Tags

Type your tag names separated by a space and hit enter

Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study.
Cornea 2013; 32(7):987-91C

Abstract

PURPOSE

To assess the herpes simplex virus-specific tear secretory IgA (sIgA) and its correlation with specific serum antibodies and to evaluate the possible value of specific tear sIgA for prediction of herpes simplex keratitis (HSK) recurrence.

METHODS

Tear sIgA and paired serum IgG/IgM/IgA from 41 stromal HSK patients and 15 controls were analyzed by enzyme-linked immunosorbent assay. Subsequent follow-up for monitoring recurrence was performed from the time of first cure on all patients for 4 months to 1 year.

RESULTS

Serum IgG was positive in all participants. The concentration of serum IgA increased with the levels of tear sIgA (P = 0.017). The tear sIgA-positive rate was 36.59% in stromal keratitis, whereas none of the controls were found as sIgA positive. Positivity of sIgA was the only potential factor for predicting the risk of herpes keratitis recurrence (hazard ratio = 9.04; 95% confidence interval, 1.06-77.44; P = 0.045), with a sensitivity of 83.3% and a specificity of 71.4% (P = 0.034; 95% confidence interval, 0.58-0.97). Tear sIgA-positive patients had significantly shorter relapse-free survival compared with tear sIgA-negative patients (P = 0.015).

CONCLUSIONS

This is the first preliminary study suggesting that the levels of tear sIgA could be a potential prognostic parameter for the recurrence of HSK.

Authors+Show Affiliations

Department of Ophthalmology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23594767

Citation

Huang, Fei-fei, et al. "Tear HSV-specific Secretory IgA as a Potential Indicator for Recurrent Stromal Herpes Simplex Keratitis: a Preliminary Study." Cornea, vol. 32, no. 7, 2013, pp. 987-91.
Huang FF, Wang ZJ, Zhang CR. Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study. Cornea. 2013;32(7):987-91.
Huang, F. F., Wang, Z. J., & Zhang, C. R. (2013). Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study. Cornea, 32(7), pp. 987-91. doi:10.1097/ICO.0b013e31828a8b96.
Huang FF, Wang ZJ, Zhang CR. Tear HSV-specific Secretory IgA as a Potential Indicator for Recurrent Stromal Herpes Simplex Keratitis: a Preliminary Study. Cornea. 2013;32(7):987-91. PubMed PMID: 23594767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study. AU - Huang,Fei-fei, AU - Wang,Zhu-jian, AU - Zhang,Chao-ran, PY - 2013/4/19/entrez PY - 2013/4/19/pubmed PY - 2014/1/9/medline SP - 987 EP - 91 JF - Cornea JO - Cornea VL - 32 IS - 7 N2 - PURPOSE: To assess the herpes simplex virus-specific tear secretory IgA (sIgA) and its correlation with specific serum antibodies and to evaluate the possible value of specific tear sIgA for prediction of herpes simplex keratitis (HSK) recurrence. METHODS: Tear sIgA and paired serum IgG/IgM/IgA from 41 stromal HSK patients and 15 controls were analyzed by enzyme-linked immunosorbent assay. Subsequent follow-up for monitoring recurrence was performed from the time of first cure on all patients for 4 months to 1 year. RESULTS: Serum IgG was positive in all participants. The concentration of serum IgA increased with the levels of tear sIgA (P = 0.017). The tear sIgA-positive rate was 36.59% in stromal keratitis, whereas none of the controls were found as sIgA positive. Positivity of sIgA was the only potential factor for predicting the risk of herpes keratitis recurrence (hazard ratio = 9.04; 95% confidence interval, 1.06-77.44; P = 0.045), with a sensitivity of 83.3% and a specificity of 71.4% (P = 0.034; 95% confidence interval, 0.58-0.97). Tear sIgA-positive patients had significantly shorter relapse-free survival compared with tear sIgA-negative patients (P = 0.015). CONCLUSIONS: This is the first preliminary study suggesting that the levels of tear sIgA could be a potential prognostic parameter for the recurrence of HSK. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/23594767/Tear_HSV_specific_secretory_IgA_as_a_potential_indicator_for_recurrent_stromal_herpes_simplex_keratitis:_a_preliminary_study_ L2 - http://Insights.ovid.com/pubmed?pmid=23594767 DB - PRIME DP - Unbound Medicine ER -