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[Changes in arterial thromboxane B2 and 6-keto-prostaglandin-F1 alpha levels in cirrhotic and non-cirrhotic patients after hepatectomy].
Nihon Geka Gakkai Zasshi. 1990 Mar; 91(3):386-92.NG

Abstract

Following hepatectomy, arterial concentrations of thromboxane B2(TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), which are stable metabolites of thromboxane A2(TXA2) and prostaglandin I2(PGI2), were measured by radioimmunoassay in 17 cirrhotic and 9 non-cirrhotic patients to assess the role of TXB2 and PGI2 in patients with liver dysfunction during hepatectomy. In both cirrhotic and non-cirrhotic patients, arterial TXB2 and 6-keto-PGF1 alpha levels significantly increased during hepatectomy and decreased to preoperative levels at the 1st postoperative day (1-POD). The TXB2/6-keto-PGF1 alpha ratio significantly decreased during hepatectomy and at 1-POD. There were no significant differences in changes of TXB2 and PGI2 levels between cirrhotic and non-cirrhotic patients. In cirrhotic patients with poor hepatic reserve, whose ICG K values were less than 0.08, arterial 6-keto-PGF1 alpha levels were significantly higher and the ratio were significantly lower than in cirrhotic patients with good hepatic reserve and non-cirrhotic patients before and after operation. Based on these results, it is concluded that the TXA2/PGI2 ratio becomes low after hepatectomy and the ratio is lower in cirrhotic patients with poor hepatic reserve.

Authors+Show Affiliations

Department of Surgery II, School of Medicine, Kanazawa University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

2359395

Citation

Shimizu, K, et al. "[Changes in Arterial Thromboxane B2 and 6-keto-prostaglandin-F1 Alpha Levels in Cirrhotic and Non-cirrhotic Patients After Hepatectomy]." Nihon Geka Gakkai Zasshi, vol. 91, no. 3, 1990, pp. 386-92.
Shimizu K, Izumi R, Iyobe T, et al. [Changes in arterial thromboxane B2 and 6-keto-prostaglandin-F1 alpha levels in cirrhotic and non-cirrhotic patients after hepatectomy]. Nihon Geka Gakkai Zasshi. 1990;91(3):386-92.
Shimizu, K., Izumi, R., Iyobe, T., Mori, K., Tani, T., Yabushita, K., & Miyazaki, I. (1990). [Changes in arterial thromboxane B2 and 6-keto-prostaglandin-F1 alpha levels in cirrhotic and non-cirrhotic patients after hepatectomy]. Nihon Geka Gakkai Zasshi, 91(3), 386-92.
Shimizu K, et al. [Changes in Arterial Thromboxane B2 and 6-keto-prostaglandin-F1 Alpha Levels in Cirrhotic and Non-cirrhotic Patients After Hepatectomy]. Nihon Geka Gakkai Zasshi. 1990;91(3):386-92. PubMed PMID: 2359395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes in arterial thromboxane B2 and 6-keto-prostaglandin-F1 alpha levels in cirrhotic and non-cirrhotic patients after hepatectomy]. AU - Shimizu,K, AU - Izumi,R, AU - Iyobe,T, AU - Mori,K, AU - Tani,T, AU - Yabushita,K, AU - Miyazaki,I, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 386 EP - 92 JF - Nihon Geka Gakkai zasshi JO - Nihon Geka Gakkai Zasshi VL - 91 IS - 3 N2 - Following hepatectomy, arterial concentrations of thromboxane B2(TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), which are stable metabolites of thromboxane A2(TXA2) and prostaglandin I2(PGI2), were measured by radioimmunoassay in 17 cirrhotic and 9 non-cirrhotic patients to assess the role of TXB2 and PGI2 in patients with liver dysfunction during hepatectomy. In both cirrhotic and non-cirrhotic patients, arterial TXB2 and 6-keto-PGF1 alpha levels significantly increased during hepatectomy and decreased to preoperative levels at the 1st postoperative day (1-POD). The TXB2/6-keto-PGF1 alpha ratio significantly decreased during hepatectomy and at 1-POD. There were no significant differences in changes of TXB2 and PGI2 levels between cirrhotic and non-cirrhotic patients. In cirrhotic patients with poor hepatic reserve, whose ICG K values were less than 0.08, arterial 6-keto-PGF1 alpha levels were significantly higher and the ratio were significantly lower than in cirrhotic patients with good hepatic reserve and non-cirrhotic patients before and after operation. Based on these results, it is concluded that the TXA2/PGI2 ratio becomes low after hepatectomy and the ratio is lower in cirrhotic patients with poor hepatic reserve. SN - 0301-4894 UR - https://www.unboundmedicine.com/medline/citation/2359395/[Changes_in_arterial_thromboxane_B2_and_6_keto_prostaglandin_F1_alpha_levels_in_cirrhotic_and_non_cirrhotic_patients_after_hepatectomy]_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -