Tags

Type your tag names separated by a space and hit enter

Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease.
Clin Nutr. 2014 Feb; 33(1):90-7.CN

Abstract

BACKGROUND & AIMS

The metabolic syndrome (MetS) is a clustering of various metabolic abnormalities which is associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus. Due to its increasing prevalence, it has become an important public health concern. Altered fatty acid (FA) composition and desaturase activities have been associated with several metabolic diseases, including MetS. The aim of the present study was to evaluate the relationship of the plasma FA profile and desaturase activities with the MetS in a Mediterranean population at high risk of CVD.

METHODS

Baseline data from 427 participants aged 55-80 years who took part in the interventional PREDIMED study were obtained. Individual FA was determined in plasma and desaturase activities were estimated from product/precursor ratios. Odds ratios (OR) and partial correlation coefficients were used to examine these relations with MetS and its components, respectively.

RESULTS

We found higher levels of C14:0, C16:0, C16:1n-7, estimated Δ(9)- or stearoyl-CoA desaturase (SCD), and estimated Δ(6) desaturase (D6D), and lower levels of C18:2n-6 in people with MetS compared to those without it. After adjustment for several confounders, only higher quartiles of C14:0, C16:0, C16:1n-7, and D6D were found to be associated with an increasing prevalence of MetS, while higher quartiles of C18:2n-6 were inversely associated with MetS. High proportions of C14:0, C16:0, C16:1n-7, C20:3n-6, SCD, and D6D, and decreased proportions of C18:2n-6 and estimated Δ(5)-desaturase (D5D) were associated with adverse profiles of several metabolic risk factors. Women showed more unhealthy FA pattern and lipid profiles than men, but only among those with MetS.

CONCLUSION

A FA composition and estimated desaturase activities consisting in high levels of SFA, SCD and D6D, and low levels of PUFA and D5D are associated with increased MetS probability and are characteristic of people presenting MetS, especially women. These findings support those observed in non-Mediterranean populations in which an altered FA profile and estimated desaturase activities are associated with MetS.

Authors+Show Affiliations

CIBER Epidemiología y Salud Pública (CIBERESP), Spain.Department of Nutrition and Food Science, Reference Center in Food Technology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Nutrition and Food Science, Reference Center in Food Technology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.Department of Internal Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain.Cardiovascular Epidemiology Unit, Municipal Institute for Medical Research, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain.Cardiovascular Epidemiology Unit, Municipal Institute for Medical Research, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain.Human Nutrition Unit, Faculty of Medicine, IISPV, University Rovira i Virgili, Reus, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain.Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain; Department of Cardiology, University Hospital of Alava, Vitoria, Spain.Department of Nutrition and Food Science, Reference Center in Food Technology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), RETIC Alimentación Saludable RD 06/0045, Spain.CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Nutrition and Food Science, Reference Center in Food Technology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. Electronic address: mclopez@ub.edu.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23591154

