Tags

Type your tag names separated by a space and hit enter

Predicting Sjögren's syndrome in patients with recent-onset SLE.
Rheumatology (Oxford). 2013 Aug; 52(8):1438-42.R

Abstract

OBJECTIVE

To determine the prevalence of SS in a cohort of recent-onset SLE patients and evaluate the clinical and immunological variables that may identify SLE patients prone to develop SS.

METHODS

A total of 103 patients participating in a prospective cohort of recent-onset SLE were assessed for fulfilment of the American European Consensus Group criteria for SS using a three-phase approach: screening (European questionnaire, Schirmer-I test and wafer test), confirmation (fluorescein staining test, non-stimulated whole-salivary flow and anti-Ro/La antibodies) and lip biopsy. Anti-Ro/SSA and anti-La/SSB antibodies and RF were measured at entry into the cohort and at SS assessment.

RESULTS

Ninety-three females and 10 males were included. Mean age at lupus diagnosis was 25.9 ± 8.9 years, and lupus duration at SS assessment was 30.9 ± 9.1 years. SS was diagnosed in 19 (18.5%) patients, all female, and the patients were older at SLE diagnosis than patients without SS (30.8 ± 9.3 vs 24 ± 8.8 years, P = 0.004). Anti-Ro/SSA antibody was more common in SLE-SS patients (84% vs 55%, P = 0.02, LR + 1.53, 95% CI 1.14, 2.04). In the multivariate analysis, age ≥25 years and anti-Ro/SSA antibodies at SLE diagnosis were identified as predictors of SLE-SS, while the absence of anti-Ro/SSA, anti-La/SSB and RF seems to be protective (LR- 0.14, 95% CI 0.02, 0.95).

CONCLUSION

The overlap of SLE and SS occurs in almost one-fifth of SLE patients and presents early during its evolution. SLE onset at age ≥25 years plus the presence of anti-Ro/SSA antibody at diagnosis are useful predictors, while the absence of anti-Ro/SSA, anti-La/SSB and RF identifies patients at lowest risk.

Authors+Show Affiliations

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23594470

Citation

Hernández-Molina, Gabriela, et al. "Predicting Sjögren's Syndrome in Patients With Recent-onset SLE." Rheumatology (Oxford, England), vol. 52, no. 8, 2013, pp. 1438-42.
Hernández-Molina G, Zamora-Legoff T, Romero-Díaz J, et al. Predicting Sjögren's syndrome in patients with recent-onset SLE. Rheumatology (Oxford). 2013;52(8):1438-42.
Hernández-Molina, G., Zamora-Legoff, T., Romero-Díaz, J., Nuñez-Alvarez, C. A., Cárdenas-Velázquez, F., Hernández-Hernández, C., Calderillo, M. L., Marroquín, M., Recillas-Gispert, C., Ávila-Casado, C., & Sánchez-Guerrero, J. (2013). Predicting Sjögren's syndrome in patients with recent-onset SLE. Rheumatology (Oxford, England), 52(8), 1438-42. https://doi.org/10.1093/rheumatology/ket141
Hernández-Molina G, et al. Predicting Sjögren's Syndrome in Patients With Recent-onset SLE. Rheumatology (Oxford). 2013;52(8):1438-42. PubMed PMID: 23594470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting Sjögren's syndrome in patients with recent-onset SLE. AU - Hernández-Molina,Gabriela, AU - Zamora-Legoff,Tatiana, AU - Romero-Díaz,Juanita, AU - Nuñez-Alvarez,Carlos A, AU - Cárdenas-Velázquez,Francisco, AU - Hernández-Hernández,Carlos, AU - Calderillo,Maria Luisa, AU - Marroquín,Martha, AU - Recillas-Gispert,Claudia, AU - Ávila-Casado,Carmen, AU - Sánchez-Guerrero,Jorge, Y1 - 2013/04/16/ PY - 2013/4/19/entrez PY - 2013/4/19/pubmed PY - 2013/9/26/medline KW - SLE KW - Sjögren’s syndrome KW - anti-Ro/SSA and anti-La/SSB antibodies SP - 1438 EP - 42 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 52 IS - 8 N2 - OBJECTIVE: To determine the prevalence of SS in a cohort of recent-onset SLE patients and evaluate the clinical and immunological variables that may identify SLE patients prone to develop SS. METHODS: A total of 103 patients participating in a prospective cohort of recent-onset SLE were assessed for fulfilment of the American European Consensus Group criteria for SS using a three-phase approach: screening (European questionnaire, Schirmer-I test and wafer test), confirmation (fluorescein staining test, non-stimulated whole-salivary flow and anti-Ro/La antibodies) and lip biopsy. Anti-Ro/SSA and anti-La/SSB antibodies and RF were measured at entry into the cohort and at SS assessment. RESULTS: Ninety-three females and 10 males were included. Mean age at lupus diagnosis was 25.9 ± 8.9 years, and lupus duration at SS assessment was 30.9 ± 9.1 years. SS was diagnosed in 19 (18.5%) patients, all female, and the patients were older at SLE diagnosis than patients without SS (30.8 ± 9.3 vs 24 ± 8.8 years, P = 0.004). Anti-Ro/SSA antibody was more common in SLE-SS patients (84% vs 55%, P = 0.02, LR + 1.53, 95% CI 1.14, 2.04). In the multivariate analysis, age ≥25 years and anti-Ro/SSA antibodies at SLE diagnosis were identified as predictors of SLE-SS, while the absence of anti-Ro/SSA, anti-La/SSB and RF seems to be protective (LR- 0.14, 95% CI 0.02, 0.95). CONCLUSION: The overlap of SLE and SS occurs in almost one-fifth of SLE patients and presents early during its evolution. SLE onset at age ≥25 years plus the presence of anti-Ro/SSA antibody at diagnosis are useful predictors, while the absence of anti-Ro/SSA, anti-La/SSB and RF identifies patients at lowest risk. SN - 1462-0332 UR - https://www.unboundmedicine.com/medline/citation/23594470/Predicting_Sjögren's_syndrome_in_patients_with_recent_onset_SLE_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/ket141 DB - PRIME DP - Unbound Medicine ER -