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Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children.
Nutr Rev 2013; 71(5):268-81NR

Abstract

This review examines the research on mechanisms by which artificial food colors (AFCs) and common foods may cause behavioral changes in children with and without attention-deficit/hyperactivity disorder (ADHD). Children with ADHD show excess inattention, impulsivity, and hyperactivity. Studies have shown that a subgroup of children (with or without ADHD) react adversely to challenges with AFCs. Many early studies found few children who reacted to challenges with 20-40 mg of AFCs. However, studies using at least 50 mg of AFCs showed a greater percentage of children who reacted to the challenge. Three types of potential mechanisms are explored: toxicological, antinutritional, and hypersensitivity. Suggestions for future studies in animals and/or children include dose studies as well as studies to determine the effects of AFCs on the immune system, the intestinal mucosa, and nutrient absorption. Given the potential negative behavioral effects of AFCs, it is important to determine why some children may be more sensitive to AFCs than others and to identify the tolerable upper limits of exposure for children in general and for children at high risk.

Authors+Show Affiliations

Department of Nutrition Science, Purdue University, West Lafayette, Indiana 47907, USA. stevens5@purdue.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23590704

Citation

Stevens, Laura J., et al. "Mechanisms of Behavioral, Atopic, and Other Reactions to Artificial Food Colors in Children." Nutrition Reviews, vol. 71, no. 5, 2013, pp. 268-81.
Stevens LJ, Kuczek T, Burgess JR, et al. Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children. Nutr Rev. 2013;71(5):268-81.
Stevens, L. J., Kuczek, T., Burgess, J. R., Stochelski, M. A., Arnold, L. E., & Galland, L. (2013). Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children. Nutrition Reviews, 71(5), pp. 268-81. doi:10.1111/nure.12023.
Stevens LJ, et al. Mechanisms of Behavioral, Atopic, and Other Reactions to Artificial Food Colors in Children. Nutr Rev. 2013;71(5):268-81. PubMed PMID: 23590704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children. AU - Stevens,Laura J, AU - Kuczek,Thomas, AU - Burgess,John R, AU - Stochelski,Mateusz A, AU - Arnold,L Eugene, AU - Galland,Leo, Y1 - 2013/03/13/ PY - 2013/4/18/entrez PY - 2013/4/18/pubmed PY - 2013/6/7/medline SP - 268 EP - 81 JF - Nutrition reviews JO - Nutr. Rev. VL - 71 IS - 5 N2 - This review examines the research on mechanisms by which artificial food colors (AFCs) and common foods may cause behavioral changes in children with and without attention-deficit/hyperactivity disorder (ADHD). Children with ADHD show excess inattention, impulsivity, and hyperactivity. Studies have shown that a subgroup of children (with or without ADHD) react adversely to challenges with AFCs. Many early studies found few children who reacted to challenges with 20-40 mg of AFCs. However, studies using at least 50 mg of AFCs showed a greater percentage of children who reacted to the challenge. Three types of potential mechanisms are explored: toxicological, antinutritional, and hypersensitivity. Suggestions for future studies in animals and/or children include dose studies as well as studies to determine the effects of AFCs on the immune system, the intestinal mucosa, and nutrient absorption. Given the potential negative behavioral effects of AFCs, it is important to determine why some children may be more sensitive to AFCs than others and to identify the tolerable upper limits of exposure for children in general and for children at high risk. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/23590704/Mechanisms_of_behavioral_atopic_and_other_reactions_to_artificial_food_colors_in_children_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/nure.12023 DB - PRIME DP - Unbound Medicine ER -