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Effects of lawsone methyl ether mouthwash on oral Candida in HIV-infected subjects and subjects with denture stomatitis.
J Oral Pathol Med. 2013 Oct; 42(9):698-704.JO

Abstract

OBJECTIVES

To determine (i) effects of lawsone methyl ether (LME) mouthwash on antifungal drug resistance of oral Candida, (ii) effects of LME mouthwash on changes in genotype of oral Candida, and (iii) allergy and subjects' satisfaction on LME mouthwash in comparison with chlorhexidine (CHX).

MATERIALS AND METHODS

A randomized clinical trial was conducted in HIV-infected subjects and denture wearers receiving either LME or CHX mouthwash. Candidal culture by oral rinse technique was performed as baseline and after using the mouthwash for 2 weeks. Antifungal drug resistance and changes in genotype of oral Candida were assessed by microdilution assay, inverted repeat polymerase chain reaction and restriction fragment length polymorphism assays, respectively. Allergy and subjects' satisfaction on the mouthwashes were recorded. Statistical analysis was performed using Chi-squared and Fisher's exact tests.

RESULTS

Twenty-nine HIV-infected subjects (age range, 26-54 years; mean age, 41 years) and 38 denture wearers (age range, 27-76 years; mean age, 55 years) were enrolled. C. albicans was the most common specie found in both groups followed by C. tropicalis, C. parapsilosis, and C. glabrata. Neither antifungal drug resistance nor significant changes in genotyping of Candida were noted among those receiving LME mouthwash. Subjects' satisfaction on taste and smell of LME mouthwash was comparable to that of CHX.

CONCLUSIONS

Use of LME mouthwash for 2 weeks neither led to antifungal drug resistance nor significant changes in genotype of oral Candida. Thus, LME may be an alternative mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease.

Authors+Show Affiliations

Prince of Songkla University, Hat Yai, Songkhla, Thailand; Phytomedicine and Pharmaceutical Biotechnology Research Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand; Natural Product Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23586936

Citation

Nittayananta, Wipawee, et al. "Effects of Lawsone Methyl Ether Mouthwash On Oral Candida in HIV-infected Subjects and Subjects With Denture Stomatitis." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 42, no. 9, 2013, pp. 698-704.
Nittayananta W, Pangsomboon K, Panichayupakaranant P, et al. Effects of lawsone methyl ether mouthwash on oral Candida in HIV-infected subjects and subjects with denture stomatitis. J Oral Pathol Med. 2013;42(9):698-704.
Nittayananta, W., Pangsomboon, K., Panichayupakaranant, P., Chanowanna, N., Chelae, S., Vuddhakul, V., Sukhumungoon, P., & Pruphetkaew, N. (2013). Effects of lawsone methyl ether mouthwash on oral Candida in HIV-infected subjects and subjects with denture stomatitis. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 42(9), 698-704. https://doi.org/10.1111/jop.12060
Nittayananta W, et al. Effects of Lawsone Methyl Ether Mouthwash On Oral Candida in HIV-infected Subjects and Subjects With Denture Stomatitis. J Oral Pathol Med. 2013;42(9):698-704. PubMed PMID: 23586936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of lawsone methyl ether mouthwash on oral Candida in HIV-infected subjects and subjects with denture stomatitis. AU - Nittayananta,Wipawee, AU - Pangsomboon,Kanokporn, AU - Panichayupakaranant,Pharkphoom, AU - Chanowanna,Nilnara, AU - Chelae,Sureerat, AU - Vuddhakul,Varaporn, AU - Sukhumungoon,Pharanai, AU - Pruphetkaew,Nannapat, Y1 - 2013/04/16/ PY - 2013/02/28/accepted PY - 2013/4/17/entrez PY - 2013/4/17/pubmed PY - 2014/8/30/medline KW - Candida KW - HIV KW - antifungal activity KW - antifungal drug resistance KW - chlorhexidine KW - genotyping KW - lawsone methyl ether KW - mouthwash SP - 698 EP - 704 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 42 IS - 9 N2 - OBJECTIVES: To determine (i) effects of lawsone methyl ether (LME) mouthwash on antifungal drug resistance of oral Candida, (ii) effects of LME mouthwash on changes in genotype of oral Candida, and (iii) allergy and subjects' satisfaction on LME mouthwash in comparison with chlorhexidine (CHX). MATERIALS AND METHODS: A randomized clinical trial was conducted in HIV-infected subjects and denture wearers receiving either LME or CHX mouthwash. Candidal culture by oral rinse technique was performed as baseline and after using the mouthwash for 2 weeks. Antifungal drug resistance and changes in genotype of oral Candida were assessed by microdilution assay, inverted repeat polymerase chain reaction and restriction fragment length polymorphism assays, respectively. Allergy and subjects' satisfaction on the mouthwashes were recorded. Statistical analysis was performed using Chi-squared and Fisher's exact tests. RESULTS: Twenty-nine HIV-infected subjects (age range, 26-54 years; mean age, 41 years) and 38 denture wearers (age range, 27-76 years; mean age, 55 years) were enrolled. C. albicans was the most common specie found in both groups followed by C. tropicalis, C. parapsilosis, and C. glabrata. Neither antifungal drug resistance nor significant changes in genotyping of Candida were noted among those receiving LME mouthwash. Subjects' satisfaction on taste and smell of LME mouthwash was comparable to that of CHX. CONCLUSIONS: Use of LME mouthwash for 2 weeks neither led to antifungal drug resistance nor significant changes in genotype of oral Candida. Thus, LME may be an alternative mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/23586936/Effects_of_lawsone_methyl_ether_mouthwash_on_oral_Candida_in_HIV_infected_subjects_and_subjects_with_denture_stomatitis_ L2 - https://doi.org/10.1111/jop.12060 DB - PRIME DP - Unbound Medicine ER -