Citation

Mayneris-Perxachs, Jordi, et al. "Plasma Fatty Acid Composition, Estimated Desaturase Activities, and Their Relation With the Metabolic Syndrome in a Population at High Risk of Cardiovascular Disease." Clinical Nutrition (Edinburgh, Scotland), vol. 33, no. 1, 2014, pp. 90-7.
Mayneris-Perxachs J, Guerendiain M, Castellote AI, et al. Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease. Clin Nutr. 2014;33(1):90-7.
Mayneris-Perxachs, J., Guerendiain, M., Castellote, A. I., Estruch, R., Covas, M. I., Fitó, M., Salas-Salvadó, J., Martínez-González, M. A., Aros, F., Lamuela-Raventós, R. M., & López-Sabater, M. C. (2014). Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease. Clinical Nutrition (Edinburgh, Scotland), 33(1), 90-7. https://doi.org/10.1016/j.clnu.2013.03.001
Mayneris-Perxachs J, et al. Plasma Fatty Acid Composition, Estimated Desaturase Activities, and Their Relation With the Metabolic Syndrome in a Population at High Risk of Cardiovascular Disease. Clin Nutr. 2014;33(1):90-7. PubMed PMID: 23591154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease. AU - Mayneris-Perxachs,Jordi, AU - Guerendiain,Marcela, AU - Castellote,Ana I, AU - Estruch,Ramón, AU - Covas,María Isabel, AU - Fitó,Montserrat, AU - Salas-Salvadó,Jordi, AU - Martínez-González,Miguel A, AU - Aros,Fernando, AU - Lamuela-Raventós,Rosa M, AU - López-Sabater,M Carmen, AU - ,, Y1 - 2013/03/28/ PY - 2013/01/18/received PY - 2013/02/08/revised PY - 2013/03/03/accepted PY - 2013/4/18/entrez PY - 2013/4/18/pubmed PY - 2014/9/12/medline KW - AA KW - ALA KW - CVD KW - D5D KW - D6D KW - DBP KW - DGLA KW - DHA KW - EPA KW - Estimated desaturase activities KW - FA KW - GLA KW - HDL-C KW - LA KW - LDL-C KW - MA KW - MGA KW - Mediterranean population KW - MetS KW - Metabolic risk factors KW - Metabolic syndrome KW - OA KW - PA KW - POA KW - Plasma fatty acid profile KW - SA KW - SBP KW - SCD KW - TC KW - WC KW - arachidonic acid KW - cardiovascular disease KW - diastolic blood pressure KW - dihommo-γ-linoleic acid KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - fatty acid KW - high-density lipoprotein cholesterol KW - linoleic acid KW - low-density lipoprotein cholesterol KW - margaric acid KW - metabolic syndrome KW - myristic acid KW - oleic acid KW - palmitic acid KW - palmitoleic acid KW - stearic acid KW - stearoyl coenzyme A desaturase KW - systolic blood pressure KW - total cholesterol KW - waist circumference KW - Δ(5) desaturase KW - Δ(6) desaturase KW - α-linolenic acid KW - γ-linolenic acid SP - 90 EP - 7 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 33 IS - 1 N2 - BACKGROUND & AIMS: The metabolic syndrome (MetS) is a clustering of various metabolic abnormalities which is associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus. Due to its increasing prevalence, it has become an important public health concern. Altered fatty acid (FA) composition and desaturase activities have been associated with several metabolic diseases, including MetS. The aim of the present study was to evaluate the relationship of the plasma FA profile and desaturase activities with the MetS in a Mediterranean population at high risk of CVD. METHODS: Baseline data from 427 participants aged 55-80 years who took part in the interventional PREDIMED study were obtained. Individual FA was determined in plasma and desaturase activities were estimated from product/precursor ratios. Odds ratios (OR) and partial correlation coefficients were used to examine these relations with MetS and its components, respectively. RESULTS: We found higher levels of C14:0, C16:0, C16:1n-7, estimated Δ(9)- or stearoyl-CoA desaturase (SCD), and estimated Δ(6) desaturase (D6D), and lower levels of C18:2n-6 in people with MetS compared to those without it. After adjustment for several confounders, only higher quartiles of C14:0, C16:0, C16:1n-7, and D6D were found to be associated with an increasing prevalence of MetS, while higher quartiles of C18:2n-6 were inversely associated with MetS. High proportions of C14:0, C16:0, C16:1n-7, C20:3n-6, SCD, and D6D, and decreased proportions of C18:2n-6 and estimated Δ(5)-desaturase (D5D) were associated with adverse profiles of several metabolic risk factors. Women showed more unhealthy FA pattern and lipid profiles than men, but only among those with MetS. CONCLUSION: A FA composition and estimated desaturase activities consisting in high levels of SFA, SCD and D6D, and low levels of PUFA and D5D are associated with increased MetS probability and are characteristic of people presenting MetS, especially women. These findings support those observed in non-Mediterranean populations in which an altered FA profile and estimated desaturase activities are associated with MetS. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/23591154/Plasma_fatty_acid_composition_estimated_desaturase_activities_and_their_relation_with_the_metabolic_syndrome_in_a_population_at_high_risk_of_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(13)00079-4 DB - PRIME DP - Unbound Medicine ER -