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The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease.
BMC Immunol. 2013 Apr 15; 14:19.BI

Abstract

BACKGROUND

Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subclasses on renal tissue is still unclear. In the current study, we investigated the deposition of the four IgG subclasses using immunohistochemistry in the renal biopsy specimens from 46 patients with anti-GBM disease.

RESULTS

All four IgG subclasses can be detected within the GBM. Anti-GBM IgG3 was detected in all patients (100%), with 39 (84.8%) patients presenting with weak segmental staining and 7 (15.2%) patients with strong linear deposition. Anti-GBM IgG2 was detected in 22 (47.8%) patients, with 20 (90.9%) patients having weak segmental deposition and 2 (9.1%) patients presenting strong linear staining. Anti-GBM IgG1 and IgG4 were detected in 9 (19.6%) and 7 (15.2%) patients, respectively. IgG deposition along tubular basement membrane (TBM) was also detected in 31 (67.4%) patients. Among them, the IgG subclass distribution was similar to that of the deposition within the GBM: IgG1 6.5% (2/31), IgG2 45.2% (14/31), IgG3 100% (31/31) and IgG4 9.7% (3/31). We observed increased inflammatory cell infiltration into the interstitium in patients with increased anti-TBM IgG3 deposits (P=0.031).

CONCLUSIONS

Anti-GBM IgG3 predominantly deposits along GBM and TBM on renal biopsy specimens from patients with anti-GBM disease, which may be involved in the development of renal injury of the disease.

Authors+Show Affiliations

Department of Medicine, Peking University First Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23586976

Citation

Qu, Zhen, et al. "The Distribution of IgG Subclass Deposition On Renal Tissues From Patients With Anti-glomerular Basement Membrane Disease." BMC Immunology, vol. 14, 2013, p. 19.
Qu Z, Cui Z, Liu G, et al. The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease. BMC Immunol. 2013;14:19.
Qu, Z., Cui, Z., Liu, G., & Zhao, M. H. (2013). The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease. BMC Immunology, 14, 19. https://doi.org/10.1186/1471-2172-14-19
Qu Z, et al. The Distribution of IgG Subclass Deposition On Renal Tissues From Patients With Anti-glomerular Basement Membrane Disease. BMC Immunol. 2013 Apr 15;14:19. PubMed PMID: 23586976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease. AU - Qu,Zhen, AU - Cui,Zhao, AU - Liu,Gang, AU - Zhao,Ming-hui, Y1 - 2013/04/15/ PY - 2012/07/22/received PY - 2013/04/08/accepted PY - 2013/4/17/entrez PY - 2013/4/17/pubmed PY - 2013/11/15/medline SP - 19 EP - 19 JF - BMC immunology JO - BMC Immunol VL - 14 N2 - BACKGROUND: Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subclasses on renal tissue is still unclear. In the current study, we investigated the deposition of the four IgG subclasses using immunohistochemistry in the renal biopsy specimens from 46 patients with anti-GBM disease. RESULTS: All four IgG subclasses can be detected within the GBM. Anti-GBM IgG3 was detected in all patients (100%), with 39 (84.8%) patients presenting with weak segmental staining and 7 (15.2%) patients with strong linear deposition. Anti-GBM IgG2 was detected in 22 (47.8%) patients, with 20 (90.9%) patients having weak segmental deposition and 2 (9.1%) patients presenting strong linear staining. Anti-GBM IgG1 and IgG4 were detected in 9 (19.6%) and 7 (15.2%) patients, respectively. IgG deposition along tubular basement membrane (TBM) was also detected in 31 (67.4%) patients. Among them, the IgG subclass distribution was similar to that of the deposition within the GBM: IgG1 6.5% (2/31), IgG2 45.2% (14/31), IgG3 100% (31/31) and IgG4 9.7% (3/31). We observed increased inflammatory cell infiltration into the interstitium in patients with increased anti-TBM IgG3 deposits (P=0.031). CONCLUSIONS: Anti-GBM IgG3 predominantly deposits along GBM and TBM on renal biopsy specimens from patients with anti-GBM disease, which may be involved in the development of renal injury of the disease. SN - 1471-2172 UR - https://www.unboundmedicine.com/medline/citation/23586976/The_distribution_of_IgG_subclass_deposition_on_renal_tissues_from_patients_with_anti_glomerular_basement_membrane_disease_ L2 - https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-14-19 DB - PRIME DP - Unbound Medicine ER -