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Spray-dried O-carboxymethyl chitosan as potential hydrophilic matrix tablet for sustained release of drug.
Drug Dev Ind Pharm. 2014 Apr; 40(4):503-10.DD

Abstract

OBJECTIVE

The aim of the present investigation was to evaluate the use of spray-dried O-carboxymethyl chitosan (OCMCS) as potential hydrophilic matrix excipient for sustained release of drug.

METHODS

The polymer was synthesized from chitosan, then spray-dried and characterized. Tablets with different OCMCS concentrations (80, 50, 30, 5 and 2% w/w), containing diltiazem (DTZ) as model drug, were prepared for direct compression (DC) and after the wet granulation method (WG).

RESULTS

The spray-dried OCMCS powder was spherical, with a smooth surface and an average size of 2.2 µm. The tablets prepared for WG disintegrated in time less than 30 min. The tablets obtained for DC presented high retention of the drug, with zero order or Higuchi release kinetic. There was a direct relationship between the OCMCS concentration and the release ratio, swelling degree and water uptake behavior. DC tablets containing 80% OCMCS presented behavior as an effective swelling-control system. The DC tablets with 5% OCMCS showed a similar release profile at formulations with 30% HPMC.

CONCLUSION

Spray-dried OCMCS showed great potential as hydrophilic matrices for drug-sustained release.

Authors+Show Affiliations

Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI) , Itajaí, SC , Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23594298

Citation

Bresolin, José R., et al. "Spray-dried O-carboxymethyl Chitosan as Potential Hydrophilic Matrix Tablet for Sustained Release of Drug." Drug Development and Industrial Pharmacy, vol. 40, no. 4, 2014, pp. 503-10.
Bresolin JR, Largura MC, Dalri CC, et al. Spray-dried O-carboxymethyl chitosan as potential hydrophilic matrix tablet for sustained release of drug. Drug Dev Ind Pharm. 2014;40(4):503-10.
Bresolin, J. R., Largura, M. C., Dalri, C. C., Hoffer, G., Rodrigues, C. A., & Lucinda-Silva, R. M. (2014). Spray-dried O-carboxymethyl chitosan as potential hydrophilic matrix tablet for sustained release of drug. Drug Development and Industrial Pharmacy, 40(4), 503-10. https://doi.org/10.3109/03639045.2013.771644
Bresolin JR, et al. Spray-dried O-carboxymethyl Chitosan as Potential Hydrophilic Matrix Tablet for Sustained Release of Drug. Drug Dev Ind Pharm. 2014;40(4):503-10. PubMed PMID: 23594298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spray-dried O-carboxymethyl chitosan as potential hydrophilic matrix tablet for sustained release of drug. AU - Bresolin,José R, AU - Largura,Maria-Claudia T, AU - Dalri,Camila C, AU - Hoffer,Geórgia, AU - Rodrigues,Clóvis A, AU - Lucinda-Silva,Ruth M, Y1 - 2013/04/17/ PY - 2013/4/19/entrez PY - 2013/4/19/pubmed PY - 2014/11/5/medline SP - 503 EP - 10 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 40 IS - 4 N2 - OBJECTIVE: The aim of the present investigation was to evaluate the use of spray-dried O-carboxymethyl chitosan (OCMCS) as potential hydrophilic matrix excipient for sustained release of drug. METHODS: The polymer was synthesized from chitosan, then spray-dried and characterized. Tablets with different OCMCS concentrations (80, 50, 30, 5 and 2% w/w), containing diltiazem (DTZ) as model drug, were prepared for direct compression (DC) and after the wet granulation method (WG). RESULTS: The spray-dried OCMCS powder was spherical, with a smooth surface and an average size of 2.2 µm. The tablets prepared for WG disintegrated in time less than 30 min. The tablets obtained for DC presented high retention of the drug, with zero order or Higuchi release kinetic. There was a direct relationship between the OCMCS concentration and the release ratio, swelling degree and water uptake behavior. DC tablets containing 80% OCMCS presented behavior as an effective swelling-control system. The DC tablets with 5% OCMCS showed a similar release profile at formulations with 30% HPMC. CONCLUSION: Spray-dried OCMCS showed great potential as hydrophilic matrices for drug-sustained release. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/23594298/Spray_dried_O_carboxymethyl_chitosan_as_potential_hydrophilic_matrix_tablet_for_sustained_release_of_drug_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2013.771644 DB - PRIME DP - Unbound Medicine ER -