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Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA.
ACS Appl Mater Interfaces. 2013 May; 5(9):3847-54.AA

Abstract

Electrospun fibrous bio-nanocomposite scaffolds reinforced with cellulose nanocrystals (CNCs) were fabricated by using maleic anhydride (MAH) grafted poly(lactic acid) (PLA) as matrix with improved interfacial adhesion between the two components. Morphological, thermal, mechanical, and in vitro degradation properties as well as basic cytocompatibility using human adult adipose derived mesenchymal stem cells (hASCs) of MAH grafted PLA/CNC (i.e., MPLA/CNC) scaffolds were characterized. Morphological investigation indicated that the diameter and polydispersity of electrospun MPLA/CNC nanofibers were reduced with the increased CNC content. The addition of CNCs improved both the thermal stability and mechanical properties of MPLA/CNC composites. The MPLA/CNC scaffolds at the 5 wt % CNC loading level showed not only superior tensile strength (more than 10 MPa), but also improved stability during in vitro degradation compared with the MPLA and PLA/CNC counterparts. Moreover, the fibrous MPLA/CNC composite scaffolds were non-toxic to hASCs and capable of supporting cell proliferation. This study demonstrates that fibrous MPLA/CNC bio-nanocomposite scaffolds are biodegradable, cytocompatible, and possess useful mechanical properties for bone tissue engineering.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Zhou C
School of Renewable Natural Resources, Louisiana State University Agricultural Center, Baton Rouge, Louisiana 70803, United States.
Shi Q
No affiliation info available
Guo W
No affiliation info available
Terrell L
No affiliation info available
Qureshi AT
No affiliation info available
Hayes DJ
No affiliation info available
Wu Q
No affiliation info available

MeSH

Cell SurvivalCells, CulturedCelluloseElectrochemical TechniquesHumansLactic AcidMaleic AnhydridesMaterials TestingMesenchymal Stem CellsNanocompositesNanoparticlesNanotechnologyPolyestersPolymersTemperatureTissue EngineeringTissue Scaffolds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23590943

Citation

Zhou, Chengjun, et al. "Electrospun Bio-nanocomposite Scaffolds for Bone Tissue Engineering By Cellulose Nanocrystals Reinforcing Maleic Anhydride Grafted PLA." ACS Applied Materials & Interfaces, vol. 5, no. 9, 2013, pp. 3847-54.
Zhou C, Shi Q, Guo W, et al. Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA. ACS Appl Mater Interfaces. 2013;5(9):3847-54.
Zhou, C., Shi, Q., Guo, W., Terrell, L., Qureshi, A. T., Hayes, D. J., & Wu, Q. (2013). Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA. ACS Applied Materials & Interfaces, 5(9), 3847-54. https://doi.org/10.1021/am4005072
Zhou C, et al. Electrospun Bio-nanocomposite Scaffolds for Bone Tissue Engineering By Cellulose Nanocrystals Reinforcing Maleic Anhydride Grafted PLA. ACS Appl Mater Interfaces. 2013;5(9):3847-54. PubMed PMID: 23590943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA. AU - Zhou,Chengjun, AU - Shi,Qingfeng, AU - Guo,Weihong, AU - Terrell,Lekeith, AU - Qureshi,Ammar T, AU - Hayes,Daniel J, AU - Wu,Qinglin, Y1 - 2013/04/16/ PY - 2013/4/18/entrez PY - 2013/4/18/pubmed PY - 2013/10/22/medline SP - 3847 EP - 54 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 5 IS - 9 N2 - Electrospun fibrous bio-nanocomposite scaffolds reinforced with cellulose nanocrystals (CNCs) were fabricated by using maleic anhydride (MAH) grafted poly(lactic acid) (PLA) as matrix with improved interfacial adhesion between the two components. Morphological, thermal, mechanical, and in vitro degradation properties as well as basic cytocompatibility using human adult adipose derived mesenchymal stem cells (hASCs) of MAH grafted PLA/CNC (i.e., MPLA/CNC) scaffolds were characterized. Morphological investigation indicated that the diameter and polydispersity of electrospun MPLA/CNC nanofibers were reduced with the increased CNC content. The addition of CNCs improved both the thermal stability and mechanical properties of MPLA/CNC composites. The MPLA/CNC scaffolds at the 5 wt % CNC loading level showed not only superior tensile strength (more than 10 MPa), but also improved stability during in vitro degradation compared with the MPLA and PLA/CNC counterparts. Moreover, the fibrous MPLA/CNC composite scaffolds were non-toxic to hASCs and capable of supporting cell proliferation. This study demonstrates that fibrous MPLA/CNC bio-nanocomposite scaffolds are biodegradable, cytocompatible, and possess useful mechanical properties for bone tissue engineering. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/23590943/Electrospun_bio_nanocomposite_scaffolds_for_bone_tissue_engineering_by_cellulose_nanocrystals_reinforcing_maleic_anhydride_grafted_PLA_ L2 - https://doi.org/10.1021/am4005072 DB - PRIME DP - Unbound Medicine ER -