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Hepatitis E: a puzzling double-faced disease.
Ann Ig. 2013 May-Jun; 25(3):169-80.AI

Abstract

Viral hepatitis type E is highly endemic in many developing countries, where large water-borne epidemics caused by viral genotype 1 and - to a lesser degree - by genotype 2 cyclically occur, resulting in high morbidity and mortality, especially among pregnant women. In developed countries, the disease is usually diagnosed in travelers coming back from endemic countries, but an increasing number of sporadic locally acquired hepatitis cases caused by genotype 3 and 4 have recently been reported. The wide-spread distribution of HEV3 and HEV4 in domestic pigs, wild boars, deer, as well as in other mammals, suggests that infections caused by these genotypes may have a zoonotic source. HEV3 infection can evolve to chronic infection in immunosuppressed patients; in addition, it may be associated with neurological disorders and extrahepatic manifestations. Two recently developed recombinant vaccines have proved to be safe and effective. One of such vaccines has recently been licensed for use in China.

Authors+Show Affiliations

Department of Biomedical Sciences for Health, University of Milan, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23598800

Citation

Romanò, L, et al. "Hepatitis E: a Puzzling Double-faced Disease." Annali Di Igiene : Medicina Preventiva E Di Comunita, vol. 25, no. 3, 2013, pp. 169-80.
Romanò L, Paladini S, Zanetti AR. Hepatitis E: a puzzling double-faced disease. Ann Ig. 2013;25(3):169-80.
Romanò, L., Paladini, S., & Zanetti, A. R. (2013). Hepatitis E: a puzzling double-faced disease. Annali Di Igiene : Medicina Preventiva E Di Comunita, 25(3), 169-80. https://doi.org/10.7416/ai.2013.1919
Romanò L, Paladini S, Zanetti AR. Hepatitis E: a Puzzling Double-faced Disease. Ann Ig. 2013 May-Jun;25(3):169-80. PubMed PMID: 23598800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E: a puzzling double-faced disease. AU - Romanò,L, AU - Paladini,S, AU - Zanetti,A R, PY - 2013/4/20/entrez PY - 2013/4/20/pubmed PY - 2013/8/10/medline SP - 169 EP - 80 JF - Annali di igiene : medicina preventiva e di comunita JO - Ann Ig VL - 25 IS - 3 N2 - Viral hepatitis type E is highly endemic in many developing countries, where large water-borne epidemics caused by viral genotype 1 and - to a lesser degree - by genotype 2 cyclically occur, resulting in high morbidity and mortality, especially among pregnant women. In developed countries, the disease is usually diagnosed in travelers coming back from endemic countries, but an increasing number of sporadic locally acquired hepatitis cases caused by genotype 3 and 4 have recently been reported. The wide-spread distribution of HEV3 and HEV4 in domestic pigs, wild boars, deer, as well as in other mammals, suggests that infections caused by these genotypes may have a zoonotic source. HEV3 infection can evolve to chronic infection in immunosuppressed patients; in addition, it may be associated with neurological disorders and extrahepatic manifestations. Two recently developed recombinant vaccines have proved to be safe and effective. One of such vaccines has recently been licensed for use in China. SN - 1120-9135 UR - https://www.unboundmedicine.com/medline/citation/23598800/Hepatitis_E:_a_puzzling_double_faced_disease_ L2 - http://www.seu-roma.it/riviste/annali_igiene/apps/autos.php?id=851 DB - PRIME DP - Unbound Medicine ER -