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Antibiotic resistance and carriage class 1 and 2 integrons in clinical isolates of Acinetobacter baumannii from Tehran, Iran.
Asian Pac J Trop Biomed. 2013 Feb; 3(2):140-5.AP

Abstract

OBJECTIVE

To investigate antibiotic resistance and carriage class 1 and 2 integrons in clinical isolates of Acinetobacter baumannii (A. baumannii) from Tehran, Iran.

METHODS

Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute. The presence of integrons was investigated by PCR using specific primers.

RESULTS

Among isolated A. baumannii strains, 82% were multidrug resistant, 27 samples (54%) were resistant to three or more than three antibiotics and 16 samples (32%) showed resistance to two antibiotics. Integrons were detected from 44 of 50 isolates (88%), with classes 1 and 2 being observed in 42% (21/50) and 82% (41/50) of isolates, respectively. Integron-positive A. baumannii isolates showed higher antibiotic resistance than integron-negative isolates and all showed a multidrug-resistant phenotype.

CONCLUSIONS

Our findings show that classes 1 and 2 integrons, and especially classes 2 integrons are widely disseminated among A. baumannii strains isolated from Tehran and these structures are playing a major role in the acquisition of multidrug resistance in these strains. So monitoring of drug resistance with investigating carriage class 1 and 2 integrons is very important to plan specific infection control measures due to multidrug resistance A. baumannii in Iran hospitals.

Authors+Show Affiliations

Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23593593

Citation

Mirnejad, Reza, et al. "Antibiotic Resistance and Carriage Class 1 and 2 Integrons in Clinical Isolates of Acinetobacter Baumannii From Tehran, Iran." Asian Pacific Journal of Tropical Biomedicine, vol. 3, no. 2, 2013, pp. 140-5.
Mirnejad R, Mostofi S, Masjedian F. Antibiotic resistance and carriage class 1 and 2 integrons in clinical isolates of Acinetobacter baumannii from Tehran, Iran. Asian Pac J Trop Biomed. 2013;3(2):140-5.
Mirnejad, R., Mostofi, S., & Masjedian, F. (2013). Antibiotic resistance and carriage class 1 and 2 integrons in clinical isolates of Acinetobacter baumannii from Tehran, Iran. Asian Pacific Journal of Tropical Biomedicine, 3(2), 140-5. https://doi.org/10.1016/S2221-1691(13)60038-6
Mirnejad R, Mostofi S, Masjedian F. Antibiotic Resistance and Carriage Class 1 and 2 Integrons in Clinical Isolates of Acinetobacter Baumannii From Tehran, Iran. Asian Pac J Trop Biomed. 2013;3(2):140-5. PubMed PMID: 23593593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic resistance and carriage class 1 and 2 integrons in clinical isolates of Acinetobacter baumannii from Tehran, Iran. AU - Mirnejad,Reza, AU - Mostofi,Sepideh, AU - Masjedian,Faramaz, PY - 2012/11/06/received PY - 2012/12/01/accepted PY - 2013/4/18/entrez PY - 2013/4/18/pubmed PY - 2013/4/18/medline KW - Acinetobacter baumannii KW - Integron KW - Multidrug resistance SP - 140 EP - 5 JF - Asian Pacific journal of tropical biomedicine JO - Asian Pac J Trop Biomed VL - 3 IS - 2 N2 - OBJECTIVE: To investigate antibiotic resistance and carriage class 1 and 2 integrons in clinical isolates of Acinetobacter baumannii (A. baumannii) from Tehran, Iran. METHODS: Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute. The presence of integrons was investigated by PCR using specific primers. RESULTS: Among isolated A. baumannii strains, 82% were multidrug resistant, 27 samples (54%) were resistant to three or more than three antibiotics and 16 samples (32%) showed resistance to two antibiotics. Integrons were detected from 44 of 50 isolates (88%), with classes 1 and 2 being observed in 42% (21/50) and 82% (41/50) of isolates, respectively. Integron-positive A. baumannii isolates showed higher antibiotic resistance than integron-negative isolates and all showed a multidrug-resistant phenotype. CONCLUSIONS: Our findings show that classes 1 and 2 integrons, and especially classes 2 integrons are widely disseminated among A. baumannii strains isolated from Tehran and these structures are playing a major role in the acquisition of multidrug resistance in these strains. So monitoring of drug resistance with investigating carriage class 1 and 2 integrons is very important to plan specific infection control measures due to multidrug resistance A. baumannii in Iran hospitals. SN - 2221-1691 UR - https://www.unboundmedicine.com/medline/citation/23593593/Antibiotic_resistance_and_carriage_class_1_and_2_integrons_in_clinical_isolates_of_Acinetobacter_baumannii_from_Tehran_Iran_ L2 - https://linkinghub.elsevier.com/retrieve/pii/apjtb-03-02-140 DB - PRIME DP - Unbound Medicine ER -