLUSIONS: The finding that almost half of the studied Finnish children with a chronic illness had suboptimal vitamin D status is alarming. Inferior vitamin D status was noted in adolescents compared with younger children, suggesting that imbalance between intake and requirement evolves with age. Although less common during summer, subnormal vitamin D status was still observed in 28% of those evaluated in summer. Clinicians should identify individuals at risk and actively recommend vitamin D supplementation. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23585857/Vitamin_D_deficiency_in_children_with_a_chronic_illness_seasonal_and_age_related_variations_in_serum_25_hydroxy_Vitamin_D_concentrations_ L2 - http://dx.plos.org/10.1371/journal.pone.0060856 DB - PRIME DP - Unbound Medicine ER